Which came first, the moth or the cactus?
...seeds. Historic theory predicts extreme ecological instability for this relationship; as moth populations increas...s to predictions of unbounded population growth or instability and eventual doom due to one species overexploiting another. These predictions clearly don't square ...What we can learn from the biggest extinction in the history of Earth
...ic extinction and the following 4 million years of instability in the global carbon cycle. In the July issue of the Geological Society of America Bulletin, Payne presented evidence that a massive, rapid release of carbon may have triggered this extinction. "People point to the fossil record as a place where we...Lost forest yields several new species
... to scientists since 1960 as a result of continued instability in the area. If we can find six new species in such a short period it makes you wonder what else is out there, said WCS researcher Dr. Andrew Plumptre, director of the societys Albertine Rift Program. The forest survey was conducted between Jan...NIEHS researchers identify enzyme critical in DNA replication
...step closer to understanding the origins of genome instability that underlie certain environmental diseases in humans, said NIEHS Director David A. Schwartz, M.D. NIEHS is part of the National Institutes of Health. The research was conducted by Zachary Pursell, Ph.D. and Thomas A. Kunkel, Ph.D., at NIEHS in ...Support for chromosomal theory of cancer found in cancers' development of drug resistance
...ore drugs it becomes resistant to. "The inherent instability of aneuploidy thus explains the enormous adaptability of cancers against cytotoxic drugs and dims hopes for gene-specific therapies," Duesberg, Li and their co-authors wrote. While this is bad news for cancer patients, Duesberg pointed out that the...Mathematics reveals genetic pattern of tumor growth
...n leads to tumor growth. The occurrence of genetic instability is often debated by cancer scientists, some of whom believe that cancer feeds on this instability and others who believe it is a side-effect of the cancer itself. To determine the pattern of genet...UD awarded $11M for osteoarthritis research and unique mentoring program for women scientists
...iceps strength, knee stiffness, proprioception and instability contribute to osteoarthritis of the knee. The study will help researchers understand the strategies that can be used to improve knee function without further joint damage and aid in developing screening tools to identify patients who will benefit fro...Sensitivity to diverse range of chemotherapeutic drugs linked to common pathway
...efficacy in tumors with high levels of chromosomal instability characterized by chromosomal numerical heterogeneity and provide a rational basis for identification of patients likely to benefit from these drugs, explains Dr. Downward....Virus widely used in gene therapy research yields important clues to genomic instability
...many human cancers. Although the source of genomic instability has been established for many inherited human canc...he ability to study the potential cause of genomic instability in sporadic cancers using a recombinant adeno-associated virus, the same virus that many researchers...New mouse model closely mimics human cancers
...ple myeloma. The comparisons showed that genetic instability in the mouse cancer cells caused DNA alterations t...y characteristics of human tumors, such as genomic instability -- pieces of chromosomes breaking apart and reattaching, which result in widespread abnormalities li...Role of autophagy in tumorigenesis
... survival during starvation, the concurrent genome instability could accelerate tumor progression. Thus, the normal function of autophagy sustains, but also protects cells by limiting genome damage during starvation. "Understanding mechanisms by which tumor cells respond to metabolic stress is key to designing ...Burroughs Wellcome Fund awards $14M to support physician-scientists
...cular basis and therapeutic implications of genome instability during brain tumor progression Arlene Dent, M.D., Ph.D. Case Western Reserve University Acquisition of immunity to blood stage Falciparum malaria in infants Mahalia Sabrina Desruisseaux, M.D. Albert Einstein College of Medicine of Yeshiva Uni...Baumann Lab defines proteins that distinguish chromosome ends from DNA double-strand breaks
...obb Krumlauf, Ph.D., Scientific Director. "Genomic instability and gross chromosomal rearrangements are a hallmar... of chromosome end protection can initiate genomic instability through bridge-breakage-fusion cycles. It is, therefore, very important to understand the mechanism ...Unstable leukemia stem cells may predispose patients to drug resistance
... in Boston, discuss the possible causes of genetic instability in the BCR-ABL gene and future approaches to developing successful therapies for chronic myeloid leukemia. A future challenge will be to devise approaches that overcome drug resistance within these [chronic myeloid leukemia stem] cells without select...Alternative-fuels pioneer receives first-ever $100,000 Lemelson-MIT Award for Sustainability
...in the wake of Hurricane Katrina and the political instability in the Middle East. In 2006, with Series A funding from Khosla Ventures and other financiers, Lynd co-founded a start-up company called Mascoma Corporation to advance technologies such as consolidated bioprocessing and make fuel production from cellu...CSHL research ties harmless viruses to cancer
... that have been considered harmless to chromosomal instability (CIN) and cancer. "If the model that we propose is correct, protecting the body against viruses, or preventing the cell fusion that they cause may decrease the frequency of cancers and prevent their progression," said CSHLs lead investigator Yuri La...Protecting US crops from terrorist attack to be discussed at 2007 AAAS Annual Meeting
...rices, lost markets and trade embargoes, financial instability of rural communities, and loss of public confidence in the food supply," she said. Fletcher's presentation will focus on the need for both prevention, including border inspections and crop surveillance, and preparedness, including tools for rapid ...Shortening chromosomes cause for earlier cancer onset in families with rare syndrome
...neration of disease carriers, leading to a genetic instability that primes them for progressively earlier cancers...alkin and his colleagues link telomeres to genetic instability and cancer in the context of Li-Fraumeni syndrome, other researchers have studied whether it might b...FISH-ing for links between cancer and aging
... Werner Syndrome cells is a major cause of genomic instability and could explain the high incidence of cancer seen in this disease." Translating these findings into a treatment for Werner Syndrome will be extremely difficult. However, Karlseder feels optimistic about what these investigations show. "We study t......es in the global regulation of microtubule dynamic instability are not as clear. Using VIP, these researchers show that microtubules are stable during interphase because the destabilizer is inhibited by the other molecul es. During mitosis, however, the destabilizer is released, triggering the alteration of micr...