Cease and desist -- genome stability and epithelial carcinogenesis
...ion. Mutations in separase resulted in chromosomal instability and increased epithelial tumor load after exposure to carcinogens. Lead author, Dr. Jennifer Shepard, emphasizes that "Our work is the first evidence that separase acts as a tumor suppressor gene and further supports a role for genes that regulate ge...Regulating the nuclear architecture of the cell
...chromatin could be one cause of the rampant genome instability observed in cancer. Beyond these specific pathways, we're interested in the larger question of how such pathways affect the organization of the chromosomes in the cell nucleus."...Mutant mouse provides insights into breast cancer
...d increase in a hallmark for cancer called genomic instability -- a blanket term for an elevation in the number o...ancers, by the time you look at them, have genomic instability in some form or another," said John Schimenti, a genetics professor in Cornell's Departments of Biom...The Milky Way shaped life on Earth
...rashed in a succession of booms and busts, with an instability not seen before or since. According to new results published by Dr. Henrik Svensmark of the Danish National Space Center in the journal Astronomische Nachrichten, the variability in the productivity of life is closely linked to the cosmic rays, the a...Orange juice beverage fortified with plant sterols lowers indicators of heart disease risk
... may actively contribute to the progression and/or instability of atherosclerotic plaques. The American Heart Association and Centers for Disease Control and Prevention now recommend that C-reactive protein levels be used to further evaluate cardiovascular disease risk. According to Jialal, the simultaneous re...... pathway. But at the same time there's evidence of instability in other areas. According to Dr. Evsikov, "There's tantalizing evidence for rapid change in a few critical mammalian genes specifically expressed in eggs. These fast-paced changes may pinpoint the molecular mechanisms for reproductive isolation, a ...Viral oncoprotein inactivation of p53
...pressor function of p53, which can lead to genomic instability and tumor formation"....Cigarette smoke blocks cell repair mechanism, University of Florida study shows
...genome and causes genomic instability, and genomic instability can bring about several cellular dysfunctions, and...ffected. Only a single cell which may have genomic instability due to compromised DNA repair capacity of the cell can be sufficient for a tumor to develop. That ha...'Signature' of chromosome instability predicts cancer outcomes
...port that a genetic profile indicating chromosomal instability -- an increased tendency to develop chromosomal ab...urnal Nature Genetics on August 20. "Chromosomal instability is one of the key mechanisms that keeps malignant cell proliferation going," says Zoltan Szallasi, M...University of Washington researchers discover novel genomic disorders
...hat the genome contains hotspots that are prone to instability and thus play a key role in the occurrence of genomic disorders. These hotspots are flanked on each side by large, repetitive regions of DNA, termed "segmental duplications". It is because of the repetitive nature of these regions that, during replic...Contagious cancer in dogs confirmed; origins traced to wolves centuries ago
... it might also raise important new ideas about the instability of cancer," Weiss said. It has become dogma tha...s cancer develops, it tends toward greater genomic instability and becomes "more and more aggressive," he added. After the gross chromosomal rearrangements soon af...Tiny airborne particles are a major cause of climate change
... atmosphere. This combination prevents atmospheric instability the condition needed to form clouds and rain. A stable atmosphere means fewer clouds; fewer clouds mean less reflection of sunlight; less reflection of sunlight and absorption of radiation lead to warming. Policy makers have argued that, in the bo...The downside to diversification
...ial contribution of V(D)J recombination to genomic instability and cancer formation. V(D)J recombination is the assembly of the immune system's mature antigen-specific receptor genes through the rearrangement of separate V, D and J components in developing B and T cells. The RAG1 and RAG2 recombinase enzymes ca...Most extensive survey ever of world's tropical forests shows upward trend in sustainable management
...cent major armed conflicts. Political and economic instability combined with inadequate enforcement of forest laws have also led to the spread of illegal logging and other forest-related crimes in many parts of the tropics. Wanted: Forests that are Worth More Alive than Dead ITTO advocates the designation of ...OHSU study says stem cell 'fusion' occurs in tumors
... is one explanation for how tumors acquire genetic instability and have the potential to give rise to malignant cancer. One promising result could be in better understanding the careful balance between rapid and effective regeneration after tissue injury, and minimizing the risk of cancer. This balance can be ex...Better model of deadly brain cancer
...ly quite intriguing, too, how this general genomic instability very specifically leads to the selection of tumor cells that have deregulated particular genes such as N-myc , patched and Cyclin D2 . According to Alt, the new mouse model will prove valuable in understanding why N-myc is so frequently amplifi...Pennsylvania researchers find liver transplants provide metabolic cure for rare genetic disease
...n sudden death. Over a patient's lifetime, chronic instability of blood amino acids can result in serious learning disabilities and mental illness. Before transplant, the only treatment was strict adherence to a diet almost devoid of protein. Despite adherence to this diet, patients were still at risk of metabol...Typical pregnancy is now only 39 weeks
... syndrome (RDS), feeding difficulties, temperature instability (hypothermia), jaundice and reduced brain development than full-term babies." The March of Dimes analysis suggests that increasing rates of Cesarean section deliveries and induced labor have probably contributed to, but do not completely explain thes...Genetic factors, neuroticism may be associated with future development of anorexia
...icism, characterized by low self-esteem, emotional instability and feelings of depression, anxiety and guilt. Of these, only neuroticism was identified as a risk factor for subsequent anorexia. "In conclusion, the prevalence of AN increased in both sexes between 1934 and 1958, while consistently afflicting femal......more prone to developing arrhythmias or electrical instability and the blood more prone to clotting. Stress appears to raise heart rate and rapidly hike blood pressure, increasing the heart's need for oxygen-rich blood, Sheps said. Yet less oxygen is supplied, in part because coronary arteries constrict, impedin...