Oncologists could gain therapeutic advantage by targeting telomere protein
...ctioning properly in cells, it can lead to genomic instability and result in the malignant transformation of cells," Pandita says. "In fact, fusions at the telomeric ends of chromosomes like those seen in the absence of Rad9 appear frequently in tumor tissues." The study's findings place Rad9 at an important ju...Little known DNA repair enzyme may be a tumor suppressor gene
...esearch, in that such a high degree of chromosomal instability is a characteristic of cancer cells. Furthermore, the human Rev3L gene is located in a segment of chromosome 6 where multiple tumor suppressor genes are believed to reside and a slew of human cancers, including a number of leukemias and lymphomas, ar...JCI table of contents: December 2005
...moglobin with significant NO inhibition, vasomotor instability and impaired organ function. The data provide evidence for the existence of a human syndrome of hemolysis-associated NO dysregulation, which may contribute to disorders such as sickle cell disease, malaria, anemias, and cardiopulmonary bypass. TIT...Faulty cell cycle checkpoints linked to lung cancer risk in African-Americans
...all DNA abnormalities, which could lead to genetic instability and the development of cancer, Zheng said. To conduct the study, Zheng and her colleagues at the National Cancer Institute collected information as well as blood samples from 216 patients with lung cancer and from 340 cancer-free control participants...Double-trouble: Cells with duplicate genomes can trigger tumors
...a failure of proper cell division produces genomic instability and promotes the development of cancer was first p...te tumors in mice, and these tumors showed genomic instability similar to many human cancers. Another study by Randall King, HMS assistant professor of cell biolog...Double trouble: Cells with duplicate genomes can trigger tumors
...of the cancer-triggering process. Once the genetic instability sets in, tumors "evolve " by losing, gaining and r...atise suggesting, among other things, that genetic instability was a cause of malignant tumors. One way to obtain this lack of chromosomal integrity, Boveri propo...Other highlights in the September 7 JNCI
...ession of the EMSY gene would mimic the chromosome instability found in breast cancer cells that have lost functi...ound that ESMY overexpression induced a chromosome instability phenotype that was similar to that found in BRCA2-deficient cells and conclude that EMSY overexpress...A new view of human-chimpanzee genome differences
... two." Such a difference hints at some chromosomal instability in both species that resolved itself differently in humans than in chimpanzees, he said. Eichler was also intrigued by the data indicating that chimpanzee-only or human-only duplications tended to occur near regions of shared human-chimpanzee duplica...New gene associated with Fanconi anemia 'explains' hallmark chromosomal instability
...ach and others suspected this hallmark chromosomal instability is associated with defects in caretaker genes that help maintain the integrity of DNA. One reason for this hypothesis is that some already identified Fanconi anemia proteins accumulated in the nuclei of normal cells along with protein produced by the...World-first technology enables study of ancient bacteria
...the Bermuda Triangle becomes unstable; this causes instability of the sea and an explosive mixture of air and methane above. Any ships or planes travelling over the area could sink or catch fire. "So ancient, deep-sediment bacteria may be a key to sustainable energy in the future and to explaining a few disast...Air pollution raises risk for dangerous arrhythmias among people with ICDs
... pollution may act in combination with electrical instability of the heart to increase the risk for ventricular tachyarrhythmias. The data that ICDs collect on episodes of arrhythmias provides a significant resource for understanding the role of air pollution in triggering these events."...Check colon tumors for signs of syndrome, study suggests
...s from each patient were tested for microsatellite instability (MSI), a hallmark of Lynch syndrome. MSI occurs in more than 90 percent of Lynch syndrome tumors. To learn the frequency of Lynch syndrome generally, the researchers tested all the tumors for the presence of MSI. They also used an alternative method...Why do amyloid diseases strike different tissues?
...n, given enough time, their inherent thermodynamic instability will cause some of them to misfold, initiate amyloid deposits in the tissues in which they are secreted, and create disease pathologies. "Once they are out there, they are destabilized, and they form the aggregates that cause the disease," says Wisem...Glowing hearts shine light on heart disease
...uctural heart disease die suddenly from electrical instability arrhythmias and also because the heart fails to ... two-pronged worry in these patients is electrical instability leading to arrhythmias and mechanical dysfunction leading to heart failure. CaM kinase inhibition co...UC Davis researchers discover new link between C-reactive protein, and heart disease and stroke
...a. This creates a vicious cycle, leading to plaque instability and rupture, and ultimately heart attacks and strokes." Work at UC Davis and other institutions has shown that C-reactive protein induces endothelial cell dysfunction, thus promoting plaque formation. C-reactive protein causes endothelial cells to p...Insight into DNA's 'weakest links' may yield clues to cancer biology
... sites, providing new insight into the chromosomal instability found in cancer cells, said the researchers. "If ...uke. "Now, we have been able to mimic some of that instability in yeast cells and can begin to ask whether there is anything special that defines those places wher...Cooperation is keya new way of looking at MicroRNA and how it controls gene expression
... unstable and prone to degradation. This inherent instability is built into the 3' tail of the mRNA in the form of noncoding stretches of RNA called AU-rich elements. Lots of genes, including inflammatory cytokines and cancer-causing oncogenes, have these AU-rich elements built in. AU-rich element degradation ...Important discovery about second most fatal cancer
...s many genes) Frequent but variable levels of DNA instability across different colorectal cancers occurring in members of same family Origin in serrated polyps (considered previously to be completely benign) Colorectal cancer is the second most frequent cause of death due to cancer (after lung cancer) in the ...Yeast network prevents damage by oxygen radicals
...results suggest that endogenous ROS-induced genome instability may contribute to cancer progression," says Dr. Kolodner, professor of medicine with UCSD School of Medicine and member of the Rebecca and John Moores UCSD Cancer Center. "And increased ROS is almost certainly more harmful in cells with acquired muta......ssence, a leaf stretches until reaching a point of instability where it can no longer maintain the strain," Mahadevan says. "Like releasing a reversed plastic lid or part of a cut tennis ball, each leaf folds back in on itself, and in the process of returning to its original shape, ensnares the victim in the mid...