Joslin study indicates insulin receptors play a critical role in promoting islet growth
... 2007 -- A new Joslin-led study has identified the insulin receptor as an important protein that promotes isl...cell growth in mice whose bodies are unable to use insulin properly, or are insulin resistant, a precursor to type 2 diabetes. Since the body's natural respons...JCI table of contents: April 2, 2007
...e such a thing as too much sugar? Treatment with insulin revolutionized the life of individuals with diabetes. However, because insulin acts to lower blood glucose levels, it can cause hypoglycemia (low levels of glucose in the blood), ...Elevated autoantibodies linked to preeclampsia
...ombined with underlying maternal factors including insulin resistance, obesity and inflammation that are magnified during the physiological stress of pregnancy. Elevated levels of AT1-AA are evident in nearly all women with preeclampsia, the researchers report. Blood samples from 29 women with preeclampsia...Phthalates now linked to fat, related health risks
...the first time, is linked to abdominal obesity and insulin resistance in adult males, according to a study by...ce. Of these men, 651 also had fasting glucose and insulin levels required to calculate insulin resistance. The analysis found that, as expected, several pht...Insulin -- in need of some restraint?
...nocking out the gene for a peptide associated with insulin secretion protects mice against the harmful effect...cortin 3, a new peptide recently discovered in the insulin secreting cells of the pancreas, plays a role in the increased production of insulin in response to ...How eating less might make you live longer
...t several biomarkers of aging, including decreased insulin sensitivity (a precursor to diabetes). But how might caloric restriction slow aging? A major factor in the age-related decline of bodily functions is the accumulation of "oxidative damage" in the body's proteins, fats, and DNA. Oxidantsin particular,...Joslin researchers discover a surprising culprit in the search for causes of diabetic birth defects
... well after birth to allow the pancreas to produce insulin and the liver to store glucose, also makes the early embryo take up glucose very efficiently when glucose concentrations are high, as can occur during diabetic pregnancy, this explains why the embryo is so sensitive to the mother's hyperglycemia. "...Joslin study reveals how a specific fat type can protect against weight gain and diabetes
...se develops severe obesity, high blood glucose and insulin resistance with extremely high insulin levels. By contrast, the 129 mouse gains on average 30 to 50 percent less weight on either a high-or...Magic beans -- Anti-obesity soya could help prevent diabetes
...e key problem in type II diabetes is impairment of insulin action, mainly as a result of excess abdominal adipose tissue - so loss of weight often improves glycaemic control, says Dr Bender. Lynne Garton, a registered dietician and nutritionist and consultant to the Soya Protein Association, said: "Soy fit...JCI table of contents -- February 22, 2006
... METABOLIC DISEASE: PKC-epsilon links fat to insulin resistance The accumulation of fat in the liver...ty liver disease, which is associated with hepatic insulin resistance and type 2 diabetes mellitus. However, the mechanisms by which fat accumulation leads to ...JCI table of contents: February 15, 2006
...S), a collection of disorders (such as obesity and insulin resistance) that lead to increased risk of develop... mice with a global PPAR-gamma defect are severely insulin resistant and have less fat than normal mice, although the latter is offset by an increase in the si...Active lifestyle reduces risk of invasive breast cancer
...s include prevention of weight gain, regulation of insulin sensitivity and alterations in immune function. Taking all these factors into consideration, "intervention studies assessing the effect of physical activity on estrogen and other hormone exposure, and other biomarkers of risk would provide valuable...Breakthrough in understanding type 2 diabetes as key genes identified
... known as SLC30A8, which is involved in regulating insulin secretion. Type-2 diabetes is associated with a deficiency in insulin and the researchers believe it may be possible to treat it by fixing this transporter. Professor...A unique twin study on the increased cardiometabolic risk in obesity
... the obese co-twins was associated with whole body insulin resistance, something that could not be detected using classical lipid measures only. ...Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight
...of inflammatory signaling via EP3R with leptin and insulin increase, glucose tolerance, and white fat accumulation, and thus may provide a very important animal model for determining the importance of inflammation in obesity and in the conversion of obesity to type 2 diabetes." Ultimately, better understan...Columbia scientists determine 3-dimensional structure of cell's 'fuel gauge'
...nt, meaning that their cells are not responsive to insulin which normally helps glucose get out of the bloodstream, where it does damage, and into cells. When AMPK detects low levels of ATP in the cell, it works through a different mechanism to increase how much glucose the cell takes in and uses to create A...International consortium to get to heart of coronary artery disease
...k at the extent to which CAD risk factors, such as insulin resistance, hypertension and obesity, can be predicted using biomarkers in the blood. Scientists have already identified biomarkers which, when found in elevated levels, indicate the presence of certain types of tumour. In addition, Professor Gaugu...Standard therapy more effective than diabetes drug in helping women with PCOS achieve pregnancy
...h cysts. Women with PCOS frequently experience insulin resistance, a pre-diabetic condition in which higher-than-normal amounts of insulin are required to allow glucose to enter tissues. Earlier studies had shown that drugs such as metfor...Exercise pivotal in preventing and fighting type II diabetes
... obese child to a person dependent for 20 years on insulin injections, exercise could have a dramatic effect on improving insulin sensitivity." Type II diabetes results from a lack of insulin production and insulin res......ave been implicated in the increased prevalence of insulin resistance and type 2 diabetes that occurs with ag...c activation of the AMPK pathway. "In regards to insulin resistance and type 2 diabetes, having more AMPK activity in our skeletal muscle is probably a good ...