JCI table of contents: Feb. 1, 2007
...reased differentiation of fat cells, and increased insulin resistance (one of the main triggers of type 2 dia...: Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2 AUTHOR CONTACT: Nahum Sonenberg McGill University, Mon...Chromium picolinate shows greater benefits in diabetes care than other forms of chromium
...lin, postprandial insulin, glycated hemoglobin, or insulin sensitivity. The authors concluded the greater bi... an essential trace mineral that helps to regulate insulin function. The chromium picolinate in Diachrome has been recognized as safe by many of the world's le...Weight-loss supplement shows good and bad traits
...cessive fat accumulation in the liver is linked to insulin resistance, a hallmark of Type 2 diabetes. Yet C...s did not consume CLA. The researchers monitored insulin sensitivity in all mice throughout the study. They also monitored levels of adiponectin, a hormone s...Major link in brain-obesity puzzle found
...he ability to sense the signals sent by leptin and insulin that tell the brain to slow down food intake and f...e imbalance is linked to alterations in leptin and insulin signaling that lead to excess weight gain and Type 2 diabetes, respectively, says Rui, an assistant ...Joslin-led study uncovers role of appetite hormone MCH in insulin production
... MCH induces appetite, it simultaneously increases insulin secretion from beta cells and enhances growth of b...orm of the disease, the body doesnt produce enough insulin and/or cant use insulin properly (insulin resistance). Both diseases could benefit from treatments t...UCR involved in discovery of diabetes fighting molecule
...is key molecule, identified as Boc5, can stimulate insulin function in response to high levels of glucose as ...e looking for ways to sensitize sugar-metabolizing insulin by stimulating production of GLP1. Synthetic versions of this peptide have proven effective but of s...Cells passed from mother to child during pregnancy live on and make insulin
...that the mother's cells were attacking the child's insulin cells and no evidence that the maternal cells were...maternal microchimerism results in cells that make insulin - these maternal stem cells could provide new insights into how insulin producing beta cells are gen...New miniaturized device for lab-on-a-chip separations
...oduce a complete immunoassay calibration curve for insulin in a single run. NIST is applying for a patent on the method. ...JDRF forms partnership with MacroGenics
..., anti-CD3 treatment has the potential to decrease insulin requirements, lead to better glucose regulation, a...trial is to assess teplizumab's capacity to reduce insulin requirements, while maintaining relatively normal blood sugar levels. Additional information regard...JCI table of contents: January 2, 2007
...te for the increasing resistance to the effects of insulin by increasing both the amount of insulin secreted and the mass of insulin-secreting cells (beta cells) in the pancreas. Several factors have ...JCI table of contents: Dec. 21, 2006
...rocess and are known to help control the amount of insulin (the hormone that causes energy in the form of glucose to be stored) released by the pancreas. But now, new roles for GIP and GLP1R outside the pancreas have been identified, in mice, by researchers from the University of Toronto. In a study appeari...Buildup of damaged DNA in cells drives aging
...ular by genes that regulate the growth hormone and insulin pathways," said Laura Niedernhofer, M.D., Ph.D., assistant professor of molecular genetics and biochemistry, University of Pittsburgh School of Medicine, and first author of the study. How the researchers came to study the relationship between DNA ...News tips from ACS Chemical Biology
... PTEN is known to play a role in the regulation of insulin signaling. Rosivatz & Wolsholski describe the design, synthesis and biological evaluation of several vanadium-based small molecule PTEN inhibitors, creating a potential starting point for the development of PTEN-targeted anti-diabetic therapeutics. ...Linchpin discovered in insulin metabolism
...'Titch' could play a key role in the metabolism of insulin a completely new role for cytohesins,' Professor ...blood sugar. What is more, however, the cascade of insulin signals also determines size and number of the body cells during growth. Apparently, 'Titch' plays ...Leibniz Prize winners 2007 announced
...etes research. He has demonstrated the role of the insulin receptor in controlling body weight and in the for...egulate food intake. The key control signal is the insulin that regulates the bodys energy status from the brain. Considering the almost epidemic proliferat...From managing sugar to managing healing
...alifornia, Riverside, recently found that applying insulin directly to skin wounds significantly enhanced the...cess. Skin wounds in rats treated topically with insulin healed faster"surface cells in the epidermis covered the wound more quickly and cells in the dermis,...Scientific meeting on pulmonary hypertension, December 7-8
...uding COPD, liver disease, and viral infection and insulin resistance. Future Therapies: Friday, December 8, 8:05 a.m.Panel presentations and discussion with leading researchers and clinicians on novel therapies such as PDGF (platelet-derived growth factor) inhibitors antibodies that target cell division, ...Research yields new insights into the cause of diabetes
...glucose in the blood by producing the precursor of insulin -- proinsulin -- in the endoplasmic reticulum. Ins...anes among the islets, triggering the secretion of insulin in the beta cells. But without the islet architecture, communication among the beta cells breaks do...JCI table of contents: December 1, 2006
...lop. Understanding the molecular pathways by which insulin affects the different cells might provide clues as to why insulin resistance develops. Now, in a study appearing in the December issue of the Journal of Clinical Inve...NYU, Scripps finding offers new path for treatment of diabetes
...ve discovered a new enzyme, GAPDH, which regulates insulin pathwaysa finding that offers a new direction for ... first discovery that GAPDH actively regulates the insulin pathway. The research team constructed all the molecules by incorporating the fishing tag (linker)...