Dragonfly's metabolic disease provides clues about human obesity
...estines may play in human metabolic disorders like insulin resistance, type-2 diabetes, and obesity. In mamm...has been shown to be related to the development of insulin resistance and metabolic disease in humans. "What's more, we could induce this activation in muscle...New test may identify cardiovascular disease earlier
...ravate the body's inflammatory response as well as insulin signaling in diseased arteries." Both such actions, she said, may play a role in cardiovascular disease. Shah's group plans further studies to identify the genes responsible for the metabolomic profiles uncovered in the current study. She also plan...Malaria drug may treat metabolic syndrome's many symptoms
...n human patients very soon. Often associated with insulin resistance, metabolic syndrome can include five co...said. An alternative view is that atherosclerosis, insulin resistance, and the component clinical features of the metabolic syndrome share a common unifying me...Common cause of heart disease, diabetes may be treatable with malaria drug
...inked to a range of symptoms that include obesity, insulin resistance, high blood pressure, low levels of goo... be helping. That chain starts with a link between insulin and a protein known as ATM. Normally involved in the response to stress and repair of DNA, ATM is mu...ACS News Service Weekly PressPac -- Nov. 1, 2006
...drates that do not cause spikes in blood sugar and insulin levels. Those are among the consequences of eating...rts starch into glucose, which triggers release of insulin in the body. Long-term consumption of high-glycemic foods has been linked to diabetes, cardiovascula...Joslin Diabetes Center study examines insulin pump therapy in adolescents
... advantages, there are many challenges to using an insulin pump to treat type 1 diabetes. Despite these chall...can benefit from its advantages." Starting on an insulin pump requires considerable training. Before beginning pump therapy, patients in the study and their ...New behavior may use old genes
...have found that the important conserved pathway of insulin signaling may be involved in deciding whether a bee collects pollen or nectar, Amdam said. According to the genome sequence, these genes which the researchers have found involve regulation of the female reproductive cycle and lifespan in insects a...Diabetes gene carries similar risk to obesity
... genes, and is probably key in the pancreas (where insulin is made to control the sugar levels in the blood), as well as in fatty tissue and the gut. The actual mutation in the gene has not yet been found, and there are likely to be several different mutations acting in different people. It is possible t...New biochip helps study living cells, may speed drug development
...which occur in muscles, neurons and the release of insulin from pancreatic cells. The chip currently can detect individual levels of different ions. Porterfield believes that with some modifications, however, the chip will be able to measure multiple ions at once and perform even more advanced functions s...JCI table of contents: October 19, 2006
...C DISEASE: Triggering TLR4 can raise resistance to insulin Type 2 diabetes is caused by insulin resistance, which occurs when cells do not respond to insulin causing the storage and release of ene...Molecular mechanism provides intra-cellular traffic signal
...ariety of human diseases. For example, problems in insulin secretion or presentation of insulin-receptors on the cell membrane result in diabetes. Defects in growth factor secretion and presentation of their receptors on cells result in cancer. Defects in neurotransmitter release or internalization result in...Commonplace sugar compound silences seizures
... 2DG as an epilepsy management treatment much like insulin is used to treat diabetes." "All the available epilepsy treatments have focused on suppressing seizures," says co-author and renowned epilepsy expert Tom Sutula, a UW-Madison professor of neurology. "There has been hope that [new drugs] will not on...Structure of enzyme offers treatment clues for diabetes, Alzheimer's
...rget for new drugs because it breaks down not only insulin but also the amyloid-beta protein, which has been ...the enzyme he could help diabetics by making their insulin remain active longer. More recently, as scientists realized that IDE was also involved in clearance...Inheriting a tendency to brain infection
...gy for treatment, Casanova said. "It's like giving insulin to a diabetic patient," he said. "You just replace the missing compound." Soon, children who come into the intensive care unit with herpes simplex encephalitis may be treated with both the standard antiviral, acyclovir, and with type I interferon, ...University of Florida study shows leptin could combat type 2 diabetes
...othalamus to keep the body from producing too much insulin even after constant exposure to a high-fat diet, w... we were successful in keeping the blood levels of insulin low at the same time keeping blood glucose levels at a normal range," Kalra said. "In other words, w...UCLA neuroscience research leads to a possible treatment for type 1 diabetes
... characterized by a failure of the body to produce insulin because the immune system attacks and destroys the... was that GAD was also made in the cells that made insulin in the pancreas -- cells that use the chemical transmitter made by GAD to communicate with other pan...Aussie team makes landmark insulin discovery
...ists has determined the molecular structure of the insulin receptor, the protein on the surface of cells that... years of international research to understand how insulin functions in the body. Dr Colin Ward of CSIRO Molecular and Health Technologies and his team have be...Transplant cures rats' type 2 diabetes without need for immune suppression drugs
...splant the cells in a way that lets them grow into insulin producers without triggering attacks by the rats' ... a prediction difficult is the phenomenon known as insulin resistance. Levels of blood sugar are high in type 1 diabetics because insulin-producing pancreas ce...Replacing insulin is top-ranked breakthrough foreseen for health in developing world
Eliminating the need for costly insulin injections for diabetics, regenerating heart muscl...he study placed atop their list: "Novel methods of insulin replacement and pancreatic islet cell regeneration for diabetes." Many panellists noted the heavy...Will stem cell-based treatments make a difference to the developing world?
... The top-ranked application was novel methods of insulin replacement and pancreatic islet cell regeneration...betic ulcers. The panelists noted that repeated insulin treatments are costly and inaccessible to many patients in developing countries. They felt that rege...