Studies find general mechanism of cellular aging
...eatic islet cells. Islet cells are responsible for insulin production and secretion. Because p16INK4a stops cancer cells from dividing and demonstrates increased expression with age, the scientists suspected the gene played a similar role in aging. The researchers developed strains of mice that were either d...Diabetes slows nerve recovery after heart transplant
...t occurs when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. Such a deficiency results in increased concentrations of glucose (sugar) in the blood, ...Disabling a carbohydrate trigger reduces obesity and appetite
...A, MD (August 30, 2006) Until about 15 years ago, insulin was believed primarily responsible for turning car...te glucose metabolism and fat synthesis, even when insulin levels were low or absent. Five years ago, researchers discovered that a substance known as ChREBP ...Long acting insulin makes the grade
... and Ageing has today informed us that long acting insulin has been approved for inclusion on the Pharmaceuti...finally been reached that will see the long acting insulin products madeavailable at a reasonable price to people with diabetes who require insulin. People w...Chemical compounds restore normal glucose levels and insulin action in obese mice
...d TUDCA restored healthy glucose levels and normal insulin action - and reduced the presence of fatty liver d... deaths a year. Obesity is closely associated with insulin resistance and is one of the leading risk factors for type 2 diabetes. The molecular mechanisms that...Toxic molecule may cause most common type of muscular dystrophy
...of the muscles, irregular heartbeat, cataracts and insulin resistance. Many people don't know they have MMD until their teens or twenties. To prove the theory that toxic RNA is involved in myotonic muscular dystrophy, a research team led by Dr. Mani Mahadevan, a UVa pathologist, duplicated the disease i...Study aims to identify schizophrenics at risk for type 2 diabetes
...esity, high lipid and cholesterol blood levels and insulin resistance, is better than 50 percent in women and...an increased rate of impaired glucose tolerance or insulin resistance, a hallmark of diabetes. "It's not 100 percent, it just changes your risk; bad things in ...JCI table of contents: August 17, 2006
...n part, because of impaired negative regulation by insulin of the forkhead transcription factor FoxO1, which induces the expression of several genes that encode enzymes that promote glucose production in the liver. Despite this knowledge, researchers have yet to identify the part of FoxO1 that is necessary f...Scientists discover age-regulated cellular activities that protect against protein aggregation
...ly reduced" when aging is slowed by modulating the insulin growth factor (IGF) signaling pathway. Moreover...expected to see less aggregation in the worms when insulin signaling was inhibited. In fact, what they saw was more. Teasing apart the results, the researche...New research points toward mechanism of age-onset toxicity of Alzheimer's protein
... the data revealed a surprise: "Worms with reduced insulin signaling seemed perfectly fine although they had high molecular weight aggregates, while worms with an accelerated aging program were extremely sensitive to the toxic effects of beta amyloid but we couldn't detect any large fibrils," explains postdo...Joslin awards Victory Medal to New York man living 75 years with type 1 diabetes
...lood glucose levels, doing calculations to balance insulin with food intake, and the many, many injections, have paid off," Bates says. Bates continues to participate in clinical research at Joslin to help others with diabetes. In March, he came to Joslin to participate in the Medalist Study, which began...Insulin pathway component explains insulin resistance, age-associated metabolic syndrome
... aging-associated group of disorders that includes insulin resistance, heart disease and high lipid levels, m...hey also blocked the function of another important insulin regulator, a factor called FOXO, which is known to be a critical mediator of insulin signals and the......d use the artificial islets of Langerhans to study insulin release, but also to test diabetes treatments or even potentially to use as implants for people with defective islets. The quest for synthetic blood Transfuse the wrong blood type and the patient's immune system may destroy the new blood cells,...JCI table of contents: August 1, 2006
... or damaging them sufficiently to reduce or impair insulin production. Therefore, shutting down the autoreactive T cells that attack beta islet cells is one therapeutic approach that researchers have been investigating. A molecule named cytotoxic T lymphocyteassociated antigen 4 (CTLA-4) is known to prevent ...JCI Table of Contents: July 13, 3006
...s of fatty acids and has been previously linked to insulin resistance in diabetes and the development of atherosclerosis. This new study suggests that in addition to its role in type 2 diabetes and hardening of the arteries, aP2 plays an essential role in allergic airway diseases such as asthma, and offers a...UF study sheds light on cystic fibrosis-related diabetes
...ystic fibrosis patients with diabetes produce some insulin on their own, but they require daily injections to...y. At times they also become very resistant to the insulin they do make, similar to people with type 2 diabetes. "For the longest time, the development of di...Mutation in tumor suppressor gene causes pancreatic islet cells to reproduce
...iferation of pancreatic islet cells, which secrete insulin to regulate blood sugar. The menin gene (Men1) mut...s is the leading reason why a sufficient amount of insulin cannot be produced. "If we could eventually repress menin function to specifically stimulate beta-ce...Fat-generated hormone drives energetic capacity of muscle
...people and mice, linking low adiponectin levels to insulin resistance and reductions in the number of "cellul...signal might prove beneficial for the treatment of insulin resistance and diabetes, they said. "We have discovered a skeletal muscle pathway by which adipone...JCI table of contents: June 22, 2006
...ese neurons interact with. The hormones leptin and insulin are two such fuel-sensing chemicals and the intracellular pathways via which they signal intersect at an enzyme known as PI3K, which produces the messenger protein PIP3. Brning and colleagues examined the role of PIP3-mediated signals in hypothalamic...Chewing up a key regulator of fat synthesis keeps mice lean despite a high-fat diet
...sease, a serious problem in obese individuals with insulin resistance," says Montminy. Our body's ability to ...ce known as "metabolic syndrome." Most people with insulin resistance will develop type 2 diabetes within 10 years, unless they lose 5 to 7 percent of their bo...