Tag: "insulin" at biology news
Teasing out tissue from blood
...ytes into pancreatic islet-like cells that produce insulin
in response to high levels of glucose. "We now want to transplant these cultures into a diabetic mouse model," says Winnier, adding their results are being prepared for publication in a peer-reviewed journal. Alan Colman of ES International, a compan...
Pancreas bioengineering at the MUHC receives funding boost
...t occurs when the pancreas does not produce enough insulin
(type 1 diabetes) or when the body cannot effectively use the insulin
it produces (type 2 diabetes). Most people with diabetes have type 2, which also includes a loss of ...
Successful transplantation from pig embryos to mice
...face a lifetime of daily injections to replace the insulin
their bodies fail to produce, as well as a host of...tes, transplants of the pancreatic tissue in which insulin
is produced might alleviate these problems. Unfortunately, there are not nearly enough organ donors ...
The molecular mechanism of a diabetes vaccine revealed
...ucing and ultimately eliminating the production of insulin
a hormone needed to convert sugar, starches, and other foods into energy. Several years ago, Prof. Cohen and colleagues developed a vaccine that arrests the progression of Type 1 diabetes in laboratory animals. They had discovered that a particular ...
Researchers find new clues to biochemistry of 'anti-aging'
... aspects of metabolism responsible for controlling insulin
secretion." Denu and his team, which has published widely on sirtuins, conducted test tube studies using mouse cells to learn exactly which molecular players sirtuins act on directly. Previous studies suggested that sirtuins control genes indirectly ...
Long-term study shows brain function not impaired by tight diabetes control and hypoglycemia
... tight control -- achieved by taking three or more insulin
injections daily -- can come at a cost: Patients i...atients receiving intensive therapy with either an insulin
pump or three or more daily insulin
injections; and 522 patients receiving conventional therapy of o...
Joslin discovers signs of residual islet cell function in people with long-term type 1 diabetes
...edalists still have c-peptide secretion, a sign of insulin
production, and some are positive for antibodies t... 125 people with type 1 diabetes for biomarkers of insulin
function. Of this group, 12.7 percent had a c-peptide level greater than 0.3 ng/mL, which indicates ...
Bacteria have their own immune system protecting against outside DNA
...for medicine and research. These proteins, such as insulin
or human growth hormone, are created when a piece of human DNA corresponding to that protein is introduced into bacteria. The bacteria then reproduce many times over, creating more of the protein each time they reproduce. The proteins are purified ou...
Diabetes research takes wing thanks to long-lived fruit fly
...at responds to stress and works in tandem with the insulin
receptor that is central to diabetes. They recentl...JNK targets the same protein as the widely studied insulin
receptor, central to human health and to the disease process that underlies diabetes. The finding ha...
Hopkins researchers discover potential new approach to treating diabetes
...a really big problem, even when patients are given insulin
and stay on strict diets," says Carles Lerin, Ph.D., a postdoctoral fellow in cell biology at Hopkins and an author of the report. "In the absence of a cure for the disease, we are really trying to focus on finding better treatment because currently ...
Increased sensitivity to nerve signals keeps diabetes at bay
..., including impaired glucose tolerance and reduced insulin
release, the authors report. M3 receptors are norm...site: a profound increase in glucose tolerance and insulin
release, the researchers found. Moreover, such animals become resistant to developing symptoms of di...
Gardenia fruit compound starting point for diabetes therapy
...body's main energy source. In those with diabetes, insulin
deficiency or insulin
resistance causes blood sugar concentrations to rise. The team discovered that Gardenia extract cont...
Biological diversity and human health; Rapid autopsy program; Snake bites and more
...if such a process actually exists (in the way that insulin
corrects diabetes). Citation: Moncrieff J, Cohen D (2006) Do antidepressants cure or create abnormal brain states? PLoS Med 3(7): e240. PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://dx.doi.org/10.1371/journa...
JCI table of contents, June 1, 2006
...ke counterregulatory measures including decreasing insulin
secretion, and increasing glucagon and epinephrine...lycemia has become a major limitation to effective insulin
therapy in type 1 diabetes. In a study appearing in the June issue of the Journal of Clinical Invest...
Joslin researchers pinpoint causes of adverse reactions to popular type 2 diabetes drugs
...pe 2 diabetes head on by helping patients overcome insulin
resistance, but because of its complications, it has had limited clinical use in patients with diabetes and heart disease," says Dr. King. "There is now a potential way to make this drug more widely available." Other Joslin researchers participating ...
Research suggests cause of neurodegeneration in Huntington's disease
...ished an article identifying HAP1s role connecting insulin
to the hypothalamus in the journal Nature Medicine. "This protein is very important," says Dr. Li. "When an animal does not have HAP1 it dies after birth. Certainly, it's essential for differentiation and survival of some neurons in the brain." In...
ACS weekly press package May 8, 2006
...rochemical industries Summer's medical milestone: insulin
without the injection Journalists' Helper of the ...istration in January, Exubera is the first form of insulin
that can be inhaled. It's the answer to an 85-year-old quest for a more convenient way of administer...
Enzyme defect leads to hyperinsulinism
...tal hyperinsulinism appear to be due to defects in insulin
secretion by pancreatic cells. Currently, it is th...hydrogenase, which in turn triggers the release of insulin
from pancreatic cells. "The glutamate dehydrogenase mutations that cause hyperinsulinism are amino a...
JCI table of contents, May 18, 2006
...cells in the pancreas, which leads to insufficient insulin
secretion and high blood glucose levels (hyperglycemia). Currently, insulin
secretion is used as a surrogate measure of beta cell mass. However serum insulin
Joslin-led study reveals new findings on insulin signaling in the liver
...e and lipids in the blood. We now understand that insulin
that controls the pathways that control glucose le...ut, until now, researchers have not understood how insulin
does its job. "In one of its roles, insulin
tells the liver that you have just eaten, that it can s...
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