JCI table of contents: Jan. 18, 2007
...ion in CFTR (the S13F mutation) prevents CFTR from interacting with proteins known as filamins, which are essential for maintaining CFTR at the cell membrane. In the study, which appears online on January 18 in advance of publication in the February print issue of the Journal of Clinical Investigation, Sharon M...Scientists reveal secrets of Homer's Cyclops to help people with Holoprosencephaly
...he authors describe how a known mutation of the TG interacting factor (TGIF) gene, called TGIF.P63R, causes Holoprosencephaly, which affects brain and skull formation. In particular, researchers found that this mutation not only does not produce the protein necessary for healthy fetal development, but the mutant...'Geological Approaches to Coral Reef Ecology'
...term trend or cycle. The contributions examine the interacting causes of change, which include hurricane damage, regional outbreaks of coral-consuming predators, disease epidemics, sea-level rise, nutrient loading, global warming and acidification of the oceans. Crucial predictions about the future of coral reef...York-Sichuan link to study biodiesel production
...y the award and very excited by the opportunity of interacting with Chinese scientists in this very important area."...Complexity constrains evolution of human brain genes
...within the brain. "We know that proteins with more interacting partners evolve more slowly," Wu said. "Mutations that disrupt existing interactions aren't tolerated." Although the gene sequences from human and chimpanzee remain very similar, previous studies in tissues other than the brain have shown that gene...Treatments for urinary infections leave bacteria bald, happy and vulnerable
...membrane, and many of its most important tools for interacting with the outside world are assembled in the space between the membranes," Pinkner explains. A molecule known as the chaperone protein takes the parts of the pili from the inner membrane to their assembly site on the outer membrane. Hultgren's group ...With fruit fly sex, researchers find mind-body connection
...ehavior. Other scientists have found that a web of interacting genes control courtship and receptivity. McKeown wanted to settle the debate. McKeown suspected that multiple genes shape behavior and that doublesex played a role. But experimenting with doublesex is difficult. When both copies of the gene are rem...News tips from the Journal of Neuroscience
...with alsin, they fished out the glutamate receptor interacting protein 1 (GRIP1), whose role is to shuttle the AMPA receptor subunit GluR2 to the postsynaptic membrane. In neurons from ALS2 -/- mice, neither GRIP1 nor GluR2-containing AMPA receptors made their way to the synapse. This is not inconsequential bec...Insect population growth likely accelerated by warmer climate
... population growth rates of the species living and interacting in those ecosystems. She noted that biochemical adaptation to warmer temperature is not the only possible insect response to climate warming. Some species might evade warmer temperatures by moving to cooler habitats, or they might alter their seas...Pollinators help one-third of the world's food crop production
...y co-authored another study showing that wild bees interacting with honey bees can lead to a five-fold increase in pollination efficiency. "The problem is, if we don't protect the wild pollinators, we don't have a backup plan." Kremen suggested an approach to a more sustainable form of agriculture, one that de...Otherworldly bacteria discovered two miles down
...ct that because the chemical signature arises from interacting with the fracture's wall rock," commented Rumble. "It is possible that communities like this can sustain themselves indefinitely, given enough input from geological processes. Time will tell how many more we might find in Earth's crust, but it is esp...Caterpillars tell us how bacteria cause disease
... leading the study, explained: "Bacteria have been interacting with simple animals such as amoeba and insects for a staggering length of evolutionary time. It seems likely that most virulence genes around today probably first evolved to work against these hosts". With funding from the Biotechnology and Biologi...Nanoparticle assembly enters the fast lane
...partially rigid, double-stranded DNA, which forces interacting linker segments of DNA to extend away from the gold surface, allowing for more efficient assembly. "By using properties of DNA, we can increase assembly kinetics, or speed, by relatively simple means without a lot of synthetic steps," Maye said. ...CSH Protocols publishes cutting-edge methods for analyzing complex molecular interactions
...ready been successfully employed in characterizing interacting proteins in yeast. These methods are among more than 40 new peer-reviewed protocols added to the CSH Protocols database this month. Launched in May of 2006, CSH Protocols now includes more than 700 protocols spanning many fields in cell and mol...When two mutants collide: How XPD disorders can be partially rescued in compound heterozygotes
...e disease symptoms and improve the function of the interacting genes. Each of these disorders has distinct manifestations and associated risks, and in mice, some of the same physical traits are apparent. An existing "monoallelic" paradigm states that mutations either cause a specific XPD syndrome, or they don'...Inheriting a tendency to brain infection
... are complex, involving different genetic variants interacting with each other and with the environment in subtle ways that add up to an overall predisposition or resistance. However, Michael Levin, professor of pediatrics and international child health at Imperial College, London, does not think the two the...Structure determined for key molecular complex involved in long-term gene storage
...the structure of these molecules communicating and interacting with each other, and it provides important insights into their function." "By defining some of the rules that dictate how these complexes are formed and operate, we have revealed a part of the difference between growing and non-growing cells," says ...Cell's fight against cancer revealed
...this oncoprotein (LTag) to target it by physically interacting with it and changing its conformation," Chen said. If the virus succeeds, the result is a new tumor....Chimpanzees can transmit cultural behavior to multiple 'generations'
...al group was allowed to observe the process before interacting with the testing box. Once the second animal succeeded, another chimpanzee would enter and observe the technique, and so on down the chain. In the two social groups trained to slide or lift the door, the technique used by the original animal was pass...Study provides insight into how the brain loses plasticity of youth
...mmune cells which cells to attack. They do this by interacting with a large number of receptors found on the surface of immune cells. Syken, Shatz and colleagues wondered whether such receptors might also be expressed in neurons and involved in MHC Class I-mediated synaptic plasticity. Using a method called in...