When the going gets tough, slime molds start synthesizing
...hout nature. Organisms use chemicals as a means of interacting with their surroundings and mankind has exploited this fact to discover the vast majority of pharmaceuticals used to treat disease today. "The major fundamental question in our case is why do organisms make chemicals, what role do these molecules pla...Defense peptide found in primates may block some human HIV transmissions
... is unclear, but it may be a result of retrocyclin interacting with more than one target on both the cell and virus. Viruses that have to defeat more than one antiviral mechanism often develop resistance at a much slower pace. The next phase of Cole's research will delve more into the mutations that HIV-1 can ...Researchers devise new tools to help pinpoint treatments for heart failure
...utational models get a better understanding of the interacting biochemical pathways in heart cells that involve PKA," said Andrew McCulloch, a professor and chair of the Department of Bioengineering at UCSD's Jacobs School of Engineering. "Now we're in a good position to do similar experiments with mutant strain...Meth promotes spread of virus in HIV-infected users
...nswer. "Since meth mediates its effects through interacting with dopamine receptors present on the cells, and meth increases DC-SIGN, which are the HIV attachment receptors, use of dopamine receptor blockers during HIV infection in meth users could be beneficial therapeutically to reduce HIV infection in the...Story tips from the Department of Energy's Oak Ridge National Laboratory, August 2006
...w computational method to identify networks of the interacting genes that underlie complex traits. Brynn Voy of ORNL's Life Sciences Division led a team that has developed a method to convert massive amounts of gene expression data into graphs and extract sets of perfectly interconnected genes called cliques. Th...Opportunities for structured doctoral research
...rative systems from biology and medicine and their interacting and heterogeneous subsystems. (Spokesperson: Professor Adeline Maria Uhrmacher, University of Rostock) How groups of mobile "intelligent" devices, such as laptops and video projectors, can interact to achieve common goals and support the user, is t...Watching rocks grow: Theory explains landscape of geothermal springs
...ime. Hot springs comprise a complex ecosystem of interacting microbes, geochemistry and mineralogy. The rapid precipitation of calcium carbonate results in shifting flows, and in the sealing off of some springs and the eruption of new vents. "Now that we understand the physical processes involved in how thes...Medium is the message for stem cells in search of identities
...l in the body, acquire their identities in part by interacting with their surroundings - even when they are outside of the body in a laboratory dish, University of Florida scientists report. Using an animal model of embryonic stem cell development, researchers with UF's McKnight Brain Institute have begun to an...Breast cancer genetics and more -- press release from PLoS Medicine
... hence the researchers believed that defects in an interacting protein might have a similar effect. The researchers found that the Cys557Ser allele was nearly twice as common in women with breast cancer as in control women, although the absolute frequency remains small -1.6% in controls versus 2.8% in women with...Report focuses on the role good microbes play in future medicine
...ase through a number of mechanisms. One way is by interacting directly with the disease-causing microbes, making... disease. Probiotics also help prevent disease by interacting with and strengthening the immune system. "Exposure to commensal organisms is necessary for the a...Large-scale genomics project will hunt genes behind common childhood diseases
... thought to involve the contributions of multiple, interacting genes. The Center's researchers will then work to translate the genetic knowledge into precisely targeted treatments for the diseases in question, customizing treatments to a child's genetic profile. "We are following a trail blazed by the Human Geno...Scientists uncover new clues to limb formation (and loss) in some sea mammals
...of genes is at work at different times, delicately interacting to form a limb with muscles, bones, and skin. The genes are similar to the runners in a complex relay race, where a new runner cannot start without receiving a sign from a previous runner." In dolphins, however, at least one of the genes drops out ea...JCI table of contents, May 18, 2006
...l cytokine production was mediated by beta-glucans interacting with a protein called dectin-1, and most likely in cooperation with Toll-like receptor 2. This study will serve as a model for future studies of how the immune system recognizes other microorganisms. TITLE: Immune sensing of Candida albicans requires...Robots manipulating animal behaviour
... competitiveness and a decrease in costs. "A robot interacting with animals, even if it is not mobile, could be used for numerous tasks, such as herding or milking. Our project demonstrates that the fields of biology and IT can work together more closely in future." Though the project has officially ended, some ...Ethnobotanist says non-regulated herbs pose risks
...e well being of the patient, or how these might be interacting with pharmaceuticals that are being prescribed. Ideally this information might eventually be inserted into a data base which would provide the answers needed. "I would urge that medical schools sponsor continuing education programs on the subject, ...Plants' role in global warming re-examined in ORNL Science paper
...s upon having a thorough understanding of multiple interacting factors, including plant respiration. "The fact is that plants adapt to higher temperatures and their levels of respiration adjust downward." While some previous climate-carbon simulations have included differentiation among vegetation types, none ha...NIH awards $13.3 million to Carnegie Mellon, University of Pittsburgh
...s, we can study in detail how all the proteins are interacting with each other in real-time in the 3-D space of a living cell." Effectively using these intracellular fluorescent probes and biosensors will require an array of current and new detector technologies, according to Simon Watkins, co-director of the C...News tips from The Journal of Neuroscience
...ry for LTD and for interaction with PICK1 (protein interacting with C kinase 1). The authors transfected GluRδ2-deficient PNs with various deletion mutants. The PDZ (postsynaptic density 95/Discs large/zona occludens-1)-binding region was not required for localization to dendritic spines or for LTD. A mutan...Genomatix technology facilitates de novo identification of new renal disease associated genes
...romoter structures which can be used to find novel interacting molecules. Here, these principles are applied to a set of genes linked to the unique functional unit of the glomerular slit diaphragm. An evolutionarily conserved promoter model was generated. Genome-wide scans using this promoter model effectively p...HIV accessory protein disables host immunity via receptor-protein intermediary
.... "The glucocorticoid receptor-Vpr complex must be interacting with something else." The team, led by first author Muthumani Karuppiah, PhD, Senior Research Investigator, looked for molecules with which the glucocorticoid receptor-Vpr complex would bind and identified PARP-1, another protein that controls the ...