Abnormal fat metabolism underlies heart problems in diabetic patients
...ipin, they malfunction. Their malfunction not only interferes with the energy supply of heart muscle cells, it also increases the amount of damaging oxygen-containing substances in the cells, creating unhealthy conditions that can lead to heart problems. Interestingly, a rare genetic disorder Barth syndrome h...Penn researchers discover how key protein stops inflammation
...ation from the body and, in response to infection, interferes with p50 degradation to decrease inflammatory response. Inflammation is natural, says Chen. If we didnt respond to infectious agents, bacteria would kill us. However, the inflammatory response must be controlled or we could also die. Bcl-3 helps re...Gene variant increases risk of blindness
...etailed central vision. Degeneration of the macula interferes with important tasks such as reading and driving. Age-related macular degeneration (AMD), the cause of which is poorly understood, is the leading cause of visual loss in older people and the commonest cause of blindness in the USA and European cou...Study explains how pathogens evolve to escape detection
...B that includes an E3 ubiquitin ligase enzyme that interferes with the plant's surveillance. "This paper provides molecular data that supports the evolutionary 'arms race' theory" that as pathogens develop new ways to spread and attack organisms, the organisms in turn create novel defenses, each in a continuous...Scientists gain important insights into acute promyelocytic leukemia
...A, acts as a potent transcriptional repressor that interferes with gene expression and prevents normal differentiation of white blood cells. Previous work of these two groups suggested that PML/RARA self-association, called homodimerization, and posttranslational modifications are important for transformation. ...New compound effectively treats fungal infections
...by blocking their ability to make proteins. AN2690 interferes with an enzyme called leucyl-tRNA synthetase, which is involved in translation, one of the last steps in the process of turning a genes DNA code into a protein. The process begins when the cell makes an RNA version of the genes code, called messenger...Autism-related proteins control nerve excitability, researchers find
...ecrease in excitability, showing that the mutation interferes with the stability of the synapses, Dr. Kavalali said....New screening method to help find better biofuel crops
... high), corn, and poplar and willow trees. Lignin interferes with enzymatic conversion of polysaccharides to ethanol, so Smith will use the imaging to help select plant stocks that have low lignin content. We hope to find out if lignin content changes over time, with different growing conditions, or with dif...New research shows sharks use their noses and bodies to locate smells
...g to the researchers, streptomycin, an antibiotic, interferes with the normal function of motion sensitive "hair cells," the receptor cells of the lateral line. At high doses it has been known to cause hearing and equilibrium problems in humans, senses that are also based on hair cells. Sharks with their lat...How plague-causing bacteria disarm host defense
...disrupting the host cell's normal structure, which interferes with the cell's innate ability to engulf and destroy invading bacteria. "The question now becomes, why is Gaq targeted by YpkA"" ...MIT-led team uncovers malaria mechanism
...ges. But when RESA binds to the network, it likely interferes with the proteins' ability to break and form bonds with each other, decreasing deformability, according to Suresh. In an unrelated parallel study, researchers at the New York Blood Center and their collaborators have recently identified specific site...Soy estrogens and breast cancer: Researcher offers overview
...ive tumors. They also found that dietary genistein interferes with treatments, such as tamoxifen, that target estrogen receptors in breast tumors. (About 70 percent of women with breast cancer have estrogen-responsive tumors.) "The resolution of this paradox may lie in the timing of estrogen administration," ...Wellcome Trust and GlaxoSmithKline announce partnership to target drug-resistant hospital infections
...membrane surrounding the bacterial cell wall which interferes with drug penetration. New medicines must not only be toxic to the pathogen, but must first overcome the barriers to entry into the cell. The resistance of various types of bacteria to treatment is creating new challenges in the management of infe...Protein found that slows hepatitis C growth in liver cells
...esearchers have identified a cellular protein that interferes with hepatitis C virus replication, a finding that...tivation and the specific mechanisms by which PAK1 interferes with the ability of hepatitis C to hijack liver cells and make more copies of itself. Our findings...Study shows metabolic strategy of stressed cell
...with hopantenate (HoPan). HoPan is a chemical that interferes with pantothenate kinase (PanK), the enzyme that triggers the first step of CoA production. Following the shutdown of CoA production, the cells quickly recycled CoA from other jobs so it could concentrate all its efforts on a single task: extracting ...Pacific Rim researchers to collaborate on distributed bioinformatics analysis of avian flu
... pathways for clues to understanding how avian flu interferes with human metabolism." The Asian institutions all members of PRAGMA will host some U.S. students and researchers, while taking responsibility for specific tasks: JLU will support the scheduling of multiple clusters (CSF4) to distribute jobs t...Cells use 'noise' to make cell-fate decisions
...he random nature of such fluctuations within cells interferes with the reliable operation of biological systems. However, Dr. Sel's research team hypothesized that noise in one particular genetic circuit might be beneficial, linked to a process that controls cell fate. To determine the biological role for noi...Bacterial walls come tumbling down
...uman body, the new understanding of exactly how it interferes with bacterial enzyme function should help scientists design modified versions that are more suitable for use in people. Understanding the structure of this enzyme should also speed up screening and design of new antibiotics, which are in constant ...Remicade therapy shown to improve productivity in patients treated for chronic plaque psoriasis
...rapies, which may help manage a disease that often interferes with work and life activities." In September 2006, REMICADE was approved in the U.S. for the treatment of adult patients with chronic severe (i.e. extensive and/or disabling) plaque psoriasis who are candidates for systemic therapy and when other...New study shows promise of toxicogenomics in environmental monitoring
...ch are needed to break down starch and as a result interferes with digestion. They also found that exposure to copper decreased the activity of genes that encode glucan binding proteins and lectins, which are possibly involved in the water flea's ability to recognize an infection. "It's possible that the decr...