Single genetic defect links many risk factors for heart disease and stroke
...s amino-acid cargo, which can then be incorporated into the elongating protein chain. The defective base the researchers pinpointed was in the gene for the tRNA that transports the amino acid isoleucine. That defect distorted the docking region of the tRNA, preventing it from recognizing and attaching to...Researchers discover gene mutations for Parkinson's disease
...forms of a disease has often led to major insights into the pathogenesis of more common forms. The finding was published online by Neuron at noon ET on October 22, 2004. The collaborative work was spearheaded by Andrew Singleton, Ph.D., at the NIA, Jordi Perez-Tur of the Institut de Biomedicina de Valenc...Genetics play role in response to most common asthma drug
...eeded to determine how to integrate these findings into clinical practice. In the future, patients with the arginine genotype might even be advised to use an alternate reliever medication." The National Asthma Education and Prevention Program (NAEPP) recommends quick-relief medication such as inhaled alb...Gene for common form of Parkinson's pinpointed
...ns underlying rare forms of PD had yielded insight into PD and aided design and testing of drug treatments. Until their studies, it was only known that PARK8 was caused by a mutation in a gene somewhere along a chromosomal region, or locus, that contained about 116 genes. The researchers had identified ...Latest buzz in research: Intoxicated honey bees may clue scientists into drunken human behavior
...briated bees could give researchers better insight into alcohol's effects on human behavior, a new study s...r Neuroscience conference. Honey bees were secured into a small harness made from a piece of drinking straw. The researchers then fed bees solutions of sucr...Reductions in blood oxygen levels in newborns could contribute to ADHD development
...o bursts of compressed air. Once the rats matured into juveniles, the scientists studied their locomotive activity and brain dopamine levels. They found that juvenile rats exposed to brief reductions in oxygen during their neonatal period had a 50 percent reduction in release of dopamine and were hypera...Brain differences in adolescents, psychopaths, lend to their impulsive, risk-taking behavior
...s lower anxiety, while extension of the rat's head into the open area without actually entering it (stretc...scent rats were more likely to extend their bodies into the anxiety-provoking areas than prepubescent rats. Adult rats demonstrated similar extension behavi...... Cells of the cerebral cortex are arranged into functional units called mini-columns. Each of these tiny vertical structures is made up of about a hundred neurons that act as a cohesive unit. The axons and dendrites, which neurons use to send and receive information, form fiber bundles that connec...Early life stress harms mental function and immune system in later years
...Neuroscience annual meeting in San Diego Insight into one potential mechanism comes from studies showing how maternal care can induce alterations in gene methylation in offspring. Other new research is uncovering how stresses during pregnancy and early life can affect learning and memory, as well as imm...Pesticides may promote Parkinson's disease and exercise may offer protection
SAN DIEGO, Oct. 24 -- New research into Parkinson's disease is helping scientists better u...agonist (a drug that tricks certain receptor cells into thinking they have been activated by dopamine). Unlike other dopamine agonists, rotigotine is delive...Retinal stem cells can regenerate after transplant
...e shown that human retinal stem cells transplanted into the eyes of mice and chicks can successfully regen...velopment of transplanted human retinal stem cells into light-sensing photoreceptor cells and retinal pigment epithelial (RPE) cells, the cells which bounce...Sandbagging cancer in the bloodstream
... them to find their way out of the bloodstream and into a metastatic site," says Immunology Professor Davi...cell junctions so that they can implant themselves into a new organ site. In the latest issue of the Journal of Cell Biology, Cheresh, Weis, and their colle...Potential new oncogene may be missing link in cancer-causing chain
... the researchers introduced these aggressive cells into mice, the animals developed tumors twice as large as those caused by the original, slow-growing cancer cells. Having seen the effect of high-levels of LRP6 in laboratory experiments, Bu and his team looked for higher-than-normal LRP6 gene activity in...Study at Joslin shows ease of introducing technology to kids with diabetes
...in Clinic in Boston. The participants were divided into two groups: the Game Group and the Control Group. ...e readings, insulin doses, and carbohydrate intake into the PDA, and transmit the data daily. The Game Group participants, however, were instructed to acces...Cars, not crops, should be chief targets in reducing greenhouse gases
... a quarter of the world's carbon dioxide emissions into the atmosphere, even though we constitute only 5 percent of the world's population," said Jackson, a professor of environmental science and biology who is also director of Duke's Center on Global Change. "Our goal was to compare two different s...Farmers don't need a new superstar toxin to fight bugs
...moderately effective genetic modification inserted into crops specifically to kill resistant insects that survive in the refuge can lengthen the usefulness of the primary genetic protectant used in the main field, Pittendrigh said. These specially designed refuge-area protectants create a phenomenon calle...Bug's-eye-view of urinary tract reveals E.coli infection genes
...0 days trying to get 40 laboratory mice to urinate into little plastic tubes. Snyder's goal was to extrac...y sterile, we knew that the E.coli bacteria we put into the bladder was what would come out in the urine. But it was very important to collect every drop of...Insects implicated in the evolution of new human infectious diseases
...harmless to humans, but which could evolve quickly into a range of new diseases. As part of their research... Waterfield. "As well as passing microbes directly into our bloodstream when they bite us, insects can also act as a reservoir to 'cook up' future human dis...Psychologist finds instance where 'two wrongs do make a right'
...ory holds that information from the eyes separates into two distinct streams: one to simply represent wher...ete picture of how the brain converts visual input into motor output, Dassonville says, these findings enhance our understanding of the most fundamental con...Children's Hospital Boston geneticist awarded for research on muscular dystrophy
...apy using muscle stem cells that graft themselves into diseased muscles and deliver normal dystrophin genes. "We all have the natural capacity to regenerate muscles," Kunkel says. "Why not make use of that regenerative capacity and use it to deliver missing genes?" Using this approach, his lab has gott...