Tag: "investigational" at biology news
Amgen investigational therapy, AMG 162, increased bone mineral density with twice yearly injection
... twice yearly injections of AMG 162, the company's investigational
therapy for bone loss, significantly increased bon...elopment, Amgen. "These Phase 2 results with our investigational
agent are very compelling and give us great confidence as we actively enroll and initiate our pivota...
Study is looking at ways to help stroke survivors regain lost motor skills
...ical procedure, involving the implantation of tiny investigational
electrodes on the surface of the brain, in hopes o... affected. Participants randomized to receive the investigational
device then have an electrode placed on the protective membrane over the area of the brain identifie...
Genetically endowed worm may substitute for rodents in some toxicology testing
...part of a new initiative to broaden and refine its investigational
methods, NTP is extensively evaluating C. elegans' potential value to developmental toxicology. "We know basically everything about the development of this particular organism through its entire lifespan," said NTP associate director Ch...
First human trial of bioartificial kidney shows promise for acute renal failure
...tly underway at six academic medical centers under investigational
new drug, sponsored by Nephros Therapeutics Inc. The study is expected to expand to additional centers later this year. UMHS researchers also have planned, for late 2005, a phase I/II trial to investigate the safety of the RAD for people with end-sta...
Loyola begins study on blood substitute in trauma patients at the scene of injury
...he national clinical trial using PolyHeme®, an investigational
oxygen-carrying blood substitute designed to increase survival of critically injured and bleeding trauma patients at the scene of injury. Loyola has been involved in extensive public education, staff education and paramedic training since its Instit...
Stretching the supply of flu vaccine: Solution offered in new SLU research in New England Journal
...rectly into the muscle. A second group received an investigational
vaccine by GlaxoSmithKline Biologicals intradermally and with a dose that was 40 percent of the standard dose. Belshe said when compared with the full dose of vaccine given as the traditional shot, antibody responses to a lower dose vaccine given und...
The Molecular Profiling Institute named US provider of genetic breast cancer test
...r clinical purposes. It should not be regarded as investigational
or for research. The laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) as qualified to perform high-complexity clinical testing....
Nuclear imaging of iodine uptake in mouse tissues
...ab and CWM-built medical imaging system to perform investigational
studies of mice. Bob Welsh, a jointly appointed professor, is one researcher working on the project. Their work shows that scientists can learn about how the body uses certain substances of interest such as insulin, the fat-regulating protein leptin...
JLab, College of W&M researchers study radiation blockers
...ab and CWM-built medical imaging system to perform investigational
studies of mice. Bob Welsh, a JLab/CWM jointly appointed professor, is one researcher working on the project. The research demonstrates that scientists can learn about how the body uses certain substances of interest - such as insulin, the fat-regula...
Phase III clinical program evaluates lubiprostone
...these trials begins this month. Lubiprostone is an investigational
compound currently being evaluated by the FDA for the treatment of chronic idiopathic constipation and associated pain and bloating in adults. The IBS-C clinical development program will include two phase III trials. Each trial will examine more th...
Columbia University researchers create mouse model that develops a human-like lymphoma
...had no way to test, with reliable accuracy, how an investigational
therapy would work in humans with this disease. Also, this lack of animal models has slowed understanding of the BCL6 gene and its precise role in tumor development. Published in the May 2005 issue of Cancer Cell, the study was led by Riccardo Dalla...
Data confirm panitumumab single-agent antitumor activity in patients with mCRC
...-developed by Amgen and Abgenix, panitumumab is an investigational
product in a novel class of targeted cancer treatments called epidermal growth factor receptor (EGFr) inhibitors. Panitumumab (formerly ABX-EGF) is the first fully human monoclonal antibody directed against EGFr and is being evaluated as both a mono...
Pall systems play key role in landmark NIH study on cord blood
...dest and largest public cord blood bank. Under an investigational
protocol and IND filed with the U.S. Food and Drug Administration, NYBC makes cord blood available to physicians treating children and adults faced with a life-threatening illness who need a stem cell transplant from an unrelated donor. Pall's sets ...
Sitagliptin, a new investigational treatment for type 2 diabetes, may offer new hope for patients
...two Phase II studies indicate that sitagliptin, an investigational
diabetes drug, appears to control blood sugar with...0 patients, ''sitagliptin'', Merck Sharp & Dohme's investigational
medicine from a new class of diabetes treatments called dipeptidyl peptidase 4 (DPP-4) inhibitors, i...
Cyberkinetics, Case to develop system to help restore extremity function
...ry brain-computer interface (BCI). BrainGate is an investigational
device currently in pilot clinical trials that consists of an internal sensor to detect brain cell activity and external processors that convert these brain signals into a computer-mediated output under the person's own control. The sensor is a tiny ...
Gene expression profile helps predict chemotherapy response in ovarian cancer patients
...econd-look surgery is currently the most sensitive investigational
approach for detecting residual disease in patients with advanced ovarian cancer who have achieved a complete clinical remission following chemotherapy, explains Cannistra.) The expression of 93 genes, collectively referred to as the Chemotherapy Res...
Interim long-term follow-up data show AMG 531 increases platelets in patients with ITP
...t long-term administration (up to 48 weeks) of its investigational
therapy AMG 531 was generally well-tolerated and stimulated platelet production in patients with immune thrombocytopenic purpura (ITP). Overall, 85 percent of patients in the study (29 of 34) achieved a platelet response, defined as doubling of the ...
Society of Nuclear Medicine commends FDA for release of new guidance documents
...day's release of two important documents regarding investigational
new drugs. "Guidance for Industry and Reviewers:...Phase 1 Studies" will facilitate the production of investigational
drugs for use in phase 1 studies, with the primary focus again on human safety. "These guidance docu...
'Bird flu' infections in humans prompt new investigation at Saint Louis University
...is plan, Saint Louis University will be testing an investigational
vaccine in children ages 2 to 9, a population that...son. In this study, researchers are evaluating the investigational
vaccine's safety and ability to stimulate antibodies, part of the body's proteins that fight infecti...
BiovaxID yields 89 percent survival in patients with aggressive non-Hodgkins
... and 20% chance of surviving 5 years. BiovaxID, an investigational
personalized anti-cancer vaccine, stimulates the immune system to seek out and destroy tumor cells. The data were published in a recent edition of Nature Medicine (Nat Med.2005; 11(9):986-91). In this single-arm, open-label Phase 2 clinical study, ...
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