Secrets of the sea yield stronger artificial bone
...ntly used in synthetic bone. Although still in the investigational stages, variations of this substance could also be used in a myriad of applications in which strength and lightness are imperative, such as dental implants, airplane manufacturing and computer hardware. As reported in the January 27, 2006 edition of ...Experimental TB drug effective against resistant and latent mycobacterium tuberculosis
... pharmacology and toxicology in preparation for an investigational new drug (IND) application to the Food and Drug Administration, which they hope to submit in a few months, so they may proceed to clinical trials. If the drug lives up to the promise in human trials that it showed in the laboratory, it could be av...Investigational therapy denosumab increased bone mineral density with twice-yearly dosing
...clast (cells that break down bone) activity. This investigational therapy is the first RANK Ligand inhibitor in late stage development. Amgen is studying denosumab for its potential in a broad range of conditions associated with bone destruction including osteoporosis, treatment-induced bone loss, bone metastases...Providence health system shows investigational osteoporosis therapy increases bone mineral density
... Health System researchers announced today that an investigational therapy for bone loss, denosumab, demonstrated sig...ment by Amgen, Inc. of Thousand Oaks, Calif. The investigational therapy is designed to target RANK Ligand, a protein that is the primary mediator of osteoclast form...Duke to test bird flu vaccine dosing
...icenter trial that will test a modified form of an investigational bird flu vaccine to determine whether the vaccine still triggers a strong immune response at lower doses. The seven-month trial is sponsored by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health. Also part...Appetite-inducing hormone receptor found active in breast cancer
... synthesis. "This finding gives us a promising new investigational target in the fight against breast cancer," the authors report. "If we can find a way to selectively activate the Y1 receptor, we can limit breast cancer growth in the body." Further studies of the Y1 receptor's role, they explain, may ultimately le...Tramiprosate (Alzhemed) preclinical results published in Neurobiology of Aging
... new class of therapeutic agent and is Neurochem's investigational product candidate for the treatment of Alzheimer's disease (AD). The results presented in this paper include the amyloid binding and neuroprotective characteristics of tramiprosate (Alzhemed) and provide evidence for the potential disease-modifying e...Tumor response may not be best measure of efficacy in non-small cell lung cancer treatment
...ents who have a partial or complete response to an investigational treatment plus those whose disease stabilizes. "In the past, we have used the complete response rate plus the partial response rate, or CR + PR, as our sole efficacy measure," Lara said. "The disease control rate, DCR, is the complete response rate p...Gardenia fruit compound starting point for diabetes therapy
...ell added. "Genipin represents an extremely useful investigational tool for studying a number of aspects of UCP2 biology," Lowell added. UCP2 plays a role in the process by which food is converted into energy storage molecules by cellular powerhouses called mitochondria in cells throughout the body....$14.6 million NIH Grant will build on macular degeneration findings
... of approaching this challenge from many different investigational angles. I'm enthusiastically looking forward to working with my co-investigators, all of who share the overall dream of ultimately developing therapies for AMD," he added. The investigation includes efforts to determine whether other genes are asso...Combating anthrax: Results of study published this month as researchers look for a better vaccine
...We were able to demonstrate in this study that the investigational anthrax vaccine produced an immune response that j...s vaccine in the future." Gorse indicated that the investigational vaccine, made by VaxGen Inc., demonstrated a clear relationship between the amount of vaccine admini...Acorda announces positive Phase 3 Fampridine-SR study in people with multiple sclerosis
...R is a sustained-release tablet formulation of the investigational drug fampridine (4-aminopyridine, or 4-AP). Data collected in laboratory studies found that fampridine can improve the communication between damaged nerves, which may result in increased neurological function. Fampridine-SR Mechanism of Action ...FUZEON with investigational HIV drug results in remarkable number of patients achieving undetectable
...initiate therapy with FUZEON (enfuvirtide) and the investigational integrase inhibitor MK-0518 can achieve undetectable levels of HIV (less than 400 copies per mL of blood)1. Such response rates have never been achieved in clinical trials of HIV patients living with drug-resistant virus. This significant antiviral...New biologic treatment for tennis elbow may replace surgery for chronic sufferers
... faciitis. Treatment with PRP is still considered investigational and further research is needed before it can be made available to the general population. "The body has an extraordinary ability to heal itself," says Mishra. "All we did was speed the process by taking blood from a different area, concentrating it...U of MN Center for Drug Design awarded $2.5 million grant
... lead to filing an application with the FDA for an investigational new drug (IND)....Study finds periodontal treatment does not lower preterm birth risk
...le in preterm birth, we want to cast a wide enough investigational net to determine which women are at risk." Atkinson said the 1,800-patient MOTOR study is designed a little differently than OPT. It involves a broader socio-economic cross section of women, provides fewer basic dental services, and includes wome...Eculizumab is well-tolerated and shows significant improvement in PNH patients (Ph III)
...r 9, 2006 Eculizumab, a novel monoclonal antibody investigational drug developed by Alexion Pharmaceuticals, Inc. (N...e initiation of an Expanded Access Program for the investigational agent eculizumab in the United States for patients with paroxysmal nocturnal hemoglobinuria (PNH), i...New test predicts blood cancer's sensitivity to experimental cancer drug
...self-destruct signals at bay. They showed that the investigational drug neutralizes the Bcl-2 action, unleashing mole...e. Letai said that his group has tested Abbott's investigational compound ABT-737 against cultured CLL cells with striking results. "We've treated CLL samples from s...Biogen Idec acquires Brandeis spin-out
...isease management. Syntonix is expected to file an investigational new drug application with the Food and Drug Administration for FIX:Fc in 2007. The transaction closed on Januray 31, 2007. In connection with the closing of the merger, Syntonix became a wholly owned subsidiary of Biogen Idec. Biogen Idec plans to m...Adult stem cells to repair hearts damaged by severe coronary artery disease investigated
...lect the subjects CD34+ stem cells for use in this investigational therapy. Schaer then uses a catheter-based, non-... cell delivery. The researchers then use a special investigational catheter that functions like a "global positioning system" to precisely deliver CD34+ cells, or plac...