Leading drug discovery and biotechnology scientists and experts discuss latest advancements
...a decline in innovation and in the success rate of investigational drugs. Dr. Butcher describes a broadly applicable approach to evaluating lead compounds and drugs, using panels of human disease models in which primary human cells of multiple types are cultured in complex conditions to mimic disease biology. The ...Advances in personalized medicine on agenda for 54th Society of Nucelar Medicine Annual Meeting
...d Drug Administration will address the role of the investigational new drug (IND) in clinical research; they will provide a Radioactive Drug Research Committee update on June 5 and present updates on PET regulations on June 7. Additionally, representatives from the Nuclear Regulatory Commission will address "Running...Investigational cancer drug targets critical proteins
...called acetylation, confers a strong attraction to investigational drug 17-AAG, says Dr. Yonghua Yang, postdoctoral fellow in molecular oncology in the laboratory of Dr. Kapil Bhalla, director of the Medical College of Georgia Cancer Center. "17-AAG blocks the activity of hsp90, which normally binds with ATP, an e...Smallpox outbreak: How long would it take for vaccines to protect people? Would it work?
...nt Louis University will look at the ability of an investigational vaccine made by Bavarian Nordic to stimulate the i...y said this research compares the ability of a new investigational smallpox vaccine called IMVAMUNE to produce a strong immune response against smallpox disease with a...Scientists identify new strategy for preventing acute and chronic brain disease
...here is still no effective way to prevent it. Many investigational therapies for AD aim to reduce levels of amyloid-beta proteins (AB) because Amyloid-beta builds up to abnormally high levels in the brains of people with AD and is widely suspected to cause the disease. "We wanted to pursue a complementary strategy...Stem cells may look malignant, not act it
...s and could make a difference as to whether or not investigational drugs we're testing work or don't work," he said. "The significance of this is new treatments may work in the culture dish but may not translate to the clinic or the hospital room, and for many reasons. One of the reasons could be bone marrow contami...SNM recognizes R. Edward Coleman with 2007 Georg Charles de Hevesy Nuclear Pioneer Award
...ch as Food and Drug Administrationapproved agents, investigational new drug agents (monoclonal antibodies for diagnosis and therapy, I-131 MIBG for therapy of neuroendocrine tumors), Radioactive Drug Research Committeeapproved agents (0-15 water for tumor blood flow, F-18 labeled agents for PET imaging of tumors, et...Michael R. Zalutsky receives SNM's 2007 Paul C. Aebersold Award
... assists the centers members in the preparation of investigational new drug applications to the Food and Drug Administration to permit clinical investigation of promising novel radiolabeled molecules of potential utility for cancer diagnosis and treatment. In addition, Zalutsky has been an adjunct associate profes...New genetic test developed at Emory advances detection and diagnosis of muscular dystrophy
...edition of the journal Nature show that PTC124, an investigational new drug designed to bypass dystrophin nonsense mutations and restore a functional protein, was effective in a preclinical (animal) model of Duchenne muscular dystrophy (DMD). (www.clinicaltrials.gov). ...Study begins to reveal clues to the cause and progression of sepsis
...e years, little is known about the condition. Past investigational treatments have been based on data from small studies, and most of these therapies have failed. Researchers at the University of Pittsburgh believe that these treatments failed, at least in part, because of insufficient data to fully understand th...