Mayo Clinic awarded major NIH contract for smallpox genomics research
...ta points in this type of genomic research -- will involve Mayo biostatisticians and the Mayo Advanced Genomics Technology Center (AGTC). "This award to Dr. Poland is another tangible confirmation that Mayo is fast becoming a leader in applying the tools of Genomics to the most pressing issues in the pre...Protein energy profiles offer clues about amyloids
...and heart disease. "We know now that most diseases involve proteins going wrong in one of two ways," said lead researcher Cecilia Clementi, assistant professor of chemistry at Rice University. "In the first, proteins don't function correctly because they fold into the wrong shape. This is something we see in...September/October 2004 Annals of Family Medicine tip sheet
...er on Bill Visits to family physicians frequently involve the concurrent care of multiple problems that billing data do not adequately reflect. Analyzing physician logs from 572 patient encounters, researchers found that physicians report managing an average of 3.05 problems per encounter but record only 2....Forum at Virginia Tech to address issues of human cloning
...ic human cloning is with us. Both types of cloning involve complex social and ethical dimensions that merit public discussion," says Choices and Challenges co-director Eileen Crist of the Department of Science and Technology in Society. The forum is designed both to inform and to provide an opportunity for p...UCR researchers identify key plant enzyme that defends against multiple infections
...the Sept. 23, online issue of Current Biology, and involve research on the key plant protein, vacuolar processing enzyme or VPEg, in Arabidopsis thaliana, or thale cress, that is required for this process. Programmed cell death (PCD), which occurs naturally in all multi-cellular organisms, is the regulated e...UF scientists have bionanotechnology recipe to find elusive bacteria
...ent by traditional means could take days and would involve sealing off the entire area during that time, he said. "Instead, we can come back in 20 minutes and say either this is safe or there is a problem." Chad Mirkin, professor of chemistry at Northwestern University and director of Northwestern's Institut...Muscling in on a deadly cancer
... fibers normally do not. Also, a number of cancers involve stem cells. So "it's a big deal for a [mature or nearly mature muscle] cell not be proliferating and then all of a sudden to be able to proliferate" to form tumors, Capecchi adds. Keller says other researchers previously found th...First-ever Texan/German symposium opens doors
...e joint research program with the MPI-P that would involve new research directions in polymer materials, future grant submissions and perhaps a joint doctoral program," Advincula said. "Knoll's group is very strong in macromolecular assemblies and biophysics, and we hope to gain more interaction in this are...Brain differences in adolescents, psychopaths, lend to their impulsive, risk-taking behavior
... presenting participants with various choices that involve "gambling" a certain number of points based on the likelihood that their choice will be correct. Participants can make two choices: choices that are less likely to be correct, but result in a greater number of points earned if they are correct or a g...Early life stress harms mental function and immune system in later years
... In the rat, maternal effects on stress responses involve stable, postnatal alterations in chromatin structure such as DNA methylation. "Early experience can actually modify protein-DNA interactions that regulate gene expression," Meaney says. "The effects of mother-infant interaction on chromatin structure...Genetically endowed worm may substitute for rodents in some toxicology testing
...during the expensive initial stages that typically involve large-scale screening. For example, it takes just 3 days for the roundworm to develop from egg to adult. Since each adult worm is only 1 millimeter in length, large numbers can be maintained and tested in small spaces. Because the round...Rice biologists elected AAAS Fellows
... evolution of social interactions in contexts that involve cooperation, conflict, or both. He has studied wasps and stingless bees to determine the benefits of sociality, the role of genetic relatedness and the extent of conflicts within social insect societies. Recently, he has turned his focus to the socia...Stress impairs thinking via mania-linked enzyme
...d patients. Susceptibility to bipolar disorder may involve variants of genes that code for a key PKC precursor and for a stress-sensitive signaling protein that normally puts the brakes on PKC activity. The new study shows how PKC triggers cognitive symptoms in response to stress. When the stress-sensitive m...Diabetes drug works by enhancing fat cell energy production
...uch as rosiglitazone, work through mechanisms that involve fat. Cell culture work has indicated that rosiglitazone alters the mitochondria of fat cells, both in their structural features and in the types of proteins they produce. Mitochondria are what make the cell's energy. Silvia Corvera and colleagues, f...JCI table of contents November 1, 2004
...uch as rosiglitazone, work through mechanisms that involve fat. Cell culture work has indicated that rosiglitazone alters the mitochondria of fat cells, both in their structural features and in the types of proteins they produce. Mitochondria are what make the cell's energy. Silvia Corvera and colleagues, f...Research team discovers possible genetic mechanism behind congenital heart defects
...births in Canada. The next steps for this research involve examining patients with congenital heart defects to see if they, like the mouse model, have this modified protein. Other members of the research team include the study's co-lead authors Dr. Heiko Lickert of the Samuel Lunenfeld Research Institute at ...Tiny exosomes extracted from donor cells may be 'magic bullet' for drug-free transplants
...nhancing qualities, several approaches under study involve giving recipients donor dendritic cells that have been modified in some way. The idea is that the modified donor cells would convince recipient cells that a transplanted organ from the same donor is not foreign. "What may be a more effective approac...Rethinking new therapies for Crohn's disease at U.Va.
...fective treatment strategy for such patients might involve the blockade of multiple cytokines in order to intervene in several pathways," he concludes....Illegal tuna fishing and farming leads to demise of species
...ting rules. This new method WWF is proposing would involve real time monitoring of all catches by a centralized ICCAT body," said Guglielmi. Real time reporting follows the transfer of live fish, where the catch size is accurately assessed using video recording and acoustic methods, or immediately after the ......efs and more limited damage. Other scenarios could involve the difference between the disintegration or the stability of major ice sheets in Antarctica or Greenland, which would dramatically affect sea level. The researchers reported their findings in a paper to be published in the Proceedings of the Nationa...