UCSD medical researchers use brain cell transplants to correct muscle spasms after aneurysm surgery
...s corrected involuntary muscle spasms in rats with ischemic spinal cord injury, according to research publishe...leaves the heart. A subpopulation of patients with ischemic spinal cord injury develop a prominent muscle spasticity, or jerkiness of the legs and lower body, d...Elevated inflammatory enzyme, Lp-PLA2, significantly linked to ischemic stroke
...cally significant doubling of risk of suffering an ischemic stroke over a period of about six years compared to those with the lowest levels of the enzyme after taking age, gender and race into consideration (p <0.001). Even when traditional cardiovascular risk factors such as systolic blood pressure, sm...Heart responds to fasting by remodeling vital energy-producing components
...l explanation to a pattern discerned in studies of ischemic heart patients, who have restricted blood flow to ...sting to note that the majority of sudden death in ischemic heart patients occurs in the early morning hours when people have typically had a long fast and are ...JCI table of contents, 3 January 2005
...t. TITLE: Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors. AUTHOR CONTACT:Peter Carmeliet Center for Transgene Technology and Gene Therapy, Leuven, Belgium. Phone: 32-16-34-57-72; Fax: 32-16-34-59-90; E-mail: peter.carmeliet@med.kul...Bioartificial kidney under study at MCG
... Szerlip explains. As examples, kidneys can become ischemic and begin to fail if blood pressure drops because of a long surgery with significant blood loss. Infection can further reduce blood flow to the kidneys. Ironically, some antibiotics patients need for these infections also can harm the kidneys. Even t...UT Southwestern researchers see hope for treating blindness in preemies
...t oxygen radicals, the levels of which are high in ischemic tissues such as in the eyes of mice lacking HIF-2a, Dr. Garcia said. "The ability of HIF-2a to control multiple essential genes may be required for proper eye development," he said. "Furthermore, there may be additional, and as of yet unidentified,...JCI table of contents March 1, 2005
...g recovery of the blood flow and vessel density in ischemic limbs. BDNF has local effects on TrkB expressing cells and also recruits a subset of blood stem cells that contribute to neo-angiogenesis. This special population of cells responds specifically to BDNF and contributes to neovascularization. In an a...Boosting blood vessels with BDNF
...g recovery of the blood flow and vessel density in ischemic limbs. BDNF has local effects on TrkB expressing cells and also recruits a subset of blood stem cells that contribute to neo-angiogenesis. This special population of cells responds specifically to BDNF and contributes to neovascularization. In an a...Aspirin is safer than warfarin and just as effective for treating blocked arteries in the brain
...ut 10 percent of the 900,000 strokes and transient ischemic attacks (TIAs) in the United States each year. TI... about 22 percent of the patients had a subsequent ischemic stroke (caused by blockage of an artery), brain hemorrhage, or death from other blood vessel-related...Ingredient in garlic protects against severe chronic pulmonary hypertension in rats
...n humans could help lower blood pressure, decrease ischemic injury, reduce serum cholesterol, inhibit platelet function and enhance thrombolysis. Garlic also has been suggested to improve arterial oxygenation associated with pulmonary dysfunction in patients with hepatopulmonary syndrome. However, obtaining c...Antioxidant-rich diets reduce brain damage from stroke in rats
...reated) group ate chow only. After four weeks, an ischemic stroke with reperfusion was induced in the rats. An ischemic stroke occurs when a blood clot cuts off the oxygen supply to the brain like the kink in a hose cuts...Chemical that triggers hibernation may protect muscles
A phenomenon known as ischemic preconditioning (IP), in which blood flow to muscle is reduced and then restored, has previously been shown to increase muscle function, especially in the heart. A new study published online June 6, 2005 in Muscle & Nerve explores the link between th...Does gene therapy work? Nuclear medicine may provide the answers
...ngiogenic inducer protein--in rabbits submitted to ischemic limb disease. However, no data have been available...erapeutic candidate for treating severe myocardial ischemic disease," he added. The French scientists examined Cyr61's effect in a porcine model of ischemic hea...SPECT imaging can evaluate stem cell therapy effectiveness in patients with coronary heart disease
...aluate the effectiveness of stem cell therapy with ischemic or coronary heart disease. The group's findings fr... cell therapy will be widely used in patients with ischemic heart disease," said Lee. "Gated myocardial SPECT will help evaluate treatment effect and suggest th...Pomegranate juice for moms may help babies resist brain injury
...babies born before 34 weeks of gestation. Hypoxic ischemic brain injury can lead to seizures, a degenerative condition known as hypoxic ischemic encephalopathy, and mobility impairments including cerebral palsy. When scientists temporarily lowe...JCI table of contents July 1, 2005
...tubular epithelial cells during repair of the post ischemic kidney is independent of bone marrow stem cells AUTHOR CONTACT: Jeremy Duffield Harvard Institutes of Medicine, Boston, MA USA Phone: 617-525-5914; Fax: 617-525-5830; E-mail: jduffield@rics.bwh.harvard.edu View the PDF of this article at: https://...JCI Table of contents August 1, 2005
...LE 3: Akt1/Protein Kinase B alpha is critical for ischemic and VEGF-mediated angiogenesis AUTHOR CONTACT 3: William Sessa Yale University School of Medicine, New Haven, CT USA Phone: 203-737-2291; E-mail: william.sessa@yale.edu View the PDF of this article at: https://www.the-jci.org/article.php?id=247...Stem cells bring fast direct improvement, without differentiation, in acute renal failure
...dministered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-indepe...mon and the most treatment-resistant type of human ischemic ARF." Next steps Current studies are investigating the collective and individual renoprotective...Studies find possible drug targets for improving vascular health
...h factor (VEGF) requires Akt1. VEGF is produced by ischemic tissue, as well as tumor cells, to stimulate the formation of new blood vessels. The data also suggest that inhibition of Akt1 signaling may be an effective strategy to block not only tumor growth, but the pathological growth of new blood vessels fro...... pathogenesis of many inflammatory, autoimmune and ischemic diseases are due to inappropriate activation of the complement system - proteins found in blood that help destroy bacteria and other foreign cells. Complement inhibitors are now used therapeutically but there are unresolved questions regarding their...