Tag: "ischemic" at biology news
JCI table of contents October 1, 2005
...ory and detrimental role in the kidney after renal ischemic
injury in vivo. This data gives new insight into the way the kidney functions in the absence of infection, and unravels the mechanism by which an inappropriate and subsequent detrimental inflammatory response in the kidney is induced. This study bro...
NHLBI funds new centers for cell-based therapy
...eart and to reverse heart failure in patients with ischemic
heart disease. The team will initially study the use of bone-marrow derived mesenchymal stem cells as a treatment for ischemia (reduced blood flow to the heart). Mesenchymal stem cells have the potential to develop into mature cells that produce fa...
Hope for arthritis, heart attack, stroke relief found in unique 'acid active' receptor
...g the development of arthritis and other systemic, ischemic
and inflammatory processes." "An important qu...physiological conditions, or more particularly, in ischemic
and inflammatory conditions where destructive and reperfusion processes regularly occur, for example...
JCI table of contents: December 2005
... Cincinnati define the early pathways activated by ischemic
injury. The authors find that a protein called thr...ionally, mice lacking TSP-1 were protected against ischemic
injuryinduced renal failure and tubular damage. Thus, TSP-1 is a novel mediator of ischemic
Molecular cabal contributes to stroke damage
...lcium permeable] ASICs have now been implicated in ischemic
neuronal damage. "Our findingsheds new light on the development of therapeutic agents against excitotoxic and acidotoxic neuronal damage," concluded the researchers. Also, they added, since such NMDARs and ASIC1a are involved in seizures and pain sen...
New 'molecular switch' protein protects the heart from major cardiovascular damage
...ve into their 80s or 90s, so there's more time for ischemic
heart disease and heart failure to develop." In a series of experiments, U-M researchers studied the effects of the histidine substitution in troponin I on 1) transgenic mice with the modified form of the protein and normal littermates without the mo...
VCU study shows Levitra may protect the heart
... protect the brain, liver and other organs against ischemic
injury those injuries that are caused by lack of oxygen. Kukreja and his colleagues began studying sildenafil in 2002 as part of ongoing research into "preconditioning," a way to protect the heart muscle from serious damage in the future by subject...
New route to stroke therapy could protect vulnerable neurons
...n vulnerable neurons, they could protect them from ischemic
injury. Conversely, by switching it off in injury-...ons, they could render those neurons vulnerable to ischemic
damage. They also traced the injury pathway further upstream, finding that an "executive" enzyme cal...
Joslin study provides physiological evidence that insulin is critical for blood vessel formation
...the disease. Similarly, patients with diabetes and ischemic
(reduced blood flow) heart disease have a much higher mortality rate than the general population. Now, a team of researchers at Joslin Diabetes Center led by George L. King, M.D., Director of Research and Head of Vascular Cell Biology, and Zhiheng H...
Adaptation to oxygen deprivation elucidates tumor physiology
...dy tissues--as can occur in the exercising muscle, ischemic
hearts, or tumors--hypoxia results, the researchers explained. Cells adapt to low oxygen conditions by activating a "program of gene-expression changes" initiated by so-called hypoxia-inducible factor-1 (HIF-1) transcription factor. "Over a century a...
Fine particles increase hospital admissions for heart failure and cardiovascular disease
...rebrovascular events, peripheral vascular disease, ischemic
heart disease, chronic obstructive pulmonary disea...tudy participants also experienced higher risks of ischemic
heart disease, heart rhythm disturbances, heart failure and chronic obstructive pulmonary disease as...
Immunoblot agent misses altered heart cell kinase, points to possible therapeutic opening
...in the regulation of cardiac contractile function, ischemic
preconditioning, and structural remodeling of the heart. "Our recent studies have focused on PKC-delta regulation through phosphorylation events on serine/threonine and tyrosine residues in various domains of the protein. The results suggest that t...
Electrical stimulation boosts stroke recovery
...part of the brain controlling motor function helps ischemic
stroke survivors regain partial use of a weakened ...s on people age 21 years and older who have had an ischemic
stroke at least four months prior to screening and suffered weakness in one hand or arm. Stroke pat...
Possible brain hormone may unlock mystery of hibernation
...a treatment that is effective for preventing brain ischemic
damage." In cryosurgery, physicians use extreme cold to destroy abnormal tissue, such as cancerous tumors....
Economic benefit of NINDS-supported clinical trials estimated at more than $15 billion
...a trial of tissue plasminogen activator (t-PA) for ischemic
stroke that showed that t-PA could prevent brain damage if used within the first three hours after a stroke begins. Another was the Randomized Indomethacin Germinal Matrix/Intraventricular Hemorrhage Prevention Trial, which showed that using indomet...
New compound reduces stroke damage
... and the most common cause of adult disability. An ischemic
stroke occurs when a cerebral vessel occludes, obstructing blood flow to a portion of the brain. Currently, there is only one approved stroke therapy, tissue plasminogen activator, which targets the thrombus within the blood vessel. Because of the l...
Newly discovered protein could hold key to preventing heart disease
...d that MCPIP is elevated in human hearts suffering ischemic
heart failure. MCPIP is formed when an often-studied protein called MCP-1 binds to receptors. The MCP-1 protein helps to attract white blood cells known as monocytes to infected and injured areas of the body. The monocytes then attack bacteria and he...
Novel non-invasive imaging technology may allow precise diagnosis of coronary artery disease
...e cardiac imaging technology for the assessment of ischemic
heart disease--also known as coronary artery or co..., and as many as 3 to 4 million Americans may have ischemic
episodes without knowing it. Myocardial perfusion (blood flow) imaging using single photon emission...
Growth factor triggers growth of new blood vessels in the heart
...ide substantial benefit to patients suffering from ischemic
heart disease and myocardial infarctions and offer an alternative to invasive procedures like surgery or angioplasty. About 12 percent of heart patients are not eligible for bypass surgery, which redirects blood around clogged arteries, or for other...
New tool tracks brain development in babies
...a result of complications during delivery. Hypoxic ischemic
injury can result in severe motor problems. "The pattern and extent of the brain injury largely determine the neurological and developmental consequences for the newborn," Dr. van Pul said. "The detection of injury at an early stage is essential for ...
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