Identifying the mechanism behind a genetic susceptibility to type 2 diabetes
... with increased expression of TCF7L2 in pancreatic islet cells and decreased islet cell secretion of insulin. Consistent with this, ectopic overexpression of TCF7L2 in human islet cel...JCI table of contents: August 1, 2007
... with increased expression of TCF7L2 in pancreatic islet cells and decreased islet cell secretion of insulin. Consistent with this, ectopic overexpression of TCF7L2 in human islet cel...Gene discovered for type 1 diabetes in children
...lls in such a way that they attack and destroy the islet cells in the pancreas, resulting in type 1 diabetes. A particular version of the gene protects against this inappropriate autoimmune response, while a different version of the gene makes it more likely to happen. Although much research remains to ...JCI Table of Contents -- July 2, 2007
... autoimmunity" The authors found that transplanted islet cells, but not bone marrow cells, expressing nativ...ffector dependence on insulin B:923 peptide in NOD islet autoimmunity AUTHOR CONTACT: George S. Eisenbarth University of Colorado Health Sciences Cente...JCI table of contents: June 21, 2007
...l pathway for the expansion of recently identified islet (Isl-1)positive cardiac progenitor cells. These cells help form the right ventricle and outflow tract of the developing heart. The authors show that Wnt signaling through activation of fibroblast growth factor 10 (FGF10) expression was required for e...UCLA researchers reprogram normal tissue cells into embryonic stem cells
...be prodded into becoming various cells types beta islet cells to treat diabetes, hematopoetic cells to create a new blood supply for a leukemia patient, motor neuron cells to treat Parkinsons disease. If we can recreate this in human cells, it has significant implications for regenerative therapies, sa...Scientists honored with 'Excellence in Clinical Research Award'
...ng the use of growth factor peptides to regenerate islet cells leading to the development of and clinical trials for new compounds to induce beta cell regeneration. A JDRF-funded researcher for many years, Dr. Rabinovitch has received many awards and served on many professional committees and offices, incl...A close-up on pancreatic disease: How do we improve the odds?
...sms (IPMN), one cystic papillary tumor, one cystic islet cell tumor] and 31 were malignant (14 mucinous cystic adenocarcinomas, 17 invasive carcinomas in IPMN). Male gender seemed to predict malignancy (19/67, 28%) compared to females (12/99, 12%), as did older age (average 67 years for malignancy vs. 62...Decoding protein structures helps illuminate cause of diabetes
...linked to toxic clumps of the protein hIAPP (human islet amyloid polypeptide), which is normally produced by the same cells that make insulin. An unknown trigger prompts the protein to fold into sharp fibers that poke holes in pancreatic cells, killing them. Though scientists already have a good idea ...Adult stem/progenitor cells repair of damaged brain, pancreas, kidney cells newly understood
...lls normally found in the pancreas, producing more islet cells, thus increasing the mices production of insulin, and lowering blood sugar. With some tissue damage, the administered cells are able to do their repair activities in as little as a day and largely disappear. The scientists could still see ...Joslin study indicates insulin receptors play a critical role in promoting islet growth
...lin receptor as an important protein that promotes islet cell growth in mice whose bodies are unable to use... insulin secretion from the pancreas and grow more islet cells, also known as beta cells, harnessing this growth response could lead to new treatments for ty...JCI table of contents: April 2, 2007
...ic acinar cells contribute to acinar cell, but not islet beta cell, regeneration AUTHOR CONTACT: Doris A. Stoffers University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. Phone: (215) 573-5413; Fax: (215) 898-5408; E-mail: stoffers@mail.med.upenn.edu . Karen Kreeger Department of ...... such as particular types of neurons or pancreatic islet cells," she said....Joslin-led study uncovers role of appetite hormone MCH in insulin production
...immune process has destroyed the insulin-producing islet cells in the pancreas. In type 2 diabetes, the far...that MCH and its receptors are indeed expressed in islet cells of mice and humans. They then treated human donor or mouse pancreatic islet cells with MCH and...Cells passed from mother to child during pregnancy live on and make insulin
...ad, the researchers found a small number of female islet beta cells in male pancreatic tissue (procured from autopsies) that produced insulin. Microchimerism is the term used when an individual harbors cells or DNA that originate from another genetically distinct individual. "To our knowledge a maternal co...Research yields new insights into the cause of diabetes
...ion of insulin in the beta cells. But without the islet architecture, communication among the beta cells breaks down and the cells fail to respond to glucose by secreting insulin. Thus, PERK-deficiency both hampers cell-to-cell signaling of glucose levels and greatly diminishes insulin production at the ...JCI table of contents: December 1, 2006
...er autoimmune diseases. TITLE: Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP AUTHOR CONTACT: Thomas W. H. Kay St. Vincents Institute, Fitzroy, Victoria, Australia. Phone: +61-3-9288-2480; Fax: +61-3-9416-2676; E-mail: tkay@svi.edu.au . View the P...Replacing insulin is top-ranked breakthrough foreseen for health in developing world
...ovel methods of insulin replacement and pancreatic islet cell regeneration for diabetes." Many panellists noted the heavy health, social and economic burdens that result from widespread diabetes in developing countries. Controlling that disease would consequently reduce complications such as blindness,...Will stem cell-based treatments make a difference to the developing world?
...ovel methods of insulin replacement and pancreatic islet cell regeneration for diabetes. The panelists ran...row stem cell transplantation or microencapsulated islet cells using new biomaterials, could provide a permanent solution to treating diabetes and reduce the...Nanotechnology propels advances in regenerative medicine research
...icles hastened wound healing in rabbits and, after islet transplantation, cured diabetes in mice. Nanoparticles with other chemical compositions accelerate bone repair in rats and promote the growth of neurons in mice and rats with spinal cord injuries, he says. (COLL 218, Monday, Sept. 11, 3:50 p.m.) ...