A broken stress response system can contribute to Gleevec resistance
...ng upon the benefit that is offered by Gleevec and keeping CML under better control. CML is caused by a genetic change that scientists call the Philadelphia chromosome. It results when chromosomes 9 and 22 break and reattach themselves to one another. At the point where the chromosomes meet, the joined DNA ...Novel molecular 'signature' marks DNA of embryonic stem cells
...ersity. "This approach could be a key strategy for keeping crucial genes quiet, but primed for when they will be most needed." Although most people think of heredity in terms of DNA and the genes encoded by it, chromatin also carries inherited instructions known as "epigenetic" information. Thus, the chromat...Nice guys do finish first in lizards' evolutionary race, says MSU professor
...s. Blues beat yellows because theyre close to home keeping watch. Yellows beat orange because the bullies arent sticking close enough to home to keep an eye on things. Research has focused on why the blue throats are willing to cast aside their own opportunities to procreate for the benefit of a friend. Why ...Researchers find protein that silences genes
... been on the hunt for the proteins responsible for keeping the silenced genes off. In their current paper, published on-line on April 28, 2006, in Genes and Development, and the cover story for the print version of the journal due out May 15, Pikaard and his collaborators describe a systematic effort to exa...Weizmann Institute scientists discover a molecular security mechanism for keeping mutations in check
...ct as supervisors, taming the careless enzymes and keeping them in careful check. The scientists research sho...alance, allowing them to divide and multiply while keeping the mutation rate, and therefore the cancer risk, to a minimum....Robots manipulating animal behaviour
... on nanotechnology. Moreover, these systems are in keeping with emerging European research such as collective robotics and FET-funded projects such as Swarmbots. "We believe farming in Europe can only survive if is associated with high technology," he adds, pointing to a potential increase in competitiveness...Nanotechnology shows early promise to treat cardiovascular disease
..., called macrophages, perform an essential role in keeping organisms healthy, their interaction with highly oxidized LDL molecules has quite the opposite effect," he said. Mogue explains that macrophages accumulate large amounts of oxidized LDL and secrete chemicals that can damage the neighboring tissues an...Joslin-led study reveals new findings on insulin signaling in the liver
...imary chemical factory, and among its key roles is keeping glucose levels in the blood constant between meals. The liver also produces and packages cholesterol and triglycerides to send throughout the body. Insulin's activity in the liver controls both of these processes, but, until now, researchers have not...Bedsores and bald hides: Novel roles revealed for a 'scaffolding' protein
...ong thought to provide only mechanical support for keeping cells and tissues from literally falling apart turns out to have much wider utility. In a pair of reports, the protein K17 has been found to also influence wound healing and maintain the structural integrity of hair follicles, according to Johns Hopk......sible, more efficient, and in many cases faster by keeping all of the quantum bits active all the time, rathe...um computer have sought to harness this process by keeping qubits under strict control - only letting them communicate with each other occasionally. But such t...The results are in: Bacterial parasite strives for balance in host infection
...ating transmission-stage parasites, or spores. In keeping with the tradeoff hypothesis, the researchers predicted that the parasite should castrate early to optimize the appropriation of host resources, and produce intermediate levels of virulence to keep the host alive long enough to maximize spore product...HHMI awards $86.4 million for undergraduate science education
...ergraduate biology education is having a hard time keeping up. To address this challenge, the Howard Hughes Medical Institute (HHMI) is investing $86.4 million in bold and innovative science education programs at research universities across the country. HHMI -- the nation's largest private supporter of sci...Beaver dams create healthy downstream ecosystems
...m groundwater levels in the Colorado River valley, keeping soil water levels high and providing moisture to plants in the otherwise dry valley bottom. The results will be published 8 June in Water Resources Research, a journal of the American Geophysical Union. Cherie Westbrook of Colorado State University a......er cells are the body's immediate line of defense, keeping invaders in check until T and B cells of the immune system, which take a few days to mobilize, kick into full gear. Natural killer cells are armed with enzyme-filled sacs that spill their deadly contents when infected or cancerous cells cross the ki...HPV testing finds precancerous lesions at a higher rate than conventional pap smears
...t combination of tests increases sensitivity while keeping the number of false positives acceptable. Guglielmo Ronco, M.D., Ph.D., of CPO Piemonte in Torino, Italy, and colleagues set up a randomized controlled trial that screened over 33,000 women for cervical cancer, half with conventional pap smears and t...Next generation of science stars: 5 female scientists receive 2006 LOral USA fellowships
...eing honored by L'Oral USA this year -- are key to keeping the pipeline of women in science forthcoming."...Success comes at a cost, even for phages
...n demonstrated for a wide variety of organisms, in keeping with life history theory. In a new study published in the open-access journal PLoS Biology , Marianne De Paepe and Franois Taddei asked whether these trade-offs extend to viruses, which are not--by some definitions--even alive. Though not universal...Can you hear me now? Scientists find previously unknown receptors on adult stem cells
...y replacing cells that are damaged or killed while keeping us healthy. But investigators suspect that the system also can be detrimental in certaincircumstances -- for example, in leukemia patients that are vulnerable toinfections after receiving bone marrow or cord blood transplants or inautoimmune diseases...Septum keeps neurons in synch, can reduce epileptic seizures by 90 percent
...ain working within normal ranges," Colom said. "By keeping the neurons firing normally, the septum inhibits neuronal hyperexcitability, such as epilepsy, and hypoexcitablity, such as Alzheimer's disease." In addition, septal impulses may help to maintain the anatomical integrity of other brain structures. ...Chewing up a key regulator of fat synthesis keeps mice lean despite a high-fat diet
... and co-first author Ling Qi, Ph.D., reasoned that keeping the TRB3 pathway artificially "on" during both fasting and feeding might melt away fat depots. And that's exactly what happened. Mice genetically engineered to express permanently elevated levels of TRB3 protein in fat tissue were 10-20 percent skinn...