Mechanism discovered for muscle wasting seen in diabetes, AIDS and other diseases
...erial sepsis, AIDS, diabetes, and end-stage heart, kidney and obstructive pulmonary disease. Muscle wasting can cause generalized weakness and debilitation and in its extreme, when respiratory muscles are involved, asphyxia and even death. Dongsheng Cai, M.D., Ph.D., a postdoctoral Fellow at Joslin Diabe...Gene linked to greater risk of heart disease in type 2 diabetes
..., and are at increased risk for stroke, blindness, kidney disease and nerve damage. In a two-part study published in the Oct. 1 edition of the British journal Human Molecular Genetics, Dr. Doria and his colleagues at Joslin and other research centers in the Northeast and researchers in Italy focused on a g...Stony Brook University medical researcher developing new medication to prevent colon cancer
...side effects, including gastrointestinal bleeding, kidney damage, and allergic reactions ranging from mild to fatal. In addition, traditional aspirin is typically effective in preventing cancer in only about 50 per cent of those who take it. Colon cancer can take many years to develop, but it is frequent...Study at Joslin shows ease of introducing technology to kids with diabetes
...vent complications, such as blindness, stroke, and kidney disease, which are associated with prolonged high blood glucose levels. About the DAILY Study The four-week pilot study trial included 40 children and adolescents with type 1 diabetes who were receiving their care at Joslin Clinic in B...NIH funds rare childhood disease to provide insights into the origins of adult cancer
...palates and other skeletal defects, heart defects, kidney abnormalities and others. With treatment, many individuals with DBA live long, active lives, and some even experience prolonged remissions during which no treatment is required. More severe cases can be fatal. The research at SCH will help doct...Diabetic damage to eyes, heart, nerves, kidneys may be explained by controversial theory
...efforts to find new ways to reduce loss of vision, kidney failure, heart damage and other side effects of di...non-traumatic lower limb amputations, and diabetic kidney damage creates 43 percent of all cases of end-stage renal disease. Proponents of the theory argue...Joslin Diabetes Center awards 1st Mary K. Iacocca Faculty Fellowship
...ions, including heart attacks, strokes, blindness, kidney failure, blood vessel damage and nerve damage. The Iacocca Foundation was founded by Lee A. Iacocca in memory of his wife, Mary K. Iacocca. Over the past 20 years, the Iacocca family has contributed more than $6.5 million in grants to Joslin to fund...First human trial of bioartificial kidney shows promise for acute renal failure
...ch. -- The first test in humans of a bioartificial kidney offers hope of the device's potential to save the ...on humans, the results also suggest improvement in kidney function. The patients enrolled in the trial faced an average 86 percent likelihood of dying at the ...UNC Lineberger researchers identify molecular markers of aging
...e bone marrow, as well as organs such as the skin, kidney and liver. "As tissue stem cells age, they appear to express more p16INK4a and ARF, which would stop those cells from replenishing," Sharpless said. "As people age, they could just run out of functioning stem cells." Depletion of stem cells...Identifying the path to infection
...e of the infection, E. coli binds tightly to human kidney cells, using an 'adhesive protein' secreted by the cells through a membrane protein 'channel.' Our structure of this protein channel helps show how secretion occurs, which may eventually lead us to determine how to stop E. coli from attaching to the ...New program examines stem cells' potential to repair, replace damaged tissue
... there is potential here - when a patient needs a kidney transplant or when you have a patient with burns who needs skin grafts - the possibilities are endless," he says. Dr. Karl H. Wenger, a biomedical engineering scientist who is director of research for the MCG Department of Orthopaedic Surgery, will d...UCSD researchers find effective treatment for unusual fever syndrom caused by cold exposure
...scles and rash. In severe cases, patients develop kidney failure related to the disorder. A typical...fered from the severe form of FCAS that had caused kidney failure in several generations of her family. Since she began injections of anakinra every other da...New tool highlights activity of key cellular signal
...ulating cyclic AMP production in a human embryonic kidney cell line containing the targeted fluorescent Epac proteins caused an immediate build-up of cyclic AMP and activation of Epac at the cell membrane, where cyclic AMP is produced, the researchers report. Within seconds, build-up of cyclic AMP also bega...New gene therapy promising for treating Fabry disease
...causing constriction. Eventually, cardiac disease, kidney disease or strokes result. "Patients with Fabry disease either don't make enough of the enzyme alpha-galactosidase A or improper synthesis means the enzyme isn't active enough," says Jeffrey Medin, a U of T associate professor in the Department of M...JCI table of contents, November 15 2004
...********************* New structure described for kidney filter: the slit diaphragm One of the main functions of the kidney is the formation of urine by filtration of the plasma. The size-selective kidney filter, known as th...Safety of bismuth bullets questioned: Study
...ve bismuth exposure may be linked to blood, liver, kidney and neural problems. Gough says that populations who rely on potentially contaminated food sources, such as First Nations people, may be at greatest risk. ......d free of any evident developmental defects in the kidney or nervous system. They found no trace of GFR1 mRNA in non-Ret-expressing cells in these mice (which they named Cis-only mice, for their lack of trans signaling), while GFR1 transcripts were detected as expected in RET-positive cells, proving that th...Diamonds are a urologist's best friend
...ine can be discharged without obstruction from the kidney to the bladder,' Dr. Laube explains. The stents sometimes stay in the body for weeks or even months. Some patients have to use these ureter splints all their lives. If crystalline deposits develop, this can lead to life-threatening consequences. Dia...Antipsychotic drugs stop fatal viral infection in brain cells
...mericans with suppressed immune systems, including kidney transplant recipients, cancer patients undergoing chemotherapy and an estimated 4 percent of people with AIDS. PML is caused by the JC virus, which destroys the cells that produce the fatty sheath that covers nerve cells. This causes dementia, vision...Menssana research at NJIT receives kudos for FDA-approved breath test
...ath smells fruity because of acetones, patients in kidney failure have breath that smells like urine, and liver disease and lung infections also have distinctive odors." But Phillips' research has taken breath analysis way beyond the sniff test. In February 2004, the federal Food and Drug Administration ap...