JCI table of contents March 1, 2005
...und found in licorice, glycyrrhizic acid (GA), can kill cells that are latently infected with KSHV. GA induces cell death by altering levels of proteins involved in latency like LANA and v-cyclin. The possibility that GA-like compounds might be useful in treating clinical KSHV infections is of considerabl...NHGRI targets 12 more organisms for genome sequencing
...model for parasitoids, which lay their eggs on and kill arthropods, thus controlling pest populations. In the United States, the use of parasitoid wasps in agriculture as a biological control of crop damaging insects saves approximately $20 billion annually. The wasp will serve as a good comparison for t...'Grubby' research promises environmental/economic benefits
...for fly control aren't very effective." "They also kill biological beneficials that feed on house fly larvae," he said."for instance, parasitic wasps, mites and predatory beetles."Tomberlin believes these measurement problems could be eliminated with an expanded study. "This was first-year preliminary dat...Research may provide ways to inhibit cancer's ability to resist treatments
...s such as ionizing radiation or certain drugs that kill cells by damaging their DNA. DNA, or deoxyribonucleic acid, is a large molecule shaped like a double helix found primarily in the chromosomes of the cell nucleus and contains the genetic information of the cell. Once damaged, cells have developed bio...Stealth worms may improve insect pest control
...s with bacteria in its intestine that specifically kill certain insect species. Nematodes in the family St... infectious juveniles are released to inundate and kill the pest insects quickly. Depending on climate conditions, this method works best on greenhouse orna...Two chemicals boost immune cells' ability to fight HIV without gene therapy
...ral-fighting molecule and prolonged their power to kill HIV-infected cells. In this study, the scientists isolated immune cells from the blood of HIV-infected persons and cultured the cells with the chemical compounds. They were surprised to see that the compounds produced the same three changes in the c...Discovery may lead to better Candidiasis drug
...ccurring proteins, such as venoms and toxins, that kill cells by creating holes in the cell membrane," said Edgerton, "but we thought that wasn't the case with histatin. We didn't think it acted in the same way. And we wanted to know why it acts on yeast (fungus is a type of yeast) and not on other types...Understanding biological foundation of human behavior critical to improving laws
...ng even in the face of the severest penalties to kill in reaction to threats to their status. "What we're learning about development of the mind and the biology of thinking is growing at a tremendous rate," Jones said. "The main significance of this article is that it demonstrates how the legal system ...Defensins neutralize anthrax toxin
... deadly effect. Whilst defensins are well known to kill bacteria, toxin neutralization represents a novel function of defensins. Defensins are capable of perforating the bacterial cell wall thus killing bacterial pathogens. Accordingly, their antibiotic potential is currently exploited although it is not ...Desert plant may help treat insidious tropical diseases
...nd the Mojave dalea (Psorothamnus arborescens) can kill the parasites, which are a kind of protozoa that c...reds of plant extracts to see which, if any, would kill Leishmania donovani and Trypanosoma brucei, the parasitic protozoa that cause leishmaniasis and Afri...NYU study reveals how brain's immune system fights viral encephalitis
...This is critical, since the immune system does not kill infected precious neurons the way it does other cells, which can be replaced. The researchers attributed the spread of viral encephalitis to the inability of lab mice to produce sufficient amounts of interferons to fight the virus....Marine researchers deliver blueprint for rescuing America's troubled coral reefs
...of marine debris are accumulating, which injure or kill corals, seabirds, mammals, turtles and fishes; and levels of contaminants, including lead and PCBs, are high." To prevent further ecological deterioration, the research team recommended that the United States start managing its coral reefs as whole e...Institute for Medical Research scientists identify gene critical to type 1 diabetes
...something triggers the immune system to attack and kill the beta cells, so that insulin can no longer be made. That trigger is unknown, but viruses, foods and genes have all been suspected of playing a role. "We've shown that the MIF gene is crucial for the development of type 1 diabetes," said Dr. Al-Abe...Wolves alleviate impact of climate change on food supply, finds new UC Berkeley study
...wolves, unlike other predators, leave behind their kill once they've stuffed themselves, allowing scavengers to partake in the bounty. In contrast, other predators, including grizzly bears and mountain lions, will either guard or hide their kills from scavengers. Wilmers, who now holds a post-doctoral...Treated fabric kills anthrax spores
... fabric treated with an antimicrobial compound can kill dormant anthrax spores and could provide the basis... spore and the most difficult to kill. If this can kill dormant spores, then it could more easily kill germinating spores," says Jon Calomiris. Calomiris c...Yeast finding links processes in heart disease and cancer
...sensing of oxygen might offer a new opportunity to kill infectious yeast and fungi that share the gene with S. pombe. "Without the sre1 gene, the yeast in our experiments died in low oxygen conditions," says Espenshade. "Because low oxygen levels are common in infected tissues, if we can block infectious ...Genetically modified natural killer immune cells attack, kill leukemia cells
...itch" that prompts them to aggressively attack and kill leukemic cells. This finding, from researchers at St. Jude Children's Research Hospital, suggests a way to improve the outcome of children who receive treatment for acute lymphoblastic leukemia (ALL) or other blood cancers. Results of the St. Jude ...Poplar trees redirect resources in response to simulated attack
... attacks, for example, by producing chemicals that kill off the attackers or make their own leaves less tasty," said Benjamin Babst, a Ph.D. student in the biology department at Tufts University and lead author on that paper. "But there's a suspicion that plants also respond by building up tolerance, for ...Prominent North Shore-LIJ physician-researcher brings science to the masses with new book
...hing the immune weapons in amounts that injure and kill surrounding normal cells in the body's organs, like collateral damage among civilians in guerilla warfare. Dr. Tracey and his team discovered that the brain, via the vagus nerve -- the largest nerve in the body that wanders through the major organs ...Study reveals potential new target for cholesterol-lowering drugs
.... Too much or too little cholesterol can damage or kill cells. He and his colleagues next will try to determine just how the PCSK9 protein degrades the LDL receptors. Dr. Horton said the current study's results also are important because many researchers thought there might be no new ways to exploit the ...