Case Western Reserve University School of Medicine gets $4 million to make 'smart nanoparticles'
...oactivated molecules to cancerous lesions so as to kill the tumors, not the healthy tissue around them, Deliver payloads of corrective genes to treat genetic disorders, and payloads of inhibitory nucleic acids to suppress viral infections or cancers, Deliver effective drugs that are otherwise too toxi...Scripps scientists describe protein used by bacteria and cancer cells to resist drugs
...tually have very good drugs to fight cancer and to kill bacteria," says Assistant Professor Geoffrey Chang...d by other bacteria or fungi in the environment to kill off the competition. Scientists in the last century have discovered a number of these natural "antib...Disabling gene defuses rheumatoid arthritis in mice
...ggest it may be just as helpful to let these cells kill themselves and each other. "We already know a great deal about Foxo3a from studies of its role in some cancers, and hopefully that puts us in a good position to devise ways to manipulate its activity," says senior author Stanford Peng, M.D., Ph.D., ...To stop evolution: New way of fighting antibiotic resistance demonstrated by Scripps scientists
...d by other bacteria or fungi in the environment to kill off the competition. Scientists in the last century have discovered a number of these natural "antibiotic" products and have used them as the basis for treating bacterial infections. By the middle of the century, the threat posed by ma...Edible bivalves as a source of human pathogens: signals between vibrios and the bivalve host.
...aemolymph factors that act in a co-ordinate way to kill microorganisms. Our research examines available data on Vibrio interactions with both cellular and soluble components of the bivalve immune system in the light of the capacity of bacteria to evade the hemolymph bactericidal activity and to develop pa...Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
... and women in societies around the world sometimes kill themselves or someone else. In fact, studies indicate that some 40% of people who are rejected in love slip into clinical depression. Our study may also suggest some of the underlying physiology of stalking behavior," she added. Fisher noted that...Gram-negative bacteria shoot their way into cells
...fight bacterial infections with antibiotics, which kill all bacteria, good and bad. Furthermore, the researchers are optimistic that drugs of this type might be effective against pathogens that are resistant to existing antibiotics. "We believe this ring forms the foundation upon which all of the other co...Vaccine targets tumors where they live
...tumors and are locally activated there in order to kill cancer cells. A problem is that the T cells lose their tumor-killing power once they reach the environment surrounding the tumor. This happens because T cells decrease stimulatory molecules including one called B7.1. In a study appearing online on ...JCI table of contents July 1, 2005
...tumors and are locally activated there in order to kill cancer cells. A problem is that the T cells lose their tumor-killing power once they reach the environment surrounding the tumor. This happens because T cells decrease stimulatory molecules including one called B7.1. In a study appearing online on ...Virus uses tiny RNA to evade the immune system
...ed that cytotoxic immune cells were more likely to kill cells infected with a mutant virus that cannot make the microRNA than the normal virus. Thus, microRNA-induced reductions in T antigen expression promote escape from antiviral T cells without affecting virus growth. "Viruses can use the host RNA infe......ise much more quickly, be much more aggressive and kill the animals faster," said Hannon. Specifically, he said, the addition of the miRNA genes appeared to reduce the natural cell death, called apoptosis, which tends to hold tumors in check. While the major focus of cancer research has been on genes that...Plant pathologists explore using fungi to control plant diseases
... more resistant to plant diseases that may harm or kill the plant. When an endophyte is introduced into a plant, the plant reacts as if a disease is infecting it and stimulates its natural defense system. As a result, the plant protects itself against pathogens that may cause it actual harm. "This method ...NIH awards $11.9 M to The Burnham Institute to establish the San Diego Chemical Screening Center
... and HBRI include design of drugs that selectively kill cancer cells, cytoprotective drugs for reducing cell loss during stroke, neurodegeneration, heart disease, and trauma, drugs that neutralize the anthrax toxin and other bacterial toxins, radioprotective drugs, drugs that suppress inflammation and aut...Insects develop resistance to engineered crops
...nsecticidal proteins in a single plant efficiently kill insects. But when crops engineered with just one of those toxins grow nearby, insects may more rapidly develop resistance to all the insect-killing plants, report Cornell University researchers. A soil bacterium called Bacillus thuringiensis (Bt), ...Recurrent miscarriages: Could prednisolone reduce the occurrence of this distressing condition?
... is no evidence that uNK cells actually attempt to kill the trophoblast, despite their name, but they may prevent the trophoblast invading too far into the endometrium too extensive an invasion can cause the women to die of choriocarcinoma (cancer of the placenta). "We also know that pregnancy can occu...Anthrax inhibitors identified by Burnham team
...e. At late stages in the disease, antibiotics can kill the anthrax bacteria, but do not affect LF secreted by the bacteria, which is sufficiently concentrated in the bloodstream. LF enters cells and inactivates a human protein called "mitogen-activated protein kinase", or "MAPKK", disrupting the normal s...Tufts researchers shine light on firefly mysteries
...uced by their reproductive glands. These chemicals kill the sperm of other males that have mated with the same female but they are also toxic to the female -- hence conflict." In a collaborative research effort with insect physiologist and Tufts postdoctoral research fellow Dr. William Woods, Lewis is als...Study: Harmless virus kills some cancers
...t takes for a common, non-disease-causing virus to kill cervical, breast, prostate and squamous cell cance...enes, which disrupt the host cell's life cycle and kill it. Scientists have suspected that AAV2 has cancer-suppressing properties. In previous studies, Mey...Antibiotics help combat dangerous tropical disease
... the circle. 'Although the drugs currently in use kill the micro-filariae, they largely leave the adult worms unscathed,' Bonn parasitologist Professor Achim Hrauf explains. 'Due to the long lifespan of the wuchereria worms, therapy lasts several years, during which time the symptoms continue to persist....ASU's Curtiss awarded $14.8M from Gates Foundation to develop new pneumonia vaccine for newborns
...eve scientific breakthroughs against diseases that kill millions of people each year in the world's poorest countries, today offered 43 grants totaling $436.6 million for a broad range of innovative research projects involving scientists in 33 countries. The ultimate goal of the initiative is to create "...