NIH awards new $14.5 million, five-year grant to the Scripps Research Institute
...people thought it would be very difficult to solve kinase structures. Now they are being solved left and right," says Stevens. "The same could happen with membrane proteins -- we just need that technological breakthrough to unleash it."...New therapy for specific form of leukemia
...ey hope to be able to administer Glivec, and other kinase inhibitors, to treat these patients as well. Relevant scientific publications The research of the VIB scientists from Peter Marynen's group appears on 1 October in the authoritative journal, Nature Genetics (Graux C, Cools J et al., Nature Genetics...New genetic tools provide clues to the effects of exercise and diet on obesity, diabetes
... Hittel said. They found that adenylate kinase 1 (AK1), an important enzyme in regulation of cell...singly," Hittel noted, "total activity of creatine kinase (CK), which also regulates energy metabolism in skeletal muscle, increased (a significant) 30% in ob...New version of tumor-suppressor linked to progression of childhood cancer
...r new anti-cancer therapies. Neurotrophin tyrosine kinase receptor type I (TrkA) responds to nerve growth factor and plays a key role in the development of the nervous system. Mutated TrkA has been associated with many human cancers, including colon, thyroid and prostate cancers. However, previous studies h...Newly discovered protein suggests novel tumorigenic pathway
... PICT-1 may affect phosphorylation by activating a kinase or inhibiting a phosphatase. The identification of PTEN regulators has been a tremendously difficult problem and this research represents a huge breakthrough. Maehama explained that this discovery indicates that cells with impaired PICT-1 function m...Sandbagging cancer in the bloodstream
... effect of using a class of compounds known as Src kinase inhibitors to treat metastatic cancer in mice. Rat...u can imagine that a prolonged treatment [with Src kinase inhibitors] may actually help people ward off some of the most deadly and metastatic cancers," says ...VYTORIN (TM) superior again to Lipitor at lowering LDL (bad) cholesterol
...LT), aspartate aminotransferase (AST), or creatine kinase (CK) level less than or equal to 1.5 times the upper limit of normal, serum creatinine level less than or equal to 1.5 mg/dL, and a hemoglobin A1C less than 9 percent in patients with diabetes. Full indication for VYTORIN VYTORIN is indicated as...Stress impairs thinking via mania-linked enzyme
...order, may be traceable to overactivity of protein kinase C (PKC), suggests the study, funded by the National Institutes of Health's (NIH) National Institute of Mental Health (NIMH) and National Institute on Aging (NIA), and the Stanley Foundation. It explains how even mild stress can worsen cognitive sympt...JCI table of contents November 1, 2004
...hat c-Abl is a direct target of TGF-b and that its kinase activity is stimulated by TGF-b in a Smad2/3-indep...endent manner. Further, TGF-b stimulation of c-Abl kinase activity did not require PDGFR phosphorylation or expression. Use of imatinib, an FDA-approved treat...Structure of new DNA enzyme family member found
... shape is similar to other members of the riboside kinase family, proteins that are important in making DNA ...esearch group now has nine members of the riboside kinase family that are thought to have evolved from a common protein ancestor. Writing in a recent issue of...Automated scans let scientists track drugs' broad effects on cells
... specific biochemical effect is difficult, such as kinase inhibitors. Future applications may include testing the response of cancer cells with different genetic profiles to a spectrum of anti-cancer drugs, which could help predict clinical responses in individual patients. Alschuler, Wu, and Mitchi...New findings may redirect strategies for treatment of prostate cancer
...ool of Medicine at UCLA used a small molecule dual kinase inhibitor to closely examine two molecules that interact with one another and are known to enhance AR function, ERBB family members EGFR and HER2. Previous work has strongly implicated EGFR as being a key modulator of AR. Interestingly, the Sawyers g......gh a receptor complex composed of the RET tyrosine kinase and a GFR-family receptor. Tyrosine kinases, such as RET, are well-known for their function in phosphorylation cascades that span the cell membrane. The role of the GFR co-receptors in these complexes was long thought to be limited to as a co-recepto...New protein structure may aid in design of therapeutics for autoimmune disease
...have determined the crystal structure of a protein kinase C (PKC) isozyme, in this case the novel PKC family...solved in the presence of the high potency protein kinase inhibitor, staurosporine, revealing the structural basis of inhibitor binding." Dr. Somers beli...Horwitz Prize to be shared by Tony Hunter, Anthony Pawson
... successful because it blocks the wayward tyrosine kinase that drives this particular cancer. Pawson's work has provided essential insight into how cells signal each other, and has had a broad impact throughout biomedical research. In 1986, he identified protein modules that recognize specific phosp...Read your shampoo's label: Study finds common ingredient stunts developing neurons of rats
...enzyme was its target. This enzyme, focal adhesion kinase (FAK), is known to be important for outgrowth of axons and dendrites as well as necessary for cell signaling. But to kick into action, FAK must undergo tyrosine phosphorylation, whereby collections of molecules called phosphate groups are added to FA...New drug sidesteps Gleevec resistance in human trials
...is case, the drug's target is the Abelson tyrosine kinase (ABL), an enzyme that becomes overactivated by a c...awyers, who was examining how mutations in the ABL kinase could blunt the effect of Gleevec. Sawyers and Kuriyan began a collaboration to probe the problem, w...JCI table of contents, December 15 2004
...is study is the first to describe roles for an Eph kinase in in vivo immunological function and the data suggest that EphB6 is important for T cellT cell cooperation during T cell activation. TITLE: EphB6-null mutation results in compromised T cell function AUTHOR CONTACT: Jiangping Wu Laboratory of Immunol...JCI table of contents, 3 January 2005
...ions of the BRAF protein that normally inhibit the kinase activity of BRAF. BRAF is then able to transmit uncontrolled signals to normal cells that promote their division and transformation into malignant tumor cells. In an accompanying commentary, Alfredo Fusco and colleagues from Universit degli Studi...Cincinnati study of Chernobyl residents uncovers new cause of thyroid cancer
...ions of the BRAF protein that normally inhibit the kinase activity of BRAF. BRAF is then able to transmit uncontrolled signals to normal cells that promote their division and transformation into malignant tumor cells. In an accompanying commentary, Alfredo Fusco and colleagues from Universit degli Studi di ...