Protein in urine may warn of preeclampsia risk in pregnant women
...ngiogenic protein sFlt1 [soluble fms-like tyrosine kinase 1] was attaching to and absorbing two pro-angiogenic proteins, PIGF [placental growth factor] and VEGF [vascular endothelial growth factor]." Last year, in a study published in The New England Journal of Medicine, Karumanchi and co-investigators conf...Healthy cleavage: How statins protect against Alzheimer disease
...nd colleagues focused on a molecule called ROCK, a kinase enzyme that had recently been implicated in APP processing. Working in mouse neuroblastoma cells, they confirmed that two different statins increased healthy cleavage of APP. When they then blocked ROCK, the effects were similar to those of the stati...Clam embryo study shows pollutant mixture adversely affects nerve cell development
...roduction of a subunit of an enzyme called protein kinase A (PKA), which previous research suggests plays a role in neural development," says Reinisch. "Fluctuations in PKA may influence not only neuronal maturation but also how neuronal networks are constructed during development," she says. Alterations of...Plant protein mimics hormone that mitigates diabetes and obesity
...ectin and osmotin jump-start a process called "AMP kinase phosphorylation," which increases both sugar and fat use by muscle cells. "By binding to the adiponectin receptor, osmotin, like adiponectin, can control the energy status of muscle cells, " said Meena Narsimhan, research scientist at Purdue's Bindle...Steroid discoveries could add bulk to crop harvests
...heir experiments indicated that another protein, a kinase called BIN2, appeared to act negatively in the steroid pathway to modify BES1 and BZR1 proteins, which targeted these proteins for turnover. In the presence of the steroids, BIN2 becomes inactivated by an unknown mechanism, thereby allowing BES1 and ...Pro-inflammatory enzyme linked to diabetes; Immune system's macrophages may be key to treatment
...cribes research in mice that identifies enzyme IkB kinase (Ikk-) as a central coordinator of inflammatory responses in the liver and macrophages, the immune system cells which attack infections. Both control mice and mice with Ikk- deleted in specific types of cells were fed a high-fat diet that normally...Key trigger of opioid withdrawal symptoms found
... discovered that a molecular switch called protein kinase A was part of the triggering machinery involved in...it either the GABA transporter activity or protein kinase A eliminate the hyperexcitability of the PAG neurons in the mouse brain slices. The researchers cite...New drug may be formidable adversary for hard to treat leukemia
... availability of novel, high potency, Abl tyrosine kinase inhibitors will usher in a new generation of clinical studies that may result in additional major advances in the therapy of hard to treat leukemia....Study identifies mechanism of resistance to targeted therapy in lung cancer patients
...psy of the tumor and resequenced the EGFR tyrosine kinase domain. Their studies confirmed the existence of a second mutation, and insertion of this mutation into test cells rendered them resistant to gefitinib in vitro. Further analysis revealed that the newly identified mutation was altering gefitinib's d...Study examines role of EGFR gene mutations in lung cancer development
...efitinib (Iressa) or erlotinib (Tarceva), tyrosine kinase (TK) inhibitors that target EGFR. Recent studies have found that EGFR gene mutations are more common among females, patients from Japan, never smokers, and patients with adenocarcinomas, which are the same groups that have the highest response rates ...Research may provide ways to inhibit cancer's ability to resist treatments
... characterized in three dimensions--polynucleotide kinase (PNK), a key enzyme involved in a cell's ability to repair single-strand and double-strand breaks in DNA. "This gives us a clearer picture of how the enzyme works and opens up the possibility that we can develop drugs that inhibit cancer's ability to...Researchers discover a good side to cholesterol in controlling cell signals
...ymes that deactivates extracellular signal-related kinase (ERK). Overactive ERK is associated with multiple cancers. When the amount of cholesterol in lipid domains is normal, the OSBP-cholesterol complex keeps the amount of active ERK under control. When cholesterol in the domains gets too low, however, t...New tumor-suppressor gene discovered
...in product of the mats gene could partner with the kinase product of a known tumor-suppressor gene named "wts," which turned out to be the case. The researchers performed three experiments to test whether the mats and wts genes interact genetically. In the first experiment, they inserted an additional no...Scientists identify molecule that regulates well-known tumor suppressor
...et for cancer therapy. The phosphatidylinositol 3' kinase signaling pathway regulates cell growth and survival, and is inhibited by activity of the tumor suppressor PTEN. Research indicates that PTEN exerts its tumor suppressor activity by inhibiting PKB/Akt signaling that is critical for cell survival. Man...Two UCSF scientists receive top funding honor from medical institute
...ic engineering to essentially mutate an individual kinase to make it a unique target for a chemical that can control its activity, but not that of the other hundreds of kinases in a cell. In this way, he can isolate the function of individual kinases. The approach is now used by more than 100 university and...Trio of leukemias share a single mutation
... mutated gene that produces the activated tyrosine kinase responsible for the myeloproliferative disease hyp... showed the same defect in the gene for a tyrosine kinase known as JAK2. "There are some similarities among these three different diseases, and some overlap i...Glowing hearts shine light on heart disease
...cine, suggest that medicines designed to block CaM kinase activity may be useful for treating patients with ...mber of years to study the role of the protein CaM kinase in signaling pathways that underlie the heart's electrical stability and maintenance of normal rhyth...Researchers identify cause of 'early bird' sleep disorder
... the change causes a protein -- an enzyme called a kinase that is made by the gene - to be less active than normal....Automated imaging screen reveals promising drug candidates
...y-PP) that, though structurally related to a known kinase inhibitor, induced morphological changes distinct from any known kinase inhibitor. What does hydroxy-PP target? An enzyme, called carbonyl reductase 1 (CBR1), that acts on ......cused on IRAK-M (interleukin-1 receptor associated kinase M), an intracellular signaling molecule previously found only in macrophages and in circulating white blood cells. Their theory was that if IRAK-M is maintained as macrophages fuse to form osteoclasts, it would block later steps in the signal pathway...