New light microscope sharpens scientists' focus
...r biology techniques allow researchers to attach a label to each copy of a protein they wish to study. Ordi...nd their new technique are simple: The researchers label the molecules they want to study with a photoactivatable probe, and then expose those molecules to a...First-ever genomic test predicts which lung cancer patients need chemotherapy to live
...ene's activity level inside the cell. Scientists label the messenger RNA with fluorescent tags. The fluorescent RNA is then placed on a tiny glass slide, called a gene chip. There, it binds to its complementary DNA sequence on the gene chip. When scanned with special light, the fluorescent RNA emits a...Scientists solve sour taste proteins
...ir study, the researchers used fluorescent tags to label the subsets of cells that are known to be responsible for bitter, sweet, and umami taste, as well as the subsets of cells that express PKD1L3 and PKD2L1. By "reading" the tags, they found no overlap between the subsets of cells involved in the first ...Joslin's new book demystifies nutrition and meal planning for people with diabetes
...ay gatherings, eating when sick, food shopping and label reading. "No foods are forbidden for people with diabetes," says Campbell. "You can have a piece of cake on your birthday or go out to dinner," she says. "You just need to know how to count carbohydrates and sometimes limit certain foods to stay ...Protein tied to usher syndrome may be hearing's 'Missing Link'
...p of two imaging techniques that use antibodies to label a targeted protein, the team found that the distribution of protocadherin-15 along the stereocilium varies by form, with the CD3 form stationed only at the tips of the stereocilia in mature hair cells, while the CD1 form is found along the lengths of...Highlights from the June 2006 Journal of the American Dietetic Association
...o teach appropriate calorie intake values and food label reading skills to the general public." Can a High-Fiber Diet Prevent Obesity? While diets low in carbohydrates and high in protein continue to attract the public's attention, researchers at the University of Texas Austin report that "normal-weight...Nanotechnology may find disease before it starts
...s' livers. Another future step for this work is to label nanoparticles with a molecular road map of sorts, which would direct the particles to go to specific locations in the body. "The liver takes up foreign substances in the body, so it's not surprising that that's where we saw the particles," Rosol said...FDA approves extended dosing of Aranesp
...nd daily activities." The update to the Aranesp label now includes a recommended starting dose of 500 mcg once every three weeks in addition to the recommended starting dose of 2.25 mcg/kg once weekly. The new dosing recommendations are based on a randomized, double-blind, phase 3 study that evaluated ...New tools developed for studying neurodegenerative brain disorders
... Neuropharmacology. This study used antibodies to label serotonin axons so that the degenerative process could be visualized. The researchers injected mice with the chemical neurotoxin, 2'-NH2-MPTP, that Andrews discovered and has been studying for nearly two decades. "This latest study shows conclusive...Sea coral's trick helps scientists tag proteins
...matic color change "makes it possible to precisely label an object, such as a cell, organelle, or protein, with a flash of light and then to follow the object's movement over time," said Konstantin Lukyanov, whose group conducted the Dendra research in the lab of his brother, Sergey Lukyanov, a Howard Hugh...Investigational therapy denosumab increased bone mineral density with twice-yearly dosing
...placebo group (p<0.001) at one year. The open label FOSAMAX group receiving 70 mg weekly had an increase of 2.1 percent during the same time frame. Results also indicated that denosumab had a rapid onset of action. A significant decrease in serum levels of C-telopeptide, a biomarker of bone resorpti......have not had surgery, in order to seek an expanded label indication when the drug launches. As a result o...A special protocol assessment identifies the exact label claim the clinical trial will support if successful, and it is specific to each phase 3 clinical stu...Light-sensing cells in retina develop before vision
...ion of a tracing dye into the brains of animals to label and identify the ipRGCs. That has changed as the result of a technical advance developed by Daniel C. Tu and Donald Zhang, both Medical Scientist Training Program students in Van Gelder's lab, and co-first authors of this study. Tu and Zhang used a ...Penicillin, amoxicillin: Step aside for strep throat treatment
...hildren are feeling better, despite the medication label that urges parents to make sure the child finishes all the medications. The good intentions directly lead to children becoming sick on and off for weeks or months, as the strep germ isn't quite killed off but instead lingers in the child's body. The ...USC researchers track down the stem cells that create feathers
...ng the chickens water containing a non-radioactive label that was then incorporated and retained only in the putative epithelial stem cells. They showed that these cells were pluripotent-retaining the ability to differentiate into many different cell types-by taking the purported stem cells from quail-feat...New study finds common herbal supplement helps to reduce cocaine cravings
...ddictive behavior of chronic cocaine use. An open label trial, which was recently completed, indicated that cocaine-dependent patients could take NAC on an extended outpatient basis, with minimal side effects. More importantly, patients taking higher doses of NAC were more likely to complete the trial, p...Pramipexole delivered sustained efficacy in clinical trial of patients with Restless Legs Syndrome
... pramipexole treatment in a preceding 6-month open label treatment phase were randomized to receive either blinded pramipexole (n=78) or placebo (n=69) for 12 weeks. The primary endpoint of the study was assessment of 'Time to Worsening' of RLS symptoms measured using the International RLS Rating Scale (I...Biotechnology's newest chemical tool
...to extended chains. For example, researchers often label cellular components with a molecule called biotin,...as said that one potential application might be to label various sites in the ribosome -- the RNA-based site of protein production -- with bright fluorophore...... with lung cancer. In June 2005, FDA issued a new label for gefitinib that limits use to patients with cancer who in the opinion of their treating physician, are currently benefiting, or have previously benefited, from Iressa treatment. However, oncologists believe that Iressa still holds promise and con...Olfactory system detects pheromones that control reproduction
...iques that depended heavily on dyes that could not label specific populations of neurons. These experiments...hly specific tracer, permitting the researchers to label neurons with a fluorescent protein marker. This technique relied on a conditional approach that caus...