New therapy for specific form of leukemia
...timulating cell growth unremittingly. This process leads to an uncontrolled growth of immature white blood cells and thus to T-ALL. With these findings, the researchers have revealed a new mechanism for the formation of active cancer genes on circular DNA fragments. The researchers are now concentrating t...New biosensor rapidly detects deadly foodborne pathogen
...eria-contaminated foods like deli meats or cheese, leads to higher rates of hospitalization and mortality than any other foodborne illness, said Tao Geng, research associate in the department of food science and the sensor's co-developer. "The mortality rate for people with listeriosis is very high, and...World's top theoretical physicists converge to consider 'future of physics'
...ing created in that entryway. The path leads to a distinctive, charming architectural feature of the new building--a Venetian staircase--reminiscent of the walkway bridges arcing over canals in Venice. Compliance with building code necessitated a second-floor exit from the projecting wing, so ...Environmental exposures before and after birth can harm children's lungs
...eliminary evidence that the combination more often leads to cough and wheeze in boys, possibly because boys tend to have smaller airways, which may increase the risk for airway hyperreactivity or inflammation-induced respiratory symptoms. "The congestion and pollution found in most large cities can co...Anti-cholesterol drug treats Alzheimer's disease in mice
...o have the human form of the aberrant protein that leads to A peptide. Such transgenic mice develop the hallmark pathology of Alzheimer's, including brain amyloid plaque and memory deficits. The researchers found that treatment of the normal mice markedly reduced the levels of the storage form of cholester...UT Southwestern researchers uncover process for sugar-induced fat formation
... Eating meals high in carbohydrates or sugars leads the body to do several things. Some of the sugars are immediately converted to energy while the rest of the sugars are converted to fat. The sugar-to-fat conversion occurs two ways an immediate response, where enzymes are mobilized to rapidly conve...High fiber intake reduces estrogen levels in Latina women, according to researchers
...if a higher intake of dietary fiber in these women leads to a lower incidence of breast cancer. "This study provides clear evidence of an association between dietary fiber intake and circulating hormone levels in postmenopausal Latina women," the researchers note, "and potentially provides a dietary ...Gene for Joubert syndrom with excessive brain folds discovered by UCSD researchers and Harvard team
...nd how the AHI1 gene works and how its dysfunction leads to disordered brain development, it can tell us something about the biology underlying a common disorder like autism." Also important are the implications for genetic testing, Gleeson added. "We receive frequent calls from parents w...Pesticides may promote Parkinson's disease and exercise may offer protection
... protein COX-2 may play a role in the process that leads to the death of the cells implicated in the control of movement by interfering with the programmed cell death process." Przedborski intends to confirm this role for the COX-2 protein by investigating whether the intensity of cell death increases in ...Children's Hospital Boston geneticist awarded for research on muscular dystrophy
...strophin-associated proteins whose disruption also leads to muscular dystrophy. Today, Kunkel continues to explore the role of these proteins and the more than 40 genes that have now been linked with various muscular dystrophies. His lab is using microarray (gene chip) technology to systematically examine...Diabetic damage to eyes, heart, nerves, kidneys may be explained by controversial theory
...ch of the damage normally caused by hypoxia, which leads to many of the same changes in blood vessels and other tissues caused by diabetes. "We've still got quite a bit of convincing to do, but I think people are starting to recognize that this seems to be a major mechanism for producing the f...Is the zebra fish leading us to new therapies?
... deficient blood supply to the heart, for example, leads to heart attack. Medical science hopes to be able to treat such diseases in the future by stimulating the growth of new blood vessels, a form of therapy called therapeutic angiogenesis. Despite ever-growing knowledge about blood vessel formation (ang...Powerful 'toolkit' developed for functional profiling of yeast genes
...ene, so there's no back-up for a missing gene that leads to slow growth. Pan's mutant yeast are protected from collecting genetic impurities because he's added a second copy of all the genes, a cloak that temporarily obscures the effects of whatever gene is missing. He then uses a laboratory trick deve...Mayo researchers define celecoxib pathways and mechanisms for tumor reduction
...the prostaglandin pathways," Mukherjee said. "This leads to the reduction in primary breast tumor mass." She noted that in an experiment with a limited number of mice, celecoxib appeared to completely inhibit metastasis of the breast tumor. The study employed a mouse model system that closely...Tiny exosomes extracted from donor cells may be 'magic bullet' for drug-free transplants
...e capable of triggering the T cell activation that leads to transplant rejection. Additional research will be required to determine whether donor-derived exosomes will enhance the likelihood that an organ transplant from the same donor will be accepted. Under a recently awarded National Institutes of Heal...Extinction in ocean's mud presages key ecological changes
...extinct in the first place. Even though extinction leads to less sediment mixing in our models, things can ...o, reducing the total number of species eventually leads to large changes. This suggests that conservation efforts should focus not just on the seemingly imp...Duchenne Muscular Dystrophy research focuses on early mechanisms
...cell's failure to properly control calcium is what leads to the start of Duchenne Muscular Dystrophy. Preliminary work by Grange and his associates has been funded by the Muscular Dystrophy Association and the Thomas and Kate Jeffress Memorial Trust. "Dr. Grange is testing hypotheses that will change our u...UCSD researchers find effective treatment for unusual fever syndrom caused by cold exposure
...one that inhibits an abnormal immune response that leads to symptoms in FCAS-affected patients. "We witnessed a truly remarkable response and a life-changing therapy for these patients," said Hal M. Hoffman, M.D., a UCSD assistant professor of medicine and pediatrics, and the lead author of the study i...UCLA scientists uncork fountain of youth for HIV-fighting cells
...volved to avert the rampant cell growth that often leads to cancer. Yet many cancers continue growing because they undergo genetic changes and start to produce telomerase, which regenerates their cells' telomeres. Effros and first author Mirabelle Dagarag, Ph.D., hypothesized that harnessing telomerase'...Sex versus survival: A tradeoff at geographical range limits
...it of the species' geographical range. This switch leads to northern populations becoming "enormous, genetically homogeneous superclones." By comparing reproduction in natural populations versus a benign greenhouse environment, the research team learned that the reproductive switch is due to genetic factor...