Tag: "leak" at biology news

Viruses found in untreated city water

...sewer lines," Borchardt said. "Sanitary sewers can leak and it is possible the leakage is large enough to reach the wells." La Crosse's source of water is an aquifer consisting of a deposit of glacial outwash sand and gravel approximately 170 feet deep, bounded on the east by the bluffs...

Sandbagging cancer in the bloodstream

...ility to make Src kinase protein, show no vascular leak response. In laboratory studies, these animals showed a high degree of resistance to tumor metastasis. Separate experiments showed that normal mice treated with Src kinase inhibitors also acquired a high degree of resistance to the metastasis of tum...

UT Southwestern initiating trials in humans for ricin vaccine

...well as the site responsible for inducing vascular leak in the host. UT Southwestern scientists eventually created three genetically distinct non-toxic versions of the ricin A chain, two of which were effective as vaccines in mice. Dr. Vitetta said E. coli bacteria are used to produce the A chain protein,...

Study discovers serious deficiencies in 'apparently normal' heart valves

...re often fail to close properly, allowing blood to leak back through the valve when the heart contracts. The problem, known as mitral regurgitation, has typically been ascribed to enlargement of the heart and other pathological problems associated with heart disease, but the new study suggests that change...

Intervention cuts nerve damage, boosts life span

...pling proteins (UCPs) allow some of the protons to leak into the matrix, thus disrupting the electrochemical gradient and partially "uncoupling" proton flow from ATP synthesis. Mitochondrial uncoupling, in turn, lowers the membrane potential, decreases ATP production, and increases metabolic rate, among o...

Successful test of single molecule switch opens the door to biomolecular electronics

...rolyte solutions because the applied current would leak into the surrounding solution. Lindsay and his team solved this problem by applying an insulating coating to the entire probe, except its very tip, so there was minimal electrical contact with the solution. According to Lindsay, the solution is requi...

Gene variant increases risk of age-related macular degeneration

...m in which abnormal blood vessels under the macula leak blood and fluid causing rapid damage and a precipitous loss of vision. Patients with wet AMD can receive several treatments to prevent further vision loss -- including laser surgery and recently approved injections of a drug into the eye. However, a...

Protein tags regulate key ion channel

...995 and in fruit flies in 1996. Although potassium leak was first described in the 1950s when it was recog...ed to control excitation of nerves, the reason for leak had not previously been understood. The first human clone of this channel, K2P1, generated a good d...

JBC study shows that bigger isn't necessarily better for amyloid proteins

...eurons." Just how the oligomers cause the cells to leak remains to be determined. However, Dr. Glabe has his hypotheses. "The simplest explanation for why oligomers are specifically toxic is that the edges of beta sheets are toxic by causing membrane permeabilization. The native structures and the misfold...

Viral protein influences key cell-signaling pathway

...ators found that the p12 protein allows calcium to leak out of the RER, thereby causing calcium levels to rise elsewhere in the cell. "Calcium is exquisitely regulated in cells," Lairmore says. "When p12 affects that balance, it affects the activity of a variety of genes." The current study used a non-i...

New U. of Colorado polymer has applications for dentistry, electronics, automobiles

...materials today have a tendency to shrink and even leak over time as the polymer cracks due to the stresses and becomes more rigid as it sets. This often leads to additional dental problems, he said. Led by postdoctoral researcher Timothy Scott, the team published a paper on the subject in the June 10 i...

Tadpole soon to help in the fight against cancer and lymphedema

...very important colorless fluid Fluid and proteins leak out of the blood vessels during blood circulation in the body. A network of lymphatic vessels catches this extravasated colorless fluid, lymph, and transports it back to the blood vessel network. The lymphatic vessel network is of major importance. I...

New imaging technology shown to detect pancreatic inflammation in type 1 diabetes

...s, blood vessels swell, become more permeable, and leak fluid as well as small molecules carried in the fluid into surrounding tissues. In previous experiments, the researchers demonstrated that this leakage can be detected with the help of magnetic nanoparticles (MNP) and magnetic resonance imaging (MR...

Human muscle-derived stem cells effective in animal models of incontinence

...-point pressure, the pressure at which urine would leak from the bladder, had been restored to levels that would be seen normally. "In past studies we have shown that muscle-derived cells from rats have been able to restore deficient muscle in the bladder. Using human muscle-derived cells was the next ste...

Study shows how respiratory disorder slows some racehorses

...age of 14 feet (4.36 meters). EIPH causes blood to leak from the pulmonary artery into the bronchial tubes and windpipe during intense exercise, making it harder for an animal to breathe. The physical stress of racing triggers EIPH in about half of all thoroughbreds, said Kenneth Hinchcliff, the study's l...

Molecular defect found that may cause heart failure

... cardiac cycle. This allows some of the calcium to leak out. This leaves too little calcium in the SR, so strong contrations are not possible, and too much calcium outside SR, so the muscle cells remain slightly contracted and the heart cannot fully relax. As the condition worsens, the heart grows weake...

Biomarker test may give early warning of brain woes

...way to detect fragments of broken brain cells that leak into the bloodstream may help doctors more quickly and precisely treat people with severe head injuries or brain diseases, say researchers at the University of Florida's McKnight Brain Institute. UF scientists have discovered they can use an approach...

Plant wounds trigger bacteria

...d recognizes organic compounds called phenols that leak out of damaged cells when a plant is wounded. A bacterial protein called VirA acts like an antenna, detecting phenols in a plant wound; the phenols, in turn, signal VirA to add a phosphate (PO4) group to a related protein, VirG, converting it into an...

Polymer gel can block toxic leakage problem in gene therapy

...t viruses carrying anti-tumor genes have tended to leak from tumors, proving toxic to other body tissues. The researchers have developed a biocompatible polymer that briefly changes from a liquid at 39 degrees Fahrenheit to a gel at body temperatures to block most gene-bearing viruses from being diverted ...

FDA approves AVELOX (moxifloxacin HCl) for treatment of complicated intra-abdominal infections

...ma or surgery in the abdomen that cause bacteriato leak from the gastrointestinal tract into adjacent tissue there areapproximately 3.5 million cases in the United States each year, withmany patients contracting the infection secondary to appendicitis. [1] "The FDA approval of AVELOX to treat complicated ...

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