Tag: "lesions" at biology news
Inherent vascular repair key to atherosclerosis
... inflammatory response becomes most noticeable and lesions
on the artery start becoming visible," Goldschmidt explained. "What surprised us the most was to find out that what seemed from the outside to be a very complex disease may not be that complicated after all," Goldschmidt continued. "It turns out to b...
Chronic stress accelerates atherosclerosis following angioplasty procedure
...ood vessels and caused them to become blocked with lesions
containing microphages, thrombus and lipid deposits. These lesions
resembled plaques which develop in humans in a process of atherosclerosis and are the cause of vesse...
COPAXONE may repair nerve damage in MS patients
...l transection is a well-known feature of active MS lesions
and represents an irreversible stage of the disease process," said Dr. Khan. Twenty-two treatment-nave RRMS patients were included in the study. Baseline neurological assessments and magnetic resonance spectroscopy imaging (MRSI) scans were performed...
Scientists engineer mice to mimic Alzheimer's therapy
... study suggests that it may be difficult to repair lesions
once they've formed." The need to recognize and treat Alzheimer's patients at the first signs of impairment will be important to the success of potential treatments, said Joanna Jankowsky, Ph.D., a biologist at the California Institute of Technology ...
Recycled or revamped therapeutics find novel anti-cancer applications
...ess a molecular event that can promote additional lesions
in the genetic code that further facilitates mutations that promote malignancies. "The nice thing about cells that initiate autophagy is that they are incredibly susceptible to treatment to drugs that inhibit this self-consumption mechanism," Thomps...
AKT cancer cell pathway demonstrates unexpected function
...T, these animals actually develop fewer metastatic lesions
than do control mice. Taken together with our new findings, these results suggest that by inhibiting AKT, not only do you block cancer survival, you also increase cells' properties of motility and invasiveness." In other words, he says, while a majo...
MRI best tool for studying intricate nerves in dogs
...es in the dog, the clinician will better recognize lesions
affecting those nerves, such as inflammatory or neoplastic diseases, thus allowing earlier recognition of the disease," states lead researcher Laurent Couturier. Twenty-two MRI brain studies of various dog breeds were reviewed to determine which CN...
Study hints at role of stem cell genes in testicular, breast cancers
... capacity of cells to specialize, causes dysplatic lesions
in the intestines, skin and stomach. "It would be useful to look at NANOG in those places where we know over expression of OCT 4 results in tumor progression," she says. "It may be playing a role there, too." Other co-authors of the study were Uche I...
UCSF study finds nerve regeneration is possible in spinal cord injuries
...chers evaluated the effect of two peripheral nerve lesions
(injuries) in animals with spinal cord injury. One...rd injury and a second was made a week later. Both lesions
were located in the animals' sciatic nerve, which is part of the PNS. The researchers found that th...
Also in the December 21 Journal of the National Cancer Institute
...gh-grade cervical dysplasia and subsequent genital lesions
may originate from the same group of abnormal cell...in women. It is unknown whether subsequent genital lesions
and cancers arise from new HPV infections or whether they come from the same transformed cell popula...
JCI table of contents: December 22, 2005
...y role in inducing plaque rupture as rupture-prone lesions
have been shown to be macrophage-rich. Elaine Rain...-9) in the macrophages of advanced atherosclerotic lesions
in mice. The authors found that macrophages secreting an autoactivating form of MMP-9 enhanced elast...
Little known DNA repair enzyme may be a tumor suppressor gene
..., in the test tube, to efficiently extend DNA with lesions
that stop most other DNA polymerases in their tracks. Other research has shown that inactivation of this lesion-replicating enzyme in yeast leads to a dramatic decrease in the frequency of mutations induced by a wide range of DNA damaging agents. In ...
Loosen leash on cancer protein 'watchdog,' researchers say
...y trait that typically made them develop cancerous lesions
in their intestines, but our main goal was to see ...isposition generally developed about 50 intestinal lesions
within six months of birth, but mice modified for the study had only developed three or fewer within...
Losing sleep undoes the rejuvenating effects new learning has on the brain
...at people who have suffered certain types of brain lesions
may be unable to screen out irrelevant stimuli suc...s do easily. A flip side is that people with these lesions
tend to associate familiar stimuli with new information more rapidly than healthy counterparts, a ph...
Face perception is modulated by sexual orientation
...nformation? Past work has shown that patients with lesions
in orbitofrontal cortex are impaired in their ability to identify emotional facial expressions, suggesting that this region has an important role in the processing of facial cues required for social communication. In this light, the researchers sugge...
Protein finding could lead to treatment for inflammatory diseases
...nt of populations tested in numerous studies. The lesions
resemble chickenpox (a disease actually caused by ...ic infection in immunocompromised people, with MCV lesions
growing very large and persisting for much longer periods, even years, in this population, Shisler s...
JCI table of contents: January 12, 2006
...wn that leptin is expressed in active inflammatory lesions
of the central nervous system during EAE and MS, Matarese and colleagues investigated the effects of leptin blockade on the induction and progression of EAE in mice. They found that leptin blockade by the use of either anti-leptin antibodies or a for...
HPV testing a cost-effective strategy for women with equivocal cervical screening results
.... The ASCUS and low-grade squamous intraepithelial lesions
(LSIL) triage study (ALTS) was launched in the late 1990s to determine the best management strategy for women with these Pap test abnormalities that would both maximize the detection of clinically significant disease and reduce the need for unnecessa...
Stopping the clock: Genetics of tumor latency in skin cancer
...ich Gli1 is partially stabilized) develop BCC-like lesions
at an earlier age. Remarkably, mice with mutated f...e) die at birth, presenting severe ulcerating skin lesions
similar to human BCCs. This work convincingly shows that Gli protein accumulation contributes to the...
Nuclear medicine imaging allows prediction of breast cancer patients' response to hormonal treatment
...d when metastasis occurs--to evaluate if the tumor lesions
are hormone sensitive and to assess what treatment...enever needed in the course of the disease for all lesions
at one time," she added. While SRS is routinely used in nuclear medicine for diagnosis, Belgian and ...
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