Tag: "lethal" at biology news
Time running out for South Asian vultures, ecologists warn
...inary dose of diclofenac shortly before death were lethal
to captive vultures and that a high proportion of wild vultures found dead in Pakistan were contaminated with diclofenac and had the same symptoms as the poisoned birds in their experiments. The most recent population surveys in India, carried out by...
Research team develops nonhuman primate model of smallpox infection
...irus, the causative agent of smallpox, can produce lethal
disease in monkeys. Smallpox, a devastating diseas...aving demonstrated that it was possible to achieve lethal
infection of primates using variola virus, the team next tried to determine whether lower doses of v...
Embryonic stem cells correct congenital heart defect in mouse embryos
...e hearts were genetically predisposed to develop a lethal
defect, rescued the heart from developing the disorder by not only producing normal daughter cells that were incorporated into the defective embryonic heart but also by releasing biological factors into the nearby vicinity. This prevented neighboring...
New study on smallpox in monkeys reveals tactics of a killer
...mallpox on cells to other pox viruses and use less lethal
pox viruses in the search for smallpox countermeasures. CDC has the only U.S. laboratory facility in which research using smallpox virus is permitted. However, many more labs in the United States have sufficient safety features for handling les...
Muscling in on a deadly cancer
..., but until now, no mouse had developed the highly lethal
alveolar rhabdomyosarcoma. Capecchi says cancer specialists have believed alveolar rhabdomyosarcoma originates in satellite stem cells because the tumors proliferate after birth, when stem cells retain their ability to proliferat...
Powerful 'toolkit' developed for functional profiling of yeast genes
...technique identified 116 genes that were synthetic lethal
with a gene called cin8 and confirmed their involvement. Of these genes, 73 had not been identified by other techniques. The new technique missed just 16 genes previously identified and confirmed by the older techniques. Boeke's goal is to u...
Finding could improve safety of stem cell transplants
...least in the culture dish, when they added PAR-4's lethal
dance partner, ceramide, to the mix, PAR-4- and Oct-4-expressing cells again died before they could do harm. The ceramide analogue, N-oleoyl serinol, or S18, also increased the proportion of nestin-containing cells in cell cultures and gr...
UT Southwestern initiating trials in humans for ricin vaccine
...luated for their ability to protect mice against a lethal
ricin challenge. As far as we can tell, the vaccin... patients. Injected RiVax protects mice against 10 lethal
doses of ricin and has no side effects in mice when given at 100 times the dosage required for an im...
Vaccination with anthrax capsule protects against experimental infection in animals
...erium that causes the disease, protected mice from lethal
anthrax infection, according to scientists at the ...ter the second dose, the mice were challenged with lethal
doses of spores from a strain of anthrax producing only the capsule. In the group that had received ...
Read your shampoo's label: Study finds common ingredient stunts developing neurons of rats
...00 times the dose used in their current study was lethal
to these cells. To understand what effect chronic exposure would have on immature, developing neurons, the researchers kept cells in a media solution containing low concentrations of MIT for 18 hours. In a standard culture, an immature neuron will i...
What have scientists learned since Mount St. Helens erupted?
...ering lakes, which shielded aquatic organisms from lethal
volcanic forces. If it had been at night, the nocturnal animals would have been exposed to lethal
volcanic forces. Instead, they had returned to the safety of their subterranean burrows." Species ...
New route to Parkinson's found in cells' 'garbage disposal' system
...lity causes such protein garbage to aggregate into lethal
clumps in neurons--a hallmark of many neurodegenerative diseases. In the brain, the parkin protein works with Hsp70, which helps correct the folding of misfolded proteins. BAG5 is one of a family of BAG proteins known to interact with other proteins...
Poison digs its own grave
... their concentration in the fungus falls below the lethal
dose. Schoonbeek studied the genes involved in the secretion of toxic substances by ABC transporters. He discovered that the activity of the pumps was partly controlled by the toxic substances. Upon entering the fungus, these stimulate the fungal DN...
Suspect protein found to play protective role in chronic lung disease
...ls of the signaling molecule and swiftly develop a lethal
respiratory disease that combines the features of asthma, COPD, and pulmonary fibrosis. The mice provide a research model for understanding the adenosine signaling pathway because they permit researchers to knock out one of the four receptors at a ...
Plant protein mimics hormone that mitigates diabetes and obesity
...r," she said. Whether osmotin also has a similarly lethal
effect on any types of mammalian cells remains to be seen; however, osmotin, when bound to its receptor on yeast cells, does kill those cells, Narsimhan said. "What's interesting about this research is that is raises so many questions," she said....
Blocking cell signaling can stymie viral infections, study shows
...s are thought to have little immunity to the often lethal
disease. The NIAID grant supports research into th... carries a protein much like SPGF), which causes a lethal
pneumonia in mice. As hoped, the animals were protected from developing the disease. In the new stud...
Heart specialists call for cardiovascular screening for all young competitive athletes
...ortality of the increased detection of potentially lethal
problems. It was harder to detect premature hardening of the coronary arteries or abnormalities in the coronary artery in young competitors, he said, because baseline ECG signs of blood flow (ischaemic) problems were scarce. However, his research tea...
Gene used in brain development can cause childhood brain cancers
...l trials using ATRA in the treatment of a commonly lethal
pediatric disease." Yan said that the OTX2 gene normally contributes to development and growth of certain areas of the brain, such as the cerebellum, but the gene is generally turned off and no longer used after birth. Using a novel technique that in...
Clues on cancer from a zebrafish model of melanoma
Melanoma, the most lethal
form of skin cancer, is an epidemic among cancers; it claims thousands of lives every year. Despite advances in cancer genetics and treatments, current therapies are only mildly effective once melanoma has become metastatic. Understanding the genetic...
Physicians recommend screening for toxoplasmosis for all pregnant women, newborns
...ndii, toxoplasmosis can be harmful and potentially lethal
to the children of women who acquire the infection during pregnancy. In the February issue of the The American Journal of Obstetrics and Gynecology, the researchers report that current clinical practice -- taking a careful history and performing a ph...
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