Tag: "leukemia" at biology news
JCI table of contents: Aug. 9, 2007
...?id=29134 ONCOLOGY: New SNP for acute myeloid leukemia
Tumor suppressor proteins are so called because... expression of the PU.1 gene develop acute myeloid leukemia
(AML). When researchers from Harvard Medical School, Boston, analyzed the equivalent URE in humans t...
U-M researchers find family of 'on switches' that cause prostate cancer
...re known to play a role in blood cell cancers like leukemia
and lymphoma, and in Ewing's sarcoma. A fused gene...mbination that plays a role in chronic myelogenous leukemia
led researchers to develop the drug Gleevec, which has dramatically improved survival rates for that...
Aggressive therapy best for certain AML patients
COLUMBUS , Ohio A new study suggests that acute leukemia
patients whose cancer cells show a genetic change ... The findings apply to people with acute myeloid leukemia
(AML) whose cancer cells have normal-looking chromosomes and a gene mutation called MLL-PTD. Typi...
UF to lead research on life-threatening fungus
...death from infection in bone marrow transplant and leukemia
patients, as well as among those who receive certain other solid organ transplants, he said. About 15 percent of all bone marrow transplantpatients, for example, will develop an infection from Aspergillus; of those, about two-thirds die. "We haven'...
Adult survivors of childhood leukemia exercise less, worsening high risk for obesity and illness
.... While survivors of childhood acute lymphoblastic leukemia
(ALL) face an increased risk of developing serious health complications as a result of their cancer treatment, for a variety of reasons many avoid simple exercise and healthy lifestyle changes that could reverse the damage, according to a team of res...
Molecular detectors may refine cancer treatment
...d molecular probes to detect subtle differences in leukemia
cells from patient samples, an achievement that co... different treatments. Current tests to diagnose leukemia
use antibodies, proteins that have the ability to identify harmful substances. But such methods do n...
Scientists gain important insights into acute promyelocytic leukemia
...sms involved in development of acute promyelocytic leukemia
(APL) and identifies promising new avenues to deve...avenues for therapeutic targeting of RARA-mediated leukemia
but also shed light on oligomeric transformation mechanisms reported with various leukemia-associate...
Gene's activity points to more lethal subtype of AML
...ETS-related gene), has also been linked to chronic leukemia
and to breast and prostate cancer. The findings apply to acute myeloid leukemia
(AML) patients with leukemia
cells that have normal-looking chromosomes, a feature that occurs in ab...
Researchers identify genetic mutation that may alter tumor cell proliferation
...n validated with oncology drugs such as Gleevec in leukemia
and Herceptin in breast cancer....
'Modular' leukemia drug shows promise in early testing
... has shown promise in treating chronic lymphocytic leukemia
in both test tube and early animal tests, a new st...gets a protein called CD37 on the surface of these leukemia
cells. The study shows that the agent can successfully attach to the protein on the leukemia
Support for chromosomal theory of cancer found in cancers' development of drug resistance
...ndered less useful because the aneuploid nature of leukemia
has led to resistance. In fact, he said, this resi...st another cell "poison" that happens to kill more leukemia
cells than normal cells. Development of drug resistance in cancer is one of the strongest argument...
Damon Runyon names new class of rising stars in cancer research
..., is designing new cell and mouse model systems of leukemia
and glioblastoma to investigate the relationship between cellular energy production, growth and survival. Yu Wong, MD, PhD, with his sponsor Mark M. Davis, PhD, at Stanford University, Stanford, California, is developing a novel method to monitor the...
Cord blood may preserve insulin levels in children with type 1 diabetes
...tore a patients immune system after treatments for leukemia
or lymphoma. UF researchers identified children recently diagnosed with type 1 diabetes whose families banked their umbilical cord blood at birth. Most were still producing a small amount of insulin. The researchers then gave seven patients ages 2 ...
A faster way to recover from chemotherapy and marrow transplant
...undergo chemotherapy or bone marrow transplant for leukemia
and other cancers recover their immune function more quickly. In the June 21 issue of Nature, they demonstrate that a stable analog of prostaglandin can enhance the blood-forming system, both during embryonic development and after its been damaged. ...
Researchers shed light on mechanism of action used by anti-cancer drug
...ournal of Biologic Chemistry, showed that in human leukemia
cells, sorafenib lethality was less a consequence ...esent work, Grant and his team found that in human leukemia
cells, sorafenib induces a process known as endoplasmic reticulum (ER) stress, which results from ac...
ChemGenex announces publication confirming activity of Ceflatonin in T315I-Positive CML
...latonin against Gleevec-resistant, chronic myeloid leukemia
(CML) associated with the T315I Bcr-Abl mutation. The T315I mutation is known to confer resistance to both Gleevec (imatinib mesylate) and second-generation tyrosine kinase inhibitors (dasatinib and nilotinib). Recent publications indicate that the ...
Studies to find better ways to preserve human eggs, ovarian tissue under way
...roductive Laboratories of Augusta. Treatment for leukemia
and cervical, ovarian, breast or other cancers often leaves women infertile because systemic chemotherapy and more focused radiation therapy, designed to kill rapidly spreading cancer cells, also can destroy dynamic reproductive tissue. I dont thi...
UCLA researchers reprogram normal tissue cells into embryonic stem cells
...atopoetic cells to create a new blood supply for a leukemia
patient, motor neuron cells to treat Parkinsons disease. If we can recreate this in human cells, it has significant implications for regenerative therapies, said Kathrin Plath, an assistant professor of biological chemistry, a researcher with the ...
Researchers discover inherited mutation for leukemia
... increases a person's risk for chronic lymphocytic leukemia
(CLL), one of the most common forms of the disease...sease expected this year in the United States. The leukemia
is slightly more common in men than women, and typically strikes people who are in their 50s, 60s an...
Other highlights in the May 16 JNCI
...d Risk of Second Cancers Survivors of childhood leukemia
and lymphoma, particularly Hodgkin lymphoma, are a... rates of second cancers in survivors of childhood leukemia
and lymphoma with the cancer rate in the general population. They used a very large dataset that inc...
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