Tag: "leukemias" at biology news
New protein structure may aid in design of therapeutics for autoimmune disease
... cell mediated disease processes, including T cell leukemias
and T cell mediated autoimmune and respiratory diseases such as asthma."...
Researchers discover a stem-cell switch lurking within leukemias
...that specific cancer-causing genes associated with leukemias
can transform mature white blood cells into leukem...because it fits so nicely with what we known about leukemias
-- that we can treat patients into complete remission, and yet they ultimately relapse in most cases...
Trio of leukemias share a single mutation
that affect as many as 100,000 people in the Unite...which is presently treated with Gleevec. The three leukemias
that share a common genetic cause are polycythemia vera (PV), essential thrombocythemia (ET) and mye...
Study finds enzyme activity promotes rare form of leukemia, offers potential target for new drugs
...ns involving MLL are most often found in childhood leukemias
and as a secondary cancer in adults who have undergone chemotherapy to treat a previous leukemia. Individuals with MLL translocations have an especially poor prognosis, with less than a 50 percent survival rate. "There are more than 40 proteins tha...
Other highlights in the June 1 JNCI
...ave a higher risk of developing childhood lymphoid leukemias
and lymphomas in addition to epithelial tumors later in life. Studies have also indicated that individuals who carry one mutated copy of the ATM gene (i.e., heterozygous mutation carriers) may have a higher risk of breast cancer and perhaps other can...
Brown-Harvard team solves mobile DNA's surgical sleight-of-hand
...hat cause disease or tumors that result in certain leukemias
or other cancers. But what do the surgeons look like that conduct these intricate snip-and-solder procedures? While scientists have studied site-specific recombination for about 30 years, much remains a mystery. In the current issue of Nature, a Brow...
Learning how leukemia comes to life
...ationale to test signal transduction inhibitors in leukemias
characterized by activating mutations of receptor tyrosine kinases....
Cancer gene MYC shown to activate gene involved in metastasis
...ast, ovaries, lung, prostate, and skin, as well as leukemias
and lymphomas. MYC is a regulator of other genes--a transcription factor--and scientists have been working for more than two decades to identify its target genes in order to understand how MYC causes so many cancers. Now, scientists at The Wistar In...
U of MN researchers use human embryonic stem cells to kill cancer cells
...hat are able to treat and fight cancer, especially leukemias
and lymphomas," said Dan Kaufman, M.D., Ph.D., assistant professor of medicine in the Stem Cell Institute and Department of Medicine at the University of Minnesota and lead author of the study. "We hear a lot about the potential of stem cells to tr...
Leading researchers from Israel and Southern California to present stem cell symposium
...sponse and growth regulation mechanisms related to leukemias
and metastasis of certain cancers to the bone marrow. "Rarely Pure and Never Simple: Paradigms from the Bone Marrow," presented by Gay M. Crooks, M.D., a member of the Gene, Immunology and Stem Cell Therapy Research Program at Children's Hospital L...
Little known DNA repair enzyme may be a tumor suppressor gene
...and a slew of human cancers, including a number of leukemias
and lymphomas, are associated with chromosomal instabilities in this particular region of chromosome 6. "Although it requires further investigation, we believe that mutations in this part of chromosome 6 could occur during the development of some can...
Retinol for combating leukemia cells
...o get these types of leukemia cells. Lymphoblastic leukemias
are, as their name indicates, a type of leukemia t...e taken into account if a pharmaceutical to combat leukemias
based on retinamide is to be marketed. Moreover, according to the researchers, future treatment wil...
Oncogenic role for Bcl-3
...ativeoncoprotein Bcl-3, which is expressed in some leukemias
and solidtumors, potently suppresses p53 activation through a mechanism thatinvolves the controlled upregulation of Hdm2 gene expression. Additionally, they found that Bcl-3 is activated by DNA damage and isrequired for p53 to control Hdm2 gene expre...
A broken stress response system can contribute to Gleevec resistance
... in patients with ALL, but not CML, can cause some leukemias
to resist Gleevec treatment. Patients with CML who are taking Gleevec readily go into remission, and their cancer cells stop growing while they are maintained on drug therapy. Sherr explained that Gleevec's impact has been truly revolutionary. "It's...
Can you hear me now? Scientists find previously unknown receptors on adult stem cells
...ty, could have important implications for treating leukemias
and autoimmune diseases such as lupus and rheumatoid arthritis. "We have long known that so-called hematopoietic (blood) stem cells create the blood cells that are the front-line soldiers in the body's immune system," said Paul Kincade, Ph.D., the se...
Mutations point the way to new leukemia drugs
...ing JAK-STAT signaling should be effective against leukemias
caused by either mutation. In a study publish...und a mutation in a gene called MPL in a subset of leukemias
that lacked the more common JAK2 mutation. HHMI medical research fellows are medical students who co...
Study identifies molecular process underlying leukemia
...ic leukemia (ALL) and acute myeloid leukemia (AML) leukemias
develop when certain chromosomal abnormalities disrupt the genes that control blood cell formation. Without the proper instructions from these genes, blood cells produced by bone marrow never fully mature; these immature cells, which can't carry vita...
Researchers map out networks that determine cell fate
... to rejuvenate damaged tissues. Understanding of leukemias
also could be aided by insight into this regulatory circuitry, Singh said. Many leukemias
exhibit mixed-lineage patterns of gene expression, for example of both macrophage and lymphocyte ge...
Lost in the labyrinth
...begin an inappropriate type of reproduction. Acute leukemias
and other forms of cancer cells derive from defects such as this. Understanding the processes by which they form will require pinpointing the forks in the road where things go wrong."...
Case Western Reserve University licenses methoxyamine to Tracon
...ents with brain cancers, melanoma, lung cancer and leukemias
and perhaps other cancers," said Gerson. Under the licensing agreement, TRACON will develop and manage clinical trials of Methoxyamine. "We are excited to be able to develop Methoxyamine. Chemotherapy represents the most commonly used class of a...