Tag: "leukemic" at biology news
Stronger therapy better for AML with normal genetics
...nter remission. AML patients are in remission when leukemic
cells are not microscopically detectable among the... it may be that the spleen is a sanctuary site for leukemic
cells and needs separate treatment." A diagnosis of AML routinely includes studying patients'...
Researchers discover a stem-cell switch lurking within leukemias
...kemias can transform mature white blood cells into leukemic
cells that have all the properties of stem cells. ... we now have the tools we need to understand how a leukemic
change turns a normal cell into a cell that looks like a stem cell. Such studies will yield two bene...
Man and mouse share genome structures
... technology to characterize chromatin structure in leukemic
cells and gain insight into the molecular basis of disease. "The human genome still has many surprises lurking within it," said Lander, director of the Broad Institute and senior author on the study. "One of the most important is the mystery of how g...
JCI Table of Contents, March 1, 2005
The very unexpected life and death of a leukemic
cell B cell chronic lymphocytic leukemia (CLL) i...d his team calculated birth and death rates of the leukemic
cells and found that, contrary to expectations, production and destruction of CLL cells is highly va...
The very unexpected life and death of a leukemic cell
...d his team calculated birth and death rates of the leukemic
cells and found that, contrary to expectations, pr...a that CLL is a purely accumulative disorder where leukemic
cells accumulate because they cannot die. Clearly CLL is a disease in which there is a dynamic inte...
Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
... blood cell that gives rise to CLL, the biology of leukemic
lymphocytes and the clinical course of CLL as it relates to the biology, the authors then offer a unifying hypothesis for the development, growth and evolution of the disease, and complete the review with a discussion of the clinical implications for...
Genetically modified natural killer immune cells attack, kill leukemia cells
... that prompts them to aggressively attack and kill leukemic
cells. This finding, from researchers at St. Jude ... would become potent killers when they encountered leukemic
cells. In order to grow large populations of NK cells, the team started with samples of blood contai...
Next-era targeted therapy overcoming Gleevec's shortcomings
...osine kinase protein that triggers rapid growth of leukemic
cells. Gleevec was hailed as the first approved drug to directly inhibit the activity of an enzyme known to cause uncontrolled cell growth, and it has been highly successful for many patients. Scientists soon recognized, however, that some patients d...
JCI table of contents June 1, 2005
...php?id=23445 ONCOLOGY How normal B cells become leukemic
cells B cell chronic lymphocytic leukemia (CLL) is a disease in which outcome can be at least partially predicted by whether the patient has mutations in the B cell receptor (BCR) or not, the latter of which predicts the more favorable clinical outco...
JCI table of contents, July 1, 2005
...major hurdle has been the risk of contamination by leukemic
cells, which may induce relapse. Now, in a study a...can be distinguished and completely separated from leukemic
cells in mice, and then harvested and preserved. These cells were then transplanted into the gonads ...
Master regulatory gene found that guides fate of blood-producing stem cells
...l versus differentiation so that all the immature, leukemic
cells differentiate and die. Over the past 10 years, several gene families have been suggested to be important in regulating HSC fate-for example homebox, wnt, notch 1, and telomerase genes. Emerson and colleagues figured that one transcription fac...
VCU Massey Cancer Center researchers find new agent inhibits Leukemia cell survival
...s Mcl-1, which plays a critical role in protecting leukemic
cells from apoptosis. "What was even more interesting was that Bay 43-9006 appeared to reduce Mcl-1 levels by an unusual and unexpected mechanism-inhibition of the initiation of protein synthesis," Grant said. "This insight into the mode of action of...
Stanford/Packard scientist's data-mining technique strikes genetic gold
...ene in which the expression drops significantly in leukemic
cells. They also confirmed these relationships by studying genes known to be associated with muscle tissue in both humans and mice. Their classification system was stymied, however, when scientists included too much or too little information in the t...
Mouse model reveals that oncoprotein induces abnormal preleukemic blood cell progenitors
...e appearance of abnormal progenitor cells that are leukemic
precursors. Mice expressing CBFB-SMMHC developed AML with a median latency of approximately five months, with the time of disease onset varying with the number of abnormal cells in the bone marrow. Interestingly, additional studies showed that the bl...
Protein that regulates the recovery of blood cells from radiation and chemotherapy
... lead to a better understanding of the behavior of leukemic
cells and may have vital clinical applications for...fter myelosuppression, it is possible that certain leukemic
stem cells may also be protected from these same treatments. "Myelotoxicity induced by chemotherapy ...
Mutation in blood stem cells provides clues to cancer development
...ms of blood cancer is partly due to a reservoir of leukemic
stem cells that are resistant to current therapies. The discovery of the JAK2 mutation in stem cells in patients with PV is an important first step in developing treatments which target the earliest population of cells which propagate the disease." ...
Mouse strain with gene stutter will help leukemia research
...the partial tandem duplication occurs early in the leukemic
process and that additional mutations are needed for the disease to occur," Dorrance says. "That's what we're now focused on." "Ultimately," Caligiuri says, "we believe that this mouse will further our understanding of how leukemia develops and ope...
When Gleevec is not enough
...ill activated by BCR-ABL in imatinib-treated mouse leukemic
cells. When Li treated the mice with a compound, d...ese results are encouraging, a small population of leukemic
cells (fewer than 1 percent) persisted through treatment with imatinib or dasatinib and led to a rec...
Tailored treatments: Promising designer drug provides new insight into cancer biology
...1 through RNA interference restored sensitivity of leukemic
cells and definitively identified MCL-1 as an ABT-737 resistance factor. The researchers suggest that specific BCL-2 family proteins may define resistance to this BH3 mimetic. In a separate study, Dr. David C.S. Huang from The Walter and Eliza Hall ...
JCI table of contents: January 2, 2007
... ONCOLOGY BCL2 reins in BIM, preventing leukemic
cell death Cancer is caused when a population of cells starts to grow in an inappropriate and uncontrolled manner. In many cancers the tumor cells express increased levels of a family of proteins (that includes BCL2 and MCL1) that protect them f...