Safety and immunogenicity data available for new pertussis booster vaccine candidate for adolescents
...he use of Boostrix induced anti-pertussis antibody levels which exceeded (by 1.8 to 6.9 times) those observe...nd tetanus; In the Boostrix treatment group, the levels of anti-pertussis antibodies, anti-PT, anti-FHA and anti-PRN were measured and were found to exceed ...JCI table of contents November 1, 2004
...Levels in the General Population High cholesterol levels are a major contributor to heart disease in partic... mutations in one of the ABCA1 genes may alter HDL levels in the normal population. Anne Tybjrg-Hansen and colleagues at Copenhagen University Hospital now pr...Sleeping, waking, ... and glucose homeostasis
... ability to regulate sugar levels. Sugar (glucose) levels must be maintained within fairly narrow limits for...ed. In normal mice they observed a peak in glucose levels early in the day. This diurnal regulation was lost in the mutant mice. Furthermore, whereas the no...Mutations in transporter protein effect HDL levels in the general population
High cholesterol levels are a major contributor to heart disease in partic... mutations in one of the ABCA1 genes may alter HDL levels in the normal population. Anne Tybjrg-Hansen and colleagues at Copenhagen University Hospital now pr...Other highlights in the November 3 JNCI
... Cancer Risk Greater height and obesity and lower levels of physical activity are all associated with an increased risk of endometrial cancer, according to a new study. Obesity is an established risk factor for endometrial cancer, and there has been some evidence that body mass at younger ages, weight chan...Research team discovers possible genetic mechanism behind congenital heart defects
...Ai, the team developed mouse models with different levels of the protein. They were then able to see the effects of the suppressed protein using optical projection tomography at the Mouse Imaging Centre at Sick Kids. Knockout mice, where a specific gene is replaced, or removed, allow researchers to have pre...Researchers discover transport molecule that allows boron into cells
...d minerals, too much is as bad as not enough. High levels of boron are toxic. Dr. Muallem's group showed that human cells with NaBC1 grown in culture specifically took up boron from solution when compared to arsenic, which is chemically similar to boron. Arsenic was unable to enter cells. Similar activi...U-M researcher examines the cell's housekeeping habits
...rect problems without destroying the cell." High levels of autophagic vesicles also have been noted in some forms of degenerative muscle disease, and in degenerative nervous system diseases like Huntington's, Parkinson's, Alzheimer's and ALS, (Lou Gehrig's disease). But it's not clear why the vesicles ar...Cell enzyme may help suppress cancer development
...y that the silencing of PTPRO alters the phosphate levels of some of these proteins and helps initiate processes that lead to cancer. In this study, Jacob and his colleagues show that the PTPRO gene is silenced gradually by a process known as methylation. Methylation causes the addition of small chemi...Scientists find acid rain an unlikely ally in the battle against a greenhouse gas
...tain and Sweden they attempted to determine if low levels of sulfate, like those in acid rain, affected meth... to climate change. They also predict that sulfate levels in rainfall will increase, especially in Asia. The authors have attempted to predict how this ecolog...NASA & partners create new worldwide coral reef library
...d data. "There has been amazing cooperation at all levels to assemble this data," said Frank Muller-Karger of USF. "It will serve as a source of data for projects around the world," said Serge Andrfout, who led data collection and mapping at USF. He is now with the French Institut de Recherche pour le ...Mayo researchers define celecoxib pathways and mechanisms for tumor reduction
...ins in cells. In the Mayo study, celecoxib reduced levels of COX-2 protein in mammary tumor cells; the therapy was even more effective in minimizing the amounts of COX-2 dependent prostaglandin E metabolites in mammary tumor cells. "Celecoxib treatment appears to exert its antiproliferative, antiangiog...Sexual competition drives evolution of a sex-related gene
...titutes the first specific evidence that different levels of sexual competition produce different genetic ef...said Lahn. It had been established previously that levels of polyandry -- the mating of one female with more than one male -- affected physiological traits. F...A new target for control of obesity
...e mice with early-onset obesity that had increased levels of leptin, insulin, glucose, and triglycerides. Furthermore, the mice could gain weight by eating normal amounts of food, which supports a role for Shp-2 in metabolism. "Shp-2 has different functions in each cell," says Dr. Feng. "We found th...Look at past sea-level rise points to troubling future
...eological Society of America shows that rising sea levels of as little as a half-meter per century have been sufficient to dramatically change the shoreline of the U.S. Gulf Coast within the past 10,000 years. The findings are significant because half-meter increases are within the moderate range of predict...Scientists uncover secret to sharp teeth
...rchers found that follistatin was expressed at low levels in active ameloblasts and at much higher levels in the dental epithelial cells lining the enamel-free surface of the incisors. Mice engineered to l...New source for heart bypass replacement blood vessels: Fibrin-based TEVs
... increased mechanical strength (and) physiological levels of blood flow and vasoreactivity," according to a paper published online in the American Journal of Physiology-Heart and Circulatory Physiology. Currently, blood vessels are usually "harvested" from the patient's own leg, often causing pain and disco...Asymmetric organs and microRNA-directed DNA modification
...en microRNAs and DNA methylation. In general, high levels of methylation are associated with low levels of transcription while low levels of methylation are associated with high transcription rates. "To t...Young adults who maintain their weight have lower risk factor levels for heart disease
...ven if they are overweight, have lower risk factor levels for heart disease and are less likely to develop m...factors: high blood pressure, high glucose (sugar) levels which can indicate risk for diabetes, high triglyceride levels, low levels of good cholesterol, and ...Sea change: Skeletons of ancient corals different from today's
...d to test how modern corals respond to the ancient levels of magnesium and calcium because these chemicals, along with carbon and oxygen, are the building blocks of their skeletons. More important, however, is that the ratio of these two chemicals determines whether the aragonite or calcite mineral will for...