Commandeering cellular machinery: recognition mechanism to detect small molecules
... up the receptor pocket. The goal was to create a library containing 32,768 different variations in the hope of creating and then finding a few re-engineered receptors that would have the ability to bind to a molecule known as LG335. (LG335 is structurally similar to Targretin, a pharmaceutical developed...'Immediately open access' option for the leading journal Genome Research
...nome Research" Inglis said. "We plan to engage the library community in a dialogue as our experience with this option grows, to make sure the journal's ability to contribute to the advance of science isn't undermined." Dr. Hillary Sussman, Managing Editor of Genome Research added, "It is clear that some scie...World's top theoretical physicists converge to consider 'future of physics'
...st floor Founder's Room and second floor two-story library at one end and the divided stairway with its centered French window at the other, and the corridor between runs through a series of rectilinearly shaped spaces. That area of divided stairs is the principal interaction space of the building. ...New Jersey Institute of Technology professor to develop supersized virtual library
...evelop the software. Holdings in the virtual mega library will include the home library's on-line catalog, d...urce network, the Science@NASA educational digital library and books on sale at Amazon.com that pertain to any item a user selects on the computer screen. The...Globetrotting pollutants turn up on Toronto street
...al signature. Evans says that once they build up a library of particles, this research could make it possible to identify pollutants without any knowledge of their origin. ...Newly discovered protein suggests novel tumorigenic pathway
...e and the Tokyo Metropolitan University screened a library of human brain cDNA to find proteins that interact with PTEN. They identified a new protein that binds to the C-terminus of PTEN and named it PICT-1 ( p rotein i nteracting with the c arboxyl t erminus 1). Maehama and his colleagues discovered ...Tufts Veterinary School scientists decode Cryptosporidium genome
...ists constructed a bacterial artificial chromosome library for this research project. "This library is important for building a scaffold of the genome, on which the smaller sequence assemblies are ali...NASA & partners create new worldwide coral reef library
... reef images is the basis for a new Internet-based library for the Millennium Coral Reef Project. It was crea... future research. The project will also serve as a library for coral reef remote sensing data. A distribution network has been developed to make the data avail...By impounding iron, FHC foils cell suicide, fuels inflammation
...rvived. Several rounds of this process produced a library of potential protective genes. Next, they used microarrays to detect the genes that were boosted most though this selective process. "This system told us which genes were most enriched by selection," Franzoso said, which provided "a semiquantitati...NIEHS to develop new RNAi library to help fight disease
...lly-related disease. NIEHS will develop a new RNAi library to help fight disease through its National Center ...the environmental response genes, we're building a library of RNAi molecules that'll help us fight diseases." The NIEHS project differs from what others are do...NIH makes award to UNC for Genome Fingerprint Scanning program
...is the equivalent of being able to harness a whole library of information without an index." Current software for protein identification is limited mainly to those for which a gene or protein entry exists in one of the public databases. Protein identification cannot be effectively performed for organisms wh...BioMed Central announces publishing partnership with The Scientist magazine
...entral platform. BioMed Central will now offer its library customers The Scientist print and online subscript...cause they provide a world-class offering to their library customer base and our partnership fuses an outstanding product with an excellent service provider." ...Immune system contributes to evolution of a new fluorescent protein
...ly tedious and time-consuming, and the size of the library of mutant genes is limited by the efficiency with which we can introduce at most one mutant copy of the gene per cell. If two different mutant genes end up in the same cell, the effect of the good mutant would be diluted and masked by the not-so-good...NYU researchers simulate molecular biological clock
...life cells. Their model was validated with a large library of data on the concentrations of the molecular species within the mouse molecular clock at different times of the day and data on the behavior of mice with circadian clock mutations. The results of their computer simulations showed that reliabl...Key molecule in plant photo-protection identified
...e out something like it was Colonel Mustard in the library with the lead pipe," he says. "When we began this project, we didn't know who did it, how they did it, or where they did it. Now we know who did it and how, but we don't know where. That's next!"...DNA molecules used to assemble nanoparticles
... practical. Instead, the Baker group will create a library of single-functional dendrimers that can be synthesized in parallel, rather than sequentially, and then linked together in many different combinations with the DNA strands. "So it's like having a shelf full of Tinker Toys," Baker said. An array of ...Researchers discover chemical compounds that affect plant growth
...known as gravitropism. The researchers screened a library of 10,000 small molecules, the practice is known as chemical genomics, to identify those that could positively or negatively affect gravity's effect on plant growth, which is closely linked to the movement of proteins through plant cell membranes, a ...Consortium to create comprehensive tools for uncovering the functions of human, mouse genes
...ublic-private consortium to create a comprehensive library of gene inhibitors to be made available to the ent...sed on the method of RNA interference (RNAi), this library will give scientists worldwide the tools to knock down expression of virtually all human and mouse g...Children's Hospital & Research Ctr. at Oakland's DNA library helps to map the sex chromosome
...dren's Hospital & Research Center at Oakland's DNA library was used to duplicate strands of DNA for an intern...ational scientists map the X chromosome. "Our DNA library has become a major resource for ongoing global research in the genetics of human diseases," said Pie...Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
...t shape and arrangement," says Naviaux. "We want a library of spectra from different cell types and their cancers." Aiding stem cell research Of further interest is that the biocavity laser may be applied not only to identifying the spectra associated with cancer cells but also those associated with stem ...