Tag: "library" at biology news
Protein protects kidneys from damage caused by chronic renal disease and injury
...scovered the protein by accident while searching a library
of DNA clones involved in embryonic kidney development. "We were looking for DNA sequences with cysteine-rich domains, because we knew they were important in BMP signal suppression," Dressler says. "But as we worked with KCP, we realized it's not a s...
Unique library of plant genes germinates, takes root at UNC
...day, its developers say. Named Phytome, the unique library
is a compilation of voluminous genetic data on 39 ...y; Dihui Lu, a graduate student in information and library
science; and computer programmer Jason Phillips. The National Science Foundation is supporting the p...
Automated imaging screen reveals promising drug candidates
...process of drug discovery. But synthesizing a vast library
of compounds is just the first step in the histori...effect on a target. In addition to an ever-growing library
of candidate therapeutic compounds, advances in genome analysis have produced a growing list of pote...
Lewis C. Cantley, Ph.D., receives Pezcoller-AACR International Award for Cancer Research
...Cantley's laboratory developed an oriented peptide library
approach that has revealed the structural basis for regulated interaction of signaling proteins and has also led to a bioinformatics approach for predicting signaling pathways on the basis of gene sequences. He is currently exploring the role of PI3K...
A kiss that binds
...loss of FMRP function. They first screened an RNA library
to identify what RNA motif is recognized by the KH2 domain. They found that the KH2 domain of FMRP recognizes a loop-loop pseudoknot, or "kissing complex" structure in the RNA, and that this recognition is abrogated by the isoleucine to asparagine m...
Water research initiatives at UW-Madison
...otics and endocrine disruptors in water An online library
for state water resources WISCONSIN BUFFER INITI...ATER BOOKS FLOW THROUGHOUT WISCONSIN A UW-Madison library
specializing in water-related information has opened doors to all Wisconsin residents. Wisconsin's W...
Researcher gets NSF grant to create mutant maize lines
... the only resource of its kind, a sequence-indexed library
that allows researchers to do a database search for a DNA sequence and identify a single line of maize with a single disruption in the genome," says Brutnell, who notes that the project could expand the understanding of the functions of about 20 perc...
Researchers map 'circuitry' of yeast genes using technique that could be applied to humans
... their technique to take advantage of an expanding library
of interactions of yeast genes. Discovering such interactions has been made possible by a new type of automated experiment in which yeast strains with one harmless mutation are mated with an array of other strains, each carrying a different harmless ...
Scientists identify genes responsible for 'black rot' disease in vegetables
...then screened an Xcc transposon insertional mutant library
in its host plant (cabbage). They screened a total of 16,512 Xcc mutants on individual cabbage plants and, of these, 172 proved to be non-pathogenic. Upon further characterization of the 172 non-pathogenic mutants, the researchers came up with a no...
New plant DNA libraries provides massive boost to world's plant researchers
...a far wider range than is available from other DNA library
services. Secondly, the Warwick researchers have b... used in the treatment of a number of cancers. The library
also includes: Apple, Banana, Foxglove, Mint, Olive, Orange, Pineapple, Evening Primrose, Strawberry...
Fragment of yellow fever virus may hold key to safer vaccine
... molecular techniques, the researchers generated a library
of the millions of specialized antibodies that made up their immune repertoires. Then they screened the libraries with a vaccine strain of yellow fever. Four of the antibodies neutralized yellow fever. Genetic analysis showed they all homed in on on...
NIH awards $11.9 M to The Burnham Institute to establish the San Diego Chemical Screening Center
...reening network, the Burnham will have access to a library
of 2 million compounds, which will be individually...plementation of screening assays, robotic chemical library
screening, bioinformatics and data management will be undertaken at Burnham. Participants in the "S...
Scientists construct a physical map of the Drosophila buzzatii genome
...investigation involved two steps. First, a genomic library
was produced. This library
comprises more than 18.000 random fragments of the fly's genome inserted within bacterial cells. Eac...
Hunt for human genes involved in cell division under way
...NAs, Ambion Europe, Ltd., to produce a genome-wide library
for this project," says Dr. Jan Ellenberg, EMBL Gr...gene. EMBL chose Ambion as a supplier of the siRNA library
because its library
could be tailored to the most up-to-date list of human target genes a list prov...
Scientists discover that three molecules may be developed into new Alzheimer's drugs
...hosphorylated by the enzyme. They then performed a library
search of small molecules (58,000 of them) in an attempt to find those that would prevent phosphorylation. Small molecules are preferred because they are more easily used as a drug since they can get through the body and into cells. It is also import...
'Achilles' heel' of the herpes virus possibly found
...on by human herpes virus. They searched the genome library
to find genes essential to HSV infection, isolated... research team members in working with the genomic library
and culture of human and pig cells, especially U-M doctorate graduate Aleida Perez and postdoctoral ...
Using nanoparticles, in vivo gene therapy activates brain stem cells
...of which allow for the development of an extensive library
of tailored nanoparticles to target gene therapies for different tissues and cell types. A key advantage of the UB team's nanoparticle is its surface functionality, which allows it to be targeted to specific cells, explained Dhruba J. Bharali...
Fire fighters, managers use new software to estimate fire hazard; air pollution levels
...west Research Station. The FCCS is based on a data library
of nearly 250 fuelbeds. "Each fuelbed is a unique description of fuel from the ground to the canopy," says Roger Ottmar, a research forester and member of the FCCS development team. "This is the first time anyone has developed a system to create and...
Novel plague virulence factor identified
...lethal infection." The researchers then screened a library
of almost 1,000 Y. pestis mutants and found that six virulence factors are crucial for the bacterium to have full virulence. Of the six virulence factors, three are also required for infections in mammals. One of these factors is similar to an export...
Harmless virus may hold key to more effective HIV drug discovery
... study, Weiss and Olszewski first created one such library
by attaching the Nef protein onto the bacteriophag...ibrary, which they call an allelome, with a second library
of small-molecule compounds in order to identify the specific compounds that could target the entire...
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