JCI table of contents: August 1, 2007
...ts in red blood cells dramatically decreases their lifespan and is associated with anemia. Little was known ab... it is therefore probable that Foxo3 regulates the lifespan of these cells. In the study, Saghi Ghaffari and colleagues from the Mount Sinai School of Medicin...UB scientist discovers novel iron-copper alliance
... medical condition that affects the production and lifespan of red blood cells, such as chronic infection, chronic immune activation resulting in inflammation, or malignancy. In collaboration with Dr. Zihua Hu, Ph.D., a computational scientist at UBs New York State Center of Excellence in Bioinformatics a...New clue into how diet and exercise enhance longevity
...g clues, White said, The idea that insulin reduces lifespan is difficult to reconcile with decades of clinical...s lower Irs2 activity, which weve linked to longer lifespan in the mouse. White and his colleagues are planning their next studies to better understand how hea...Lipoic acid explored as anti-aging compound
...id, is to address issues of "healthspan," not just lifespan meaning the ability to live a long life with comparatively good health and vigor, free of degenerative disease, until very near death. The best mechanisms to accomplish that, scientists say, have everything to do with diet, exercise, healthy lifesty...Vitamin extends life in yeast, Dartmouth Medical School researchers find
...rtmouth discovery that a cousin of niacin prolongs lifespan in yeast brings the tantalizing possibility a step...y 4 issue of Cell, shows how a new vitamin extends lifespan in yeast cells, much like calorie restriction does in animals. It could pave the way for developing...Salk researchers discover first gene that specifically links calorie restriction to longevity
... a diet verging on the brink of starvation extends lifespan has remained elusive. Now, researchers at the Salk Institute for Biological Studies have cracked open the black box of how persistent hunger promotes long life and identified a critical gene that specifically links calorie restriction (CR) to long...Study shows food preparation may play a bigger role in chronic disease than was previously thought
...prised of the same calories and fat, increased the lifespan of animals when compared with animals fed their usual diet. At the moment, changing ones approaches to cooking is the only defense against excessive AGE consumption. There is no routine clinical test to inform individuals of their blood or dietary...ACS News Service Weekly PressPac -- April 18, 2007
...e restriction as a proven method for extending the lifespan of animals. Those studies, however, have not explained how calorie restriction works. The new study aimed at improving knowledge of the metabolic effects of caloric restriction suggests that some of the important beneficial changes may relate to th...New genetic biomarkers could predict coronary heart disease
...Telomeres are essential regulators of the cellular lifespan and chromosome integrity, however it has recently been shown that telomeres may also play a role in complex genetic disorders such as hypertension and diabetes....Novel strategies for healthy aging
...sing amounts of the enzyme they have shortened the lifespan of the nematodes. Professor Thornalley will present the results at the Society for Experimental Biologys Annual Main Meeting on Sunday 1st April. "This work shows for the first time that this enzyme also protects proteins against damage by oxidati...Meat and two neutrons -- the key to a longer life
...icates that this approach can potentially increase lifespan without adverse side effects. If this is borne out...used routinely. Previous successes in extending lifespan have involved withdrawing food to the point of near starvation, a process called caloric restriction...Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease
...d,well-being and motor function was preserved, and lifespan was extendedby >70%. The researchers discove...ith asmaller burden of material to metabolize. The lifespan of the micedoubled. (Neither treatment could work as effectively on its own. Infact, the effect was ...The social life of honeybees coordinated by a single gene
...al jelly they feed larvae. It can also prolong the lifespan of both workers and the queen by reducing oxidativ...f a subset of bees and compared their behavior and lifespan to a control group. (The control group also received a dsRNA treatment designed to mimic the stress ...Fruit flies may pave way to new treatments for age-related heart disease
...ction and heart physiology, andthanks to the short lifespan of Drosophila can look at the effects of aging, which is much harder to do in mammals with a relatively long lifespan. "Theres an amazing conservation of genes between flies and humans," Bodmer said. "We can now look at how heart function ages in ...The last wild hunt -- Deep-sea fisheries scrape bottom of the sea
...reproduce many times. Anything that shortens their lifespan defeats their primary way of surviving." Ecosystem Impacts Ancient deep-sea corals suffer collateral damage from bottom trawlers. "In some places skippers have replaced their nets with chains, to take out the corals so they don't tear the nets. T...Longevity by a nose (or odorant receptor)
...n. Moreover, the fact that reduced calories extend lifespan seems counterintuitive. However, said Pletcher, ...ed, said Libert. There was as much as a 57 percent lifespan extension. Most fruit flies live about 60 days. These lived longer than 80. The researchers also ...Researchers find link between food odors and lifespan in fruit flies
...es that restricted dietary intake can increase the lifespan of many species, but the mechanism that causes thi...on report that exposure to food odors can modulate lifespan and partially reverse the longevity-extending effects of dietary restriction in fruit flies. "Not o...Buildup of damaged DNA in cells drives aging
...d, according to the authors. The first is that our lifespan and how well we age is determined by the genes inherited from our parents. The second is that lifespan and fitness in old age is determined by how much damage we incur over our lifetime. "Our study su...Blame our evolutionary risk of cancer on body mass
A key enzyme that cuts short our cellular lifespan in an effort to thwart cancer has now been linked .... But while most scientists believed an organism's lifespan determined whether it was at a higher risk of cancer, Gorbunova has revealed evidence that it is not...Reduced body temperature extends lifespan in study from the Scripps Research Institute
"Our study shows it is possible to increase lifespan in mice by modest but prolonged lowering of core b...t Scripps Research who led the study. "This longer lifespan was attained independent of calorie restriction." Prior to this study, researchers had known that ...