Bone marrow may be source of new egg-cell generation in adult mammals
...nsplantation persisted for the normal reproductive lifespan of female mice. If germline stem cells in the bone marrow were the source of new oocytes, some kind of intermediate cells must travel through the bloodstream to the ovaries. To search for these potential germline progenitor cells, the investigators ...Researchers identify new genes that regulate aging
... them increases lifespan. For example, the worm's lifespan doubles when one gene is prohibited from working properly, and inhibition of another gene increases the length of life by 20%. The genes discovered affect a wide variety of activities, including insulin signaling, metabolism, and dietary regulatio...Fluorescing lab worms signal longer life spans, reports CU-Boulder team
...ble their life span -- the first evidence that the lifespan of an animal could be increased by genetic alteration. Since then, researchers around the world have been tinkering with proteins and genes of C. elegans in attempts to understand more about how life span can be increased. Although interventions in...UF study finds cell mutations that lead to apoptosis may contribute to aging in mammals
...he study. He estimated that average maximum human lifespan could be increased from the current 70 years to more than 100 years with exercise and a proper diet. "All the therapies have been targeted to reduce the free radical production in the mitochondria, and now it looks like that doesn't make complete se...Women feel more pain than men, research shows
...nce a greater number of pain episodes across their lifespan than men, in more bodily areas and with greater frequency. "Unfortunately all too often the differences between males and females are not considered in pain research or practice, and instead are either ignored or statistically averaged." There remain...UQ leads $10m study to fight dengue
...ational team of scientists who hope to shorten the lifespan of mosquitoes that carry the deadly dengue virus. "This project, if successful, has the potential to dramatically improve the lives of people living in dengue affected regions of Australia and the rest of the world," Professor O'Neill said. "We hav...Antibiotics help combat dangerous tropical disease
...uchereria bancrofti. Adult wuchereria worms have a lifespan of up to five years. During this time they produce...t Professor Achim Hrauf explains. 'Due to the long lifespan of the wuchereria worms, therapy lasts several years, during which time the symptoms continue to per...Purdue scientists may have found key to halting spinal cord damage
... at least a week. Because acrolein has such a long lifespan and is so toxic, we theorize that it is primarily responsible for the secondary damage that keeps injured spines from healing." Acrolein's involvement with other conditions suggests that it could be the key to fighting a number of diseases, Shi said....Scientists report tissue engineering success
.... One obstacle to generating tissue is the limited lifespan of adult human cells. Human cells have inbuilt tim..., USA) and colleagues tested whether extending the lifespan of blood vessel cells could help generate blood vessels for elderly patients. The researchers took a...Most common lung cancers may begin in newly discovered cells
...ny times. Likewise, stem cells can divide over the lifespan of the organism. Also, tumors are very heterogeneous, composed of many different cells, and stem cells can give rise to different types of cells." The researchers do not know if the stem cells play a role in more established tumors, but other scienti...Researchers extend mouse lifespan by protecting against free radicals
...nters have found a way to significantly extend the lifespan of mice while reducing the impact of the aging pro...Scientists have previously been able to extend the lifespan of mice in lab experiments by managing their diets and reducing their caloric intake. Another method...Protein protects kidneys from damage caused by chronic renal disease and injury
...surprised to find they were fertile, with a normal lifespan and no obvious abnormalities. "Bone morphogenetic proteins have a definite developmental function. If you knock-out BMP7, the kidneys stop developing about 14 days after fertilization," Dressler says. "But KCP doesn't appear to affect embryonic dev...White blood cell 'waste disposal' system plays critical regulatory role
...mful foreign substances. Neutrophils have a short lifespan and often die via a programmed cell death pathway called apoptosis within a matter of hours. Dying neutrophils are recognized and ingested by cells in the body tissues called phagocytes. Although the specific mechanisms that regulate the proper rati...Father of regenerative medicine pushes M prize over the $1 million mark
...the scientific research group that can most extend lifespan in a single mouse. The second, the Rejuvenation Prize, will be awarded to the scientist who can most sharply retard aging in a mouse, using interventions that are not initiated until middle age. "That's good news for those of us who are already aliv...Future diabetes drugs may target new protein interaction
...ill don't know whether sirtuin1's activity affects lifespan in mammals." There is a precarious anecdotal link,...nt, knowing for sure whether sirtuin1 helps extend lifespan (an organism issue) or is merely involved in cellular aging (a cell-by-cell issue) in mammals will t...Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
...nts. Some patients require no treatment and have a lifespan of more than 20 years after diagnosis. Since the d...cases, patients do require chemotherapy and have a lifespan of only about six to eight years after diagnosis despite treatment. Scientists, including Drs. Chior...The secret to longevity in tubeworms
With an incredible lifespan of up to 250 years the deep sea tube worm, Lamell...s return of sulfate, the model predicts an average lifespan of only 39 years in a colony of 1,000 individuals; with it, survival increases to over 250 years, ma...Sexual cooperation: Mating increases longevity in ant queens
...ng, but they can be very harmful to females, whose lifespan and future reproductive output can be drastically ... actually benefit from mating by gaining increased lifespan and reproductive success, living longer irrespective of whether males could transfer viable sperm or...Opposing fat metabolism pathways triggered by a single gene
...hers discovered that when nhr-49 was absent, the lifespan of the nematode was reduced by more than 50%, and the animal displayed numerous gross abnormalities in the gut and gonad. This was accompanied by unusually high fat content in the larvae. They further showed that deletion of nhr-49 changed express......to 6.5 years in a fish species that has a maximum lifespan of about 50 years. Soon after, many fisheries were in serious decline. Genetic studies by OSU researcher Michael Banks and his graduate students have also shown that there are many unique fishery stocks up and down the coast that do not interbreed, ...