Green tea polyphenols thwart prostate cancer development at multiple levels
...n of cell growth via the IGF-1 axis coincides with limited production or phosphorylation of key cell survival proteins, including PI3K, Akt and Erk1/2, the research indicated. The PI3K molecular pathway in cells, which includes Akt and Erk1/2, works to promote cell survival, rather than programmed cell death...JCI table of contents, December 1 2004
... that the beneficial effects of treatment were not limited to early stages of the disease when behavioral cha...e, suggesting that this class of drug might not be limited to treatment in the initial phases of disease. Further studies will determine how long improvements ...Carnegie Mellon scientist develops way to deliver promising genetic tool into living cells
...ells, these methods remain largely ineffective and limited to small-scale experimental setups, according to Ly. "We found that our modified PNAs were not only taken up by cells, but they also were localized predominantly in the cell nucleus, a specialized compartment in the cell where messenger RNAs are made...Scientists discover key egg enzyme for blocking sperm entry after fertilization
... not well understood. The respiratory burst is not limited to eggs; other cells of the body can also generate peroxide. White blood cells produce it in response to an infection, but its harmful effects often kill the cell producing it and, as a result, these cells must be constantly replaced. Dr. Gary M. We...Efforts to clone primates move forward
...ough therapeutic cloning." In therapeutic cloning, limited cell division is induced in an unfertilized egg cell to produce embryonic stem cells. In reproductive cloning, an egg cell with a donor nucleus is transferred into a living surrogate female in an attempt to make a successful pregnancy. Stem cells are...Study reveals developing countries with recipe for thriving health biotech industries
...ield. Although Cuba has had success, limited access to foreign investment in the capitalistic w...ll as South Africa HIV/AIDS. "With limited resources and underdeveloped private sectors, targeting specific areas that fit both their needs and...Chicken genomic sequence yields insight into vertebrate evolution
...in mammals, studies in lower vertebrates have been limited until now. Martina Paulsen, Ph.D., and her colleagues at the Universitt des Saarlandes in Germany, compared the Beckwith Wiedemann Syndrome (BWS) imprinted gene cluster in chickens to that in mammals, pufferfish, and zebraf...New approach studying protein structure could advance drug development
...strial pipeline could be set up that would only be limited by a few minutes per protein-small molecule intera...crystal structures are tough to attain, and only a limited number of proteins have documented crystal structures of the protein with and without a ligand prese...New tuberculosis antibiotic may shorten treatment time, fight drug-resistant strains
.... Of course we caution that we have only studied a limited number of people for limited amount of time, so further research is necessary," Andries said. Phase 2 clinical trials to measure ...New pathway identified in angiogenesis
...pies engineered to block the process have had only limited success. Additional investigators from Ohio State who worked on the study include Michelle Galloway, Yijie Wang and David Cohn. ...New model of rare childhood blindness holds promise for testing preventive therapies
...especially the case with LCA. Diseases with such a limited patient population discourage the expensive commercial research and development needed to find an effective treatment for it, according to Michael A. Dyer, Ph.D., assistant member of St. Jude Developmental Neurobiology. Dyer is first author of the MB...INEEL-designed system assists army with chemical weapon destruction
... who wear as much as three sets of gloves and have limited mobility. The U.S. Army Non-Stockpile Chemical Materiel Program has provided safe storage and monitoring of non-stockpile chemical weapons for more than 45 years. They lead the nation in the development and use of advanced technology to safely elimi...Latest census finds more American pika populations disappear as climate warms
...g essentially on high-elevation islands and having limited dispersal capability means that American pikas in these regions have little option for refuge from the pressures of climate change because migration across low-elevation valleys represents an incalculably high risk for them and perhaps an impossibil...Potent anticancer drug increases function of axons in mouse model of neurodegeneration
...e approved for treating patients with cancer and a limited number of other diseases, it might be possible to move quickly to clinical trials of these types of compounds, say the researchers. However, it will be necessary to find microtubule-binding drugs that can cross the blood-brain barrier, where they can...Immune system contributes to evolution of a new fluorescent protein
...ng, and the size of the library of mutant genes is limited by the efficiency with which we can introduce at m...ful in directed protein evolution. "It will not be limited to the particular class of proteins that we studied," he said. "It does require that you have a robu...'Jumping gene' helps explain immune system's abilities
... la carte approach provides great diversity from a limited number of choices, whether in the immune system or in a cafeteria. For example, at a cafeteria, one diner could have a meal of mashed potatoes, broccoli and a pork chop, and another French fries, salad and a hamburger, and so on through all the possi...New technique for tracking gene regulators
...he pieces to their compliments on microarrays, are limited by the size of genome they can analyze. Dunn's team has come up with a technique to determine the positions of these 500-to-1,500-base-long pieces on an entire genome -- even one as large as the human genome -- relatively quickly and in very large nu...Fox Chase Cancer Center scientists discover key proteins linked to aging and cancer
...od and old age." Most normal human cells undergo a limited number of cell divisions but are eventually arrested, either through final differentiation or senescence. Differentiation is the process whereby a proliferating cell stops growing and develops into a cell with a specific function, such as a liver ce...A key signaling molecule in osteoarthritis is identified
...he initiation and progression of osteoarthritis is limited since current research efforts are mostly focused on either risk factors for the disease or biochemical events in cartilages of joints at later stages of the disease," explains Dr. Li. "However, the similar clinical outcomes in different forms of ost......ient and appropriate donor fetal brain tissue have limited the application of this therapy. These researchers previously demonstrated that mouse embryonic stem cells can differentiate into neurons when cultured under specific conditions. These same culture conditions, technically simple and efficient, we...