American Chemical Society's Weekly PressPac -- Aug. 8, 2007
...oliferation of instruments alongside manufacturing lines and in battle zones, office buildings, and refineries, it just might be feasible for a consumer to walk into Home Depot someday and buy a device that today only a scientist or quality control expert would want to have, the article concludes. ARTICL...Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
...tations in hundreds of MM patient samples and cell lines to identify mutations that impact NF-κB activation. Dr. Louis M. Staudt from the National Cancer Institute led a research group who revealed the importance of both the classical and alternative NF-κB pathways in MM pathogenesis. Most MM p...Newly created cancer stem cells could aid breast cancer research
...s to get a tumor when working with the cancer cell lines routinely used in the laboratory. In the process of making a model that reflects a tumor type common in patients, I created tumor-initiating cells, Ince explains. That was a complete surprise. This work could provide a boon to researchers who stu...UCLA scientists produce functioning neurons from human embryonic stem cells
...in Suns study showed that two embryonic stem cells lines derived in similar manners, and therefore expected...me techniques to prod the two embryonic stem cells lines to differentiate, Sun found that one line had a bias to become neurons that are found in the forebra...Story tips from the US Department of Energy's Oak Ridge National Laboratory, August 2007
...atory research has aided in development of two new lines of wireless sensor products targeted at manufacturers by industry heavyweights Honeywell and General Electric. The instrument offeringsRF ValProbe by GE and OneWireless by Honeywellrepresent a new generation of wireless technology that taps industry-...Not all embryonic stem cell lines are created equal
...s have found that not all embryonic stem (ES) cell lines are equal. In comparing neurons generated from two...ns. However, because different embryonic stem cell lines were derived under diverse conditions, the possibility existed that cell lines would produce neurons...Discredited Korean embryonic stem cells' true origins revealed
...nesis and genetic screening to identify those cell lines that are going to be most helpful," Daley says. Parthenogenetic embryonic stem cells do not obviate the need to also create embryonic stem cells through nuclear transfer or from human embryos, he adds. "Each of the strategies has its own applicatio...U-M researchers find family of 'on switches' that cause prostate cancer
... percent to 70 percent of the prostate cancer cell lines the researchers looked at. The genes involved are all controlled by a different mechanism. For example, four of the genes are regulated by androgen, a male sex hormone known to fuel prostate cancer. Androgen deprivation is a common therapy for prosta...Females more prone to brain damage from alcohol abuse
...le to identify gene expression differences between lines of mice that are genetically selected for severe alcohol withdrawal compared with mice that are resistant to alcohol withdrawal," Wiren said. "I thought there would be a difference between the genders, but I didn't think it would be the most importan...Bumblebees make bee line for gardens, National Bumblebee Nest Survey finds
...ts (36 nests per ha), followed by hedgerows, fence lines and woodland edges (20-37 nests/ha). Nest densities were lower in woodland and grassland (11-15 nests/ha). Until now, little has been known about which habitats are best for bumblebee nests. According to the study's lead author, Dr Juliet Osborne o...Assessing levies for by-catch could fund conservation measures
Fishing industry lines accidentally catch so many seabirds and turtles that their populations are being threatened. One solution offered by a Cornell researcher and an Australian government scientist is to assess fines when threatened species are caught and killed. That mo...JCI table of contents: July 12, 2007
...t ER-alphanegative primary breast cancers and cell lines showed increased levels and/or activity of the protein Src, which cooperates with estrogen to activate ER-alpha breakdown via proteolysis. In line with this finding, Src inhibition was shown to impair estrogen-stimulated ER-alpha proteolysis. The dat...Antibody retards growth and induces death in liver cancer cells
...Medicine, obtained rat and human liver cancer cell lines and analyzed them for level of expression of an RT...levels of PDGFR in rat and human liver cancer cell lines as compared to normal cells in culture. Dr. Mongas group then treated human and mouse liver cance...News tips from the Journal of Neuroscience
...wed an angular path that corresponded to the force lines in the electrical field. Time-varying fields caused the worms to reverse and turn. For example, steady rotation of the field caused worms to crawl in perfect circles for hours, perhaps similar to rotary traffic during a Boston rush hour. Laser ablati...Biodesign Institute leads innovative project to prevent cancer
...ragments, or peptides, found in breast cancer cell lines and primary tumors. The key is that these peptides have to trigger an immune response against breast tumors but not in normal cells, said Johnston. Johnston knows demonstrating their approach will be a significant challenge. But he has been encour...Other highlights from the July 10 JNCI
...olleagues studied several human neuroblastoma cell lines to identify genes that cause drug resistance. They found that HDAC1 was overexpressed in multidrug-resistant cells, compared with drug-sensitive cells. Blocking HDAC1 made the cells more sensitive to chemotherapy drugs that treat neuroblastoma. ...Chickens also orient themselves by the Earth's magnetic field
...agnetic sensor showed them the course of the field lines of the Earths magnetic field. This produces an inc...ng between pole-wards (the side on which the field lines incline downwards) and equator-wards (the side on which they incline upwards). The inbuilt compass i...Study: Donated embryos could result in more than 2,000 new embryonic stem cell lines
...t of 2001, less than two dozen embryonic stem cell lines were made eligible for federal research funding. Most scientists now agree that the eligible lines have proven inadequate in number and unsafe for transnational research. Until recently, the best est...New tumor markers -- 'Spot the differences'
... here we do not have easy drawings with just a few lines as in a puzzle (Figure A). Instead, we compare complex images with hundreds of thousands of different intensity points. In our study we identified a total of 116 messages that were over-expressed in cancerous cells. These findings reveal some of th......icy limits such funding to fewer than 20 stem cell lines that had been created when the president first announced U.S. policy in 2001. "Our concern is that this action has the potential to delay development of important new therapies by cutting off a promising avenue of research," said Alan I. Leshner, the...