UCI launches effort to develop patient-specific stem cell lines
...team today launched a project to develop stem cell lines that genetically match human patients. These lines would allow scientists to better study conditions ranging from diabetes to Parkinsons disease, and t...Scientists develope a new model of artificial canine skin
...will allow, therefore, the carrying out of various lines of research related to skin biology and pathology without the need to use live animals. The basic structure of skin consists of an external layer, the epidermis, and an internal layer, the dermis, separated by a basal membrane. A study of the inter...'Personality-gene' makes songbirds curious
... of the birds. This is first shown in two breeding lines of great tits, which the researchers had selected over four generations according to their level of curiosity (a low and a high curiosity line). The scientists assessed the curiosity of the birds in a test which shows similarities to the traditional ...Breast cancer milieu -- Progression, tamoxifen sensitivity, and DNA reversion
...normal breast cells but lost in breast cancer cell lines and invasive breast tumors. As further confirmation of Fibulin-2s anti-invasion effect, reintroduction of the protein into Fibulin-2-negative breast cancer cells resulted in decreased cell migration and invasion in vitro. Fibulin-2 is a known comp...An electroacoustic path to custom-made gene chips
...nap, only one of the four ejectors fires. Supply lines from four central reservoirs refill the injectors after each snap. Construction of quartet array system, described as a "nozzleless, heatless, lensless" machine is a complex process Kim and his former students, Jae Wan Kwon, now of the University o...Deactivating protein may protect nerve fibers in MS
...reakthroughs do not come from the more traditional lines of inquiry," he said. "What I appreciate about our relationship with OHSU is that there seems to be a sense of urgency about these projects. And it's been beneficial for us to develop a more personal relationship with the researchers. That way it bec...Can a taste for poison drive speciation?
...sly proscribed plant. The researchers generated lines of "knock-out" flies that lacked either Obp57e genes, adjacent Obp57d genes, or both (called double knock-outs). Flies lacking just one of the genes avoided hexanoic acid-laden traps, whereas females missing both genes flocked to them. But the most i...Knocking out survival protein could aid leukemia treatment
...ing cancer cells from 17 CLL patients and ALL cell lines grown in the laboratory. The investigators placed molecules called small interfering RNA (siRNA) inside the cells and found that the tiny molecules greatly reduced the amount of the survival protein, causing many of the cells to die. The effect wa...JCI table of contents -- April 19, 2007
... indicated that triple-negative breast cancer cell lines are sensitive to exposure to the chemotherapeutic cisplatin. In the study, which appears online on April 19 in advance of publication in the May print issue of the Journal of Clinical Investigation, Leif Ellisen and colleagues show that triple-nega...Researchers identify key gene that may be a marker of breast cancer metastasis
... developed several AI-resistant breast cancer cell lines and have found that these cells are very invasive compared to AI-sensitive breast cancer cells," she explained. "Analyses of gene activity in these AI-resistant cells have shown that they express high levels of genes associated with invasiveness and...Genes and biomarkers that allow doctors to choose the right therapy for the right patient
...of 50 breast cancer cell lines. Each of these cell lines represents a single variant among the different ge...ll line and used these to identify subsets of cell lines that represent the subtypes observed in analyses of primary tumors. By correlating the responses ...Oncolytics Biotech Inc., research collaborators demonstrate reovirus/gemcitabine
...rs found that treatment of human colon cancer cell lines with the combination of REOLYSIN and gemcitabine resulted in both in vitro and in vivo synergy. There was no toxicity associated with the combined treatment. Tumours treated with the combination were significantly smaller (by area and weight) than ...Stem cells provide new tool for studying disease and identifying ALS drugs
...uriosity and open-mindedness for new and promising lines of research is emblematic of Project A.L.S.," added Serge Przedborski, Page and William Black Professor of Neurology, at Columbia. ...Massey researchers induce cell death in leukemia
...llel studies conducted on two established CLL cell lines provided additional preclinical evidence that bortezomib interacts synergistically with both agents to induce cell death in human CLL cells. Romidepsin and belinostat are histone deacetylase (HDAC) inhibitors. "To the best of our knowledge, this i...Progress toward a targeted therapy for a specific form of leukemia
...ombined inhibition of NOTCH1 and MYB in T-ALL cell lines is very effective. These results raise hopes that scientists will be able to develop a very effective combination therapy - in which the concentration of the toxic NOTCH1 inhibitors is reduced - for the group of patients in which MYB and NOTCH1 play ...New way to catch cancer's spread, rapid 3-D retinal imaging, more at CLEO/QELS 2007
...ed retinal scans at record speeds of up to 236,000 lines per second, a factor of 10 improvement over current OCT technology. With their technique, which uses a frequency-tunable laser to achieve fast scan speeds, they obtained a 3-D retinal image consisting of 512x512x400 volume elements of data in a human...JCI table of contents: April 12, 2007
...agues show that loss of ATM function in human cell lines with a dysfunctional FA pathway caused the cells t...olleagues show that in human myeloid leukemia cell lines the CaMKII CaMKII-gamma interacts with RAR and inhibits its function by phosphorylating RAR-alpha, t...2 heads are better than 1: 2 dysfunctional DNA repair pathways kill tumor cells
...agues show that loss of ATM function in human cell lines with a dysfunctional FA pathway caused the cells to die. The dying cells were characterized by high levels of DNA breakage, which is consistent with the fact that FA pathway proteins and ATM are important regulators of two distinct DNA repair pathway...AACR to present distinguished public service awards at 2007 Annual Meeting
...ill patients with cancer. His insistence upon open lines of communication and transparent governance and administration particularly through the NCI Cancer Bulletin and other new publications filled a vital role in keeping the public informed about the work and progress of the Institute. A nationally rec...... the heat-shock gene was consistently lower in the lines with the missing nucleotide than in the normal bacteria. What does this mean for A. pisum's ability to tolerate tough conditions? To answer that, the researchers asked whether exposing juvenile aphid hosts of Buchnera with either long or short pro...