Clinical trial for diabetic macular edema
... corresponds to the ability to read two additional lines on a reading chart. In the phase 1 study, there were no adverse events that were judged by the investigators to be related to the drug. Some patients experienced redness on the surface of the eye at the site of injection that lasted up to 72 hours. ...Notorious cancer gene may work by destroying messenger
...iu and Elizabeth Murray will use three cancer-cell lines to try to identify what messenger RNAs which will also tell them what proteins are targeted and destroyed by PMR1. That will help tell us whether Src works through PMR1 to contribute to cancer, Schoenberg says. Funding from the National Insti...Do you need sex to be a species?
...e, then asexual taxa should diverge along the same lines as sexually reproducing organisms. And if this were the case, they would expect to find genetic and morphological cohesion within independently evolving populations and divergence between them. To detect independently evolving populations, the resear...JCI table of contents: March 15, 2007
...leagues show that Nutlin-3a induces human PEL cell lines to undergo cell death by a process known as apoptosis. Nutlin-3a was found to disrupt an interaction between the KSHV protein LANA and the human proteins p53 and MDM2, releasing p53 to mediate apoptosis. As treatment with Nutlin-3a induced substantia...Researchers identify molecular basis of inflammatory bowel disease
...yer of interconnected cells, called an epithelium, lines the intestinal surface creating a barrier that prevents bacteria from crossing that border. The mechanisms that control the integrity of the epithelium and contribute to maintaining a healthy gut have remained unknown. Arianna Nenci from the group of......chrotron images reveal microscopic internal growth lines without damage to the specimen. The team found tha...sses in fossil humans. By using incremental growth lines in teeth, similar to annual rings in trees, developmental rate and time may be accurately establishe...New cell type identified in cancer development
...of the animals had lymphoma, and that several cell lines from those tumors carried a unique and provocative...nd out more about them. They selected three pCSC lines and injected them subcutaneously, intraperitoneally or intravenously into three groups of mice. The ...These legs were made for fighting
...ntly," he adds. "There are a number of independent lines of evidence suggesting that much of human violence is related to male-male competition, and this study is consistent with that." Nevertheless, male-male competition doesn't fully explain human violence, Carrier says, noting other factors such as h...UGA research shows rats are capable of reflecting on mental processes
...icated" and why. The research will also open new lines of inquiry about the underlying neural mechanisms of this ability. Reflecting on ones own mental experiences is a defining feature of human existence, and the demonstration of metacognition in rats suggests that this type of cognition may be widespre...JCI table of contents -- March 8, 2006
...ver, reducing the amount of CDX2 in human AML cell lines decreased their ability to proliferate, indicating that CDX2 has a causal role in the pathogenesis of AML. Further evidence of this was provided by the observation that mouse hematopoietic cells engineered to express CDX2 were induced to proliferate ...Survey finds emotional reactions to nanotechnology
...hnology is up for grabs. It could divide along the lines of nuclear power, global warming and other content... concept, and their opinions divide along cultural lines as they learn more about it," according to Dan M. Kahan, the Elizabeth K. Dollard Professor at Yale ...CDX2 -- A protein that promotes leukemia
...ver, reducing the amount of CDX2 in human AML cell lines decreased their ability to proliferate, indicating that CDX2 has a causal role in the pathogenesis of AML. Further evidence of this was provided by the observation that mouse hematopoietic cells engineered to express CDX2 were induced to proliferate ...Researchers find the mechanism by which cells resist chemotherapy
...eam has also observed that many breast cancer cell lines are between two to three times more sensitive to chemotherapy if they have partially inhibited the Fanconi FANCD2 gene expression. ...Lessons in wood formation from Arabidopsis
...normalities in mutant plants, but double knock-out lines of NST1 and NST3 showed a significant loss of thic... gene expression in the mutant lines, and in plant lines engineered to overexpress NST1 and NST3, showed that these transcription factors regulate the expres...News tips from the Journal of Neuroscience
...1 had abnormal auditory thresholds. Fourteen of 19 lines showed recessive inheritance patterns. The authors have thus far identified hair cell defects attributable to point mutations in four genes, all of which have been linked to deafness in humans. Human missense mutations in one gene, pejvakin produce...MIT bioengineer advances survival, promise of adult stem cells
...ow, my personal views about creating human ES cell lines changed when confronted with the reality of doing ...ed research is only allowed on certain established lines of embryonic stem cells, although a few states, including California and Connecticut, offer state fu...Unique tomatoes tops in disease-fighting antioxidants
...or this study, the researchers have pre-commercial lines of both varieties available. He conducted the study with Ohio State colleagues David Francis, an associate professor of horticulture and crop science; Steven Clinton, an associate professor of hematology and oncology and human nutrition; Nuray Unlu...AAAS honors defenders of evolution with Scientific Freedom and Responsibility Award
...d nine science teachers who have been on the front lines of the battle to prevent introduction of "intelligent design" into science classrooms as an alternative to evolution, are recipients of the 2006 AAAS Award for Scientific Freedom and Responsibility. Scott has been tireless in her efforts to offer ...