New hope for regenerative medicine
...y have several advantages over embryonic stem cell lines generated by somatic cell nuclear transfer (also known as therapeutic cloning). Normal mammalian embryos inherit one set of chromosomes from the mother, and one set from the father. Embryos that inherit both sets of chromosomes from the same paren...Winners of the 2006 AAAS Science Journalism Awards
...thquake, its policy impacts and the regional fault lines in a clear and inviting way." CHILDREN'S SCIENCE NEWS Beth Geiger Current Science "Fade to White," Jan. 6, 2006 Journalists worldwide are eligible for this award, which was established in 2005. Geiger won praise from the judges for explaining ...Fighting to keep Darwin in the classroom
...sm ammunition for our school teachers on the front lines of this ongoing battle. Today, on Darwin's 198th birthday, Springer announces plans for a new journal which will do just that. A father-and-son teama world-renowned evolutionary biologist and a highly skilled and sophisticated science high school ...Oxidative stress stimulates p38 MAPK-mediated tumor suppression
...tumorigenic potential in several human cancer cell lines that were examined. The authors suggest that it may be possible for cancer cells to escape the tumor-suppressive functions of p38-alpha by desensitizing p38-alpha to oxidative stress. Indeed, many tumor cells exhibit increased expression of GST pr...Neuronal differentiation of human neural stem cell grafts in adult rat spinal cord
...l need to repeat this work using different primary lines established from other human embryonic spinal cord cells, the necessity of using different animal models that are not immune deficient, and also the need for future studies that include behavioral analysis of the experimental animals. Citation: Yan...JCI table of contents -- February 8, 2006
...tment. Further analysis showed that different cell lines from CF patients with the W1282X mutation had dist...ing the destruction of nonsense mRNA in these cell lines increased the amount of nonsense CFTR mRNA present, making them more susceptible to the ability of g...Woven scaffolds could improve cartilage repair
...." Cartilage is a type of connective tissue that lines the ends of bones, providing cushioning and a smooth surface for their movement within the joint. Damage to cartilage is difficult to treat, the researchers said, because the tissue lacks a supply of blood, nerve and lymph and has limited capacity fo...News tips from the Journal of Neuroscience
...lation in vitro . This week, Xie et al. used cell lines to unravel the underlying mechanism. Treatment of naive human H4 neuroglioma cells with 2% isoflurane increased caspase-3 activation and decreased cell viability without affecting secreted A. In APP-overexpressing cells, however, isoflurane increased...Joslin discovers protein that causes blood vessel leakage and swelling with diabetic retinopathy
...he researchers then investigated several different lines of study and found that CA-1 increased retinal edema -- the swelling of the retina. "This is the first evidence we have of a protein causing swelling, not just leakage, in the rodent at concentrations observed in human disease," said Dr. Feener. Pe...Genes behind animal growth discovered
...trains, or oyster types, without guesswork. The lines would not be genetically modified, only screened and matched as in a dating service. The goal is efficient and sustainable domestication of oysters and other promising ocean species, mostly shellfish. Oysters already are the number one farmed aquat...Scientists map key landmarks in human genome
...cleosomal DNA was derived from several cancer cell lines including melanoma and breast cancer, as well as several normal human cell types. A critical component of the analysis involved processing the data using computational algorithms devised by Dana-Farber faculty member X. Shirley Liu, PhD, and her post...Selective marker found to indicate aggressive form of breast cancer
...researchers, but also eliminates several important lines of therapy, such as tamoxifen or Herceptin, that work well for other breast cancer subtypes. "Currently, there is no direct means of determining if a breast cancer is a basal epithelial tumor doctors only know for certain once the other forms of ...Dengue and other hemorrhagic fevers: Towards a first potential treatment
...ing viruses, such as Ebola, Marburg, or Hanta. New lines of therapeutic research against these pathologies, for which no treatment yet exists, can now be envisaged. Indeed, clinical trials on Dengue are currently in preparation....Ossur hf. acquires the Gibaud Group in France
...dic businesses in Europe." Gibaud's main product lines are braces & supports and compression therapy products. The bracing and support market in France is estimated to be valued at approximately USD 130 million. Gibaud Group is the second largest player with a market share in excess of 20%. The phlebolog...Neural stem cells lend the brain a surprising capacity for self-repair
...xpected role in maintaining the cellular wall that lines the ventricular region of the brain in which the SVZ resides. Without the normal complement of genes, that wall "disintegrated," he said, leaving holes in the brain. Surprisingly, they reported, the ventricular damage was eventually repaired. SVZ re......lled bone marrow stromal cells. The two stem cells lines probably have a common progenitor but for now scientists can only regard hematopoietic stem cells and osteoblasts as niche neighbors. But its a very close relationship, as researchers in the National Institute of Child Health & Human Development labo...Researchers create genetically matched embryonic stem cells for transplantation
...n efficient way of generating customized stem cell lines from women," says George Q. Daley, MD, PhD, senior author on the paper, who is the Associate Director of the Children's Hospital Boston Stem Cell Program and a member of the Executive Committee of the Harvard Stem Cell Institute. "It would eliminate ...A fisheye view of the deadliest breast cancer
...at overexpress RhoC. They injected both tumor cell lines into the immune-suppressed fish and watched the cancers progress over several weeks. The tumor cells homed in on blood vessels, forming tumor-like aggregates and tapping into the fishs circulatory system by inducing an angiogenic response. A separ...First biomarker for human sleepiness identified in fruit flies
...vel after sleep deprivation in different fruit fly lines genetically altered to modify their sleep drive. In one key test, amylase did not increase in a fly modified to endure sleep deprivation longer than normal flies without incurring sleep debt. When scientists kept the same mutant flies awake for exte...Chemotherapy can be more toxic to brain cells than to cancer cells and may cause brain damage
...ines, such as uterine, breast or colon cancer cell lines to the same chemotherapeutic agents. Cisplatin is ..., but has little effect on most of the cancer cell lines examined. The authors show that to kill 40-80% of cancer cells, doses that also kill 70-100% of neur...