Resistance to chemotherapy in lung cancer, optimizing flu vaccination strategies
...n from lung tumors and in several lung cancer cell lines and found mutations in KEAP1 in half the cell lines and a fifth of the tumor samples. They also found that about half of the samples had lost one copy o...Antibiotic inhibits cancer gene activity
... Siomycin A must now be tested against other cell lines in the laboratory and in preliminary animal experiments before human trials could be planned. Only a tiny fraction of promising candidate drugs enter clinical trials, and few of those are ever approved. Gartel said the participation of the late Rob...'1491' wins 2006 Best Book Award from the National Academies
...he opportunity to compete for grants to pursue new lines of cross-disciplinary research. The winners of the communication awards were selected by a committee of 10 judges: Barbara J. Culliton (committee chair and member, Institute of Medicine), journalist, former deputy editor, Nature, and former news ...Scientists use gene signatures to match cancer and other diseases with potentially effective drugs
...ore sensitive to glucocorticoids, and in some cell lines it appears that it does," he said, adding that a c...ey are proposing a large-scale effort -- along the lines of the Human Genome Project -- to map connections among genes and diseases to accelerate the develop...What animals can tell us about hemorrhage, organ transplants and aging
...e. There are plenty of fresh and interesting story lines you can develop by going through the program or by calling The American Physiological Society. Go to http://www.the-aps.org/meetings/aps/vabeach/index.htm and click on "Week at a glance" for the full Comparative Physiology program. Check out "Con...Watching DNA repair in real time
...d forming a filament. A piece of complementary DNA lines up along side it, and pieces of DNA can be swapped in to repair gaps in the original strand. A similar protein, called Rad51, does the same job in humans. "How RecA and Rad51 assemble into filaments determines the outcome of DNA repair, but very li...HHMI hosts international scientists at Janelia Farm Research Campus
...nd reappear, more virulent than ever. On the front lines of the recent outbreak of drug-resistant TB in South Africa, she will report on her research into the molecular mechanisms that TB bacteria use to remain dormant in the body and then reactivate. Karel Svoboda, a group leader at Janelia Farm, wil...Republic of Congo announces two massive protected areas
...grass and wooded savanna patches separated by fine lines of dense gallery forest, along with a multitude of small lakes and river valleys. The south and west of the new park supports an intact block of Chaillu forest and the Ougue River basin along which a series of important natural forest clearings are ...'Telomere' expert Carol Greider shares 2006 Albert Lasker Award for Basic Medical Research
...work, which has shown that by pursuing interesting lines of research, devising clever experiments to test new ideas, and working with great persistence, one can be extremely successful." Education and Career Path Carol Greider, 45, grew up in Davis, Calif., where her father was a physicist at the Univers...Poplar DNA code cracked -- new possibilities for sustainable energy
...volution of the poplar. Scientists know that the lines of descent of the poplar and Arabidopsis began to evolve in different directions some 100 to 120 million years ago. The researchers have determined that a doubling of a large part of the poplar's genes has occurred twice in history. One of these dupl...Existing vaccine facilities can handle flu pandemic
...of hen eggs than it would to grow up existing cell lines from frozen vials, Lash said. While cell culture has a lower yield than egg culture, there is more existing capacity for cell culture than for inoculating and processing eggs. "Based on existing dosages, we'd have enough doses in about 3 to 4 month...Using microbes to fuel the US hydrogen economy
...ilities, as eliminating all oxygen from production lines could be very expensive. "Our research provides the first evidence that bacteria can efficiently produce hydrogen gas when oxygen is present." In collaboration with Paul King, a scientist at the National Renewable Energy Laboratory, the Brookhaven ...Animal physiology conference sheds light on human physiology
...a. There are plenty of fresh and interesting story lines you can develop, breaking away from the cookie cutter stories that everybody else is covering. Comparative physiology is the study of all kinds of animals, finding general principles that may apply to humans, too. Working with frogs, snakes, squirre...Using nature's most primitive anti-viral defense system to find new approaches to cancer research
...ow to compare those to similar genes in human cell lines to help him understand why some cancer cells invade and spread to other parts of the body." Derek Napier, AICR's Chief Executive says the grant awarded to Dr Baum and worth 136,000 has been given in line with the charity's policy of funding the mos...Plants give up answers in the war on bacteria
...hed light on the behavior of one the plant's first lines of defense against disease. Pores called stomata are like tiny mouths that open and close during photosynthesis, exchanging gases. In sunshine, the stomata open. In darkness, they close to conserve water. It has been assumed that these tiny ports ...NIH launches Knockout Mouse Project
...entific teamwork at its best." Knockout mice are lines of mice in which specific genes have been complete...stematically create mouse embryonic stem (ES) cell lines in which 5,000 genes have been knocked out by gene targeting. The VelociGene division of Regeneron, ...News tips from the Journal of Neuroscience
...nerated >2500 transposable P-element insertion lines in which the yeast upstream activating sequence pr...omly inserted into the fly genome. After selecting lines with altered synapse morphology, they identified four in which the P-element insertion was positione...Dipstick test for meningitis culprits
...luid. After several minutes, the appearance of red lines on the dipsticks shows whether one of the four groups of meningococcus is present, and if so, which one. The new dipstick test for meningococcal meningitis represents a major advance for health-care workers in remote locations affected by meningit......earchers evaluate two nearly genetically identical lines of California rice: the original submergence intol...e. A careful comparison of the two California rice lines showed that in the submergence tolerant line the rice plants orchestrate a number of cellular respon...