Body's biological clock found to affect cardiac rhythm patterns in healthy adults
...rresponding to 10 a.m., the time of day most often linked to adverse cardiac events in individuals with hear...ut, the researchers hypothesized, they can also be linked to an internal body clock, the endogenous circadian pacemaker that controls much of our physiology, ...Potent anticancer drug increases function of axons in mouse model of neurodegeneration
...d in this case impaired axonal transport, which is linked to many neurodegenerative diseases. Impaired axonal transport of proteins and other cargoes needed to maintain synapses can cause nerve cell loss with subsequent dementia, parkinsonism or weakened motor skills in peripheral muscles, and later muscle ...Fundamental finding yields insight into stem cells, cancer; opens door to drug discovery
...eam found that the protein beta-arrestin2, earlier linked to a variety of inhibitory functions, also plays a...restin2 protein, exhibited characteristics earlier linked to defects in the Hh signaling pathway, including curved bodies, underdeveloped heads and abnormal m...University of Chicago researchers discovered that humans are a 'privileged' evolutionary lineage
...the evolution of the human brain more likely to be linked to diseases of the human brain? What happens when something goes wrong in these genes? Does it create neurological and psychiatric problems such as mental retardation or addiction? Could these genes contribute to IQ differences in humans? Do people w...Federal/private partners launch resource for diabetic kidney disease gene studies
...abetes. "GoKinD will help us tease out genes linked to kidney disease versus those that are primarily ...disease or improve treatment. Studies have already linked several genes to susceptibility to type 1 diabetes, but scientists are confident that more genes exi...Brain tumor study reveals why treatment efforts fail in genetic disorder
...s. Another form of RAS previously suspected to be linked to neurofibromatosis, called H-RAS, did not mimic loss of the Nf1 gene in tissue culture or in live animals. "Collectively, these results suggest that K-RAS activation, specifically, is the biological equivalent of Nf1 loss in astrocytes," Gutmann sa...A key signaling molecule in osteoarthritis is identified
... two types of collagens, type IX and XI, have been linked to early-onset osteoarthritis. However, the link b...f several drugs used to treat arthritic pain being linked to severe side effects.......ic use of laxatives and whether these drugs can be linked to nerve damage and risks of colorectal or other cancers. Data shows that those on the market today are safe when appropriate drugs are prescribed and taken at recommended doses. With this information, Dr. Mller-Lissner suggests that "patients may n...DNA movement linked to formation of antibody genes
...professor of entomology is part of a team that has linked the movement of small pieces of DNA, known as transposable elements, to a process called V(D)J recombination that produces the genetic diversity responsible for the production of antibodies. This will help scientists understand the mixing and matchin...Backcountry water quality tests are good news for campers
...tes, only 17 had levels high enough to be directly linked to recreational use or the presence of livestock. "For these two studies, we looked at nearly100 streams and lakes over the 400-mile long mountain range," observed Derlet, who has given presentations to wilderness rangers about infectious diseases...New method simplifies search for genetic changes associated with disease
...mparisons that highlight the changes most commonly linked to disease, providing them the leads they need to ...pplied direct genomic selection to a region of DNA linked to psoriasis, a disfiguring and potentially debilitating inherited skin condition. "We quickly found...Researchers tease out one critical role of tumor-suppressor gene
...evelops and progresses. While mutations in Rb, are linked to several types of cancer including the childhood...wing out of control. Scientists believe that Rb is linked to two key processes that frequently malfunction when cancer begins proliferation (cell growth), an...Scientists discover key genetic factor in determining HIV/AIDS risk
...riations in the CCR5 gene that they had previously linked to varying rates of AIDS progression. They found that individuals who possessed a low CCL3L1 copy number along with disease-accelerating CCR5 variants had an even higher risk of HIV acquisition and rate of progression to AIDS. "This work adds signifi...In Nature paper, scientists at U.Va. health system crack part of 'histone' code
... regulation of genes." Chd1 mutation has been linked to a rare neurological disease called CHARGE syndrome that causes birth defects, including eye abnormalities, facial palsy and swallowing problems, blocked nasal passages, heart defects and delayed development. Already, Grant and his colleagues are w...COX-2 levels are elevated in smokers
...iggers the production of COX-2, a cellular protein linked to the development and progression of cancer, according to research published in the January 15 issue of the journal Cancer Research . Tobacco smoke also promoted rapid cellular production of two proteins that initiate an epidermal growth factor re...Researchers find how protein allows insects to detect and respond to pheromones
...t control and repellents." Other studies have also linked OBPs to insect behavior. A 2002 fire ant study suggested a role for OBPs in worker ants' ability to recognize queens and regulate the number of queens in a colony. The new UT Southwestern findings represent "a major breakthrough in our understandin...Protein adiponectin appears protective against heart disease
...ture cardiac events." Adiponectin has been closely linked with insulin resistance, a known risk factor for heart disease. Adiponectin is one of the most abundant circulating proteins in human plasma, explained Dr. Orchard, who also is medical director of the nutrition lipid program at the University of Pitt...A new New Year's reason to work out: Exercise improves three measures of heart protection
... (blood clotting) system that have previously been linked to heart attacks. Lead author Linda Szymanski expl...ea for this study because "We all know exercise is linked with reduced heart attacks. Everyone says this is because exercise lowers your cholesterol, etc., b...Born to run? Capacity for aerobic exercise linked to risk of heart disease
...exercise capacity and high scores for risk factors linked to metabolic syndrome physical changes often seen...low aerobic capacity scored higher on risk factors linked to cardiovascular disease including high blood pressure and vascular dysfunction," says Ulrik Wislo......ed in parallel, rather than sequentially, and then linked together in many different combinations with the DNA strands. "So it's like having a shelf full of Tinker Toys," Baker said. An array of single-functional dendrimers, such as targets, drugs, and contrast agents, and the ability to link them togethe...