Inflammation may cause preterm labor and fetal deaths
...igators noted that inflammation closely paralleled localization of bacteria. In the present study, the researchers found that mice deficient in TLR4 lacked the necro-inflammatory response to bacteria and produced healthy pups. This discovery led Han and her colleagues to attempt to block the inflammatory proces...JCI table of contents: August 1, 2007
...w much is retained by the body. This inappropriate localization prevents EGF activating its receptor and thereby increasing the expression of a protein know as TRPM6 that enables the cells of the kidney to take up magnesium and prevent it from being lost in the urine. The importance of this process was highlighte...SNM initiatives supported by inclusions in NAS Report on competitiveness of US chemistry research
...tional and instrument development for more precise localization of radiotracers in normal and aberrant cell physiologies; national impediments to the efficient entry of promising new radiopharmaceutical compounds into clinical feasibility studies and strategies to overcome them and impacts of shortages of isotope...PET/CT use expands: Effectively diagnosing graft infections
...es that it provides accurate detection and precise localization of vascular graft-related infections," she said. "Blood vessels can be occluded (obstructed) due to disease processesoften as a complication of diabetesdecreasing blood flow to various regions of the body and occurring more commonly in the lower l...NASA-funded robotic sub finds bottom of world's deepest sinkhole
...holes interior via a technique called simultaneous localization and mapping, or SLAM. Prior to the DEPTHX field experiment, SLAM had been used for navigating in buildings and mines, but had never operated in an underwater environment or with such sparse sensor input. Robots typically navigate by recognizing feat...New research shows sharks use their noses and bodies to locate smells
...eral line, and vision in odor source detection and localization in the smooth dogfish shark. The results, which appear in the June 1 issue of the Journal of Experimental Biology, show that this shark is severely handicapped in its ability to locate the source of an odor when deprived of information from its later...Where is the proton? Yale scientists discover footprints of shared protons
...environment over a huge range and followed how the localization of the proton changed. We found that the way the proton is localized depends very much on the chemical properties of the atoms you are trapping it with."...'Fusion' protein found by Johns Hopkins researchers
...e the Solitary protein, enabling them to track its localization under a fluorescent microscope. At each future fusion point between cells that they examined in the fly muscles, they saw concentrations of glowing clumps of Solitary protein. "As we uncover more of the players in cell fusion, we get closer to m...NYU scientists identify how development of different species uses same genes with distinct features
...terior promoting function of bicoid while anterior localization of giant mRNA represses posterior development. "This comparison of the molecular mechanisms employed by two independently evolved species not only uncovers those features essential to this portion of development, but also shows that we are now in a...Protein structures for the entire yeast proteome
...with data on the biological process, function, and localization of the proteins from previous experimental studies to assign the domains to families of evolutionarily related proteins. These genome-wide domain predictions and superfamily assignments provide the basis for the generation of experimentally testable ...News tips from the Journal of Neuroscience
...a the SH3 domain of SAP97, was required for ADAM10 localization at postsynaptic membranes. Glutamate receptor activation increased SAP97-mediated membrane trafficking of ADAM10 and increased APP cleavage at the a-secretase site. Because the a-secretase activity attributed to ADAM10 occurs in the membrane compartm...Improved imaging for identifying breast cancer in overweight women
...added, "It also provides a more precise anatomical localization of the nodes prior to surgery, thus facilitating the surgical procedure." In this study, Israeli researchers calculated their subjects' body mass indexes and evaluated 220 women with invasive breast cancer by identifying sentinel nodes in three way...Linheng Li Lab documents the development of cancer stem cells
...es stem cell activation by helping control nuclear localization of beta-catenin, the Wnt pathway effector, through phosphorylation of beta-catenin -- including Serine552. "We found that a loss of PTEN in intestinal epithelial cells accompanied by a loss of PTEN in stromal cells can lead to changes that may in...Prenatal cocaine's lasting cellular effects
...e determined, he cautioned, is whether D1 receptor localization is affected in humans exposed to cocaine prenatally. If found in humans, "it gives us a new way to think about helping those children as they continue to mature." Because cocaine exposure seems to alter the distribution of the D1 receptor, Stanwoo...Reduced frontal-lobe activity and impulsivity may be linked to alcoholism risk
...hered through questionnaires. Furthermore, source localization of brain sources contributing to P3s was computed through a recently developed method of low-resolution electromagnetic tomography called LORETA. Results showed that the alcohol-dependent subjects, as well as those individuals with high impulsivity...News tips from the Journal of Neuroscience
... protein Staufen, which has been implicated in RNA localization and translational regulation. 3. Sleepless in the Aquarium David A. Prober, Jason Rihel, Anthony A. Onah, Rou-Jia Sung, and Alexander F. Schier You"d think fish would not have that much on their minds to keep them up at night. But this week, Pro...Sniffers show that humans can track scents, and that two nostrils are better than one
...ion, however, was whether two nostrils allow scent localization in the same way that a human's two ears and eyes help locate sounds and sights. To further test this, the researchers devised an ingenious nasal "prism" that mixed scents from the outside world and then presented this to both nostrils, so that ther...Nanoscale microscope sheds first light on gene repair
...d Bewersdorf. "Moving forward, we will analyze the localization of the H2AX clusters relative to other nuclear components."...Dartmouth study contributes to research addressing malnutrition and iron deficiency
...orage site. The researchers also learned that this localization is dependent on a protein called VIT1, shown to transport iron into the vacuole. Dartmouth Professor of Biological Sciences Mary Lou Guerinot, the principal investigator on the study, says, "Iron deficiency is the most common human nutritional dis......al storage site. The researchers also learned this localization depends on a protein called VIT1, known to transport iron into the vacuole. "Iron deficiency is the most common human nutritional disorder in the world today, afflicting more than 3 billion people worldwide," said Mary Lou Guerinot, a biologist at ...