Future diabetes drugs may target new protein interaction
... the pyruvate-sirtuin1 connection more closely and looking for more details of the sirtuin1-PGC1 interaction. Also on the to-do list: examining sirtuin1 and PGC1 in other tissues, particularly muscle and fat, two other energy-producing tissues in mammals. The study was funded by the Ellison Medical Foundatio...Fine-tuning calf nutrition could reduce nitrogen pollution
...ccelerated calf growth program is one way they are looking to increase efficiency and productivity," said Dr. Barry Lambert, who has a joint appointment with the Experiment Station and Tarleton State University. But current accelerated growth programs run the risk of not only overfeeding some nutrients, whi...'Grubby' research promises environmental/economic benefits
...a living." Tomberlin, a Texas A&M entomologist, is looking into the possibility that black soldier fly larvae "grubs" to the uninitiated could be used to turn livestock manure into high-protein feed. The concept itself has been proven practical for reducing poultry litter: The flies lay their eggs in the a...Researchers find three major beetle groups coming up one testis short
...rt in the field. We still have much to discover by looking at whole organisms." Other co-authors are David Maddison at the University of Arizona and Jos Galin at the Departamento de Biologa Animal Facultad de Veterinaria in Murcia, Spain....Hydrogen and methane provide raw energy for life at 'Lost City'
...ntists who named the spot Lost City knew they were looking at something never seen before when the field was ...vents that they may provide a whole new avenue for looking for the earliest life on Earth and for signs of life on other planets, according to Deborah Kelley, ...Stealth worms may improve insect pest control
... funded by the National Science Foundation. "We're looking at all groups of nematodes in tropical rainforests...e state have the parasitic citrus nematode. "We're looking for options in pest control," Stock says. "We're using the entomopathogenic nematodes to antagonize ...Dental researchers answer key enamel question
...be the scaffold for biomineralization she had been looking for. It was a leap that her scientific training told her was excessively optimistic. "I think what you need is a bit of imagination to be able to link these things," she said. When the researchers mineralized the ribbons and dipped them into calcium ...Cure no quick fix for cancer survivors on long road to recovery
...lso act as a barrier, or a subtle disincentive, to looking for ways to improve deficits in quality of life. Recognition of these deficits is the first step toward trying to improve things."...Consortium to create comprehensive tools for uncovering the functions of human, mouse genes
...and academia can work together." "Sigma Aldrich is looking forward to participating in the development of these reagents and the associated methods," said Dave Julien, president of biotechnology at Sigma-Aldrich. "The TRC is consistent with our goal of enabling progress in biomedical research." Separately, ...... all the genes in the genome," he said. That means looking at both normal subjects and patients with diseases. "Papers like this one define the starting gate," said Scherer. "Now the research community is taking the next step. We are in a unique position at BCM of being in the largest clinical concentration...High cholesterol levels accelerate growth of prostate cancer
... tumors were markedly larger in size. "What we're looking at is progression, not initiation of a tumor," says Freeman. In addition, test-tube studies showed that when the cholesterol-lowering drug simvastatin was used to reduce cholesterol in cell membranes, the Akt pathway was inhibited, apoptosis incr...Chemists identify key gene in development of type 1 diabetes
...etes," says Al-Abed. "We don't know yet, but we're looking into this." Besides drug intervention, the new finding could lead to gene therapy to prevent the disease, possibly by disrupting the network of genes involved in its development, he says. A potential drug treatment based on blocking the MIF protein i...NJIT Presidential Award winner takes stem cell research another step
...ey are also suffering from other disorders. We are looking at the current treatment for repairing bone defects, which is the use of allograft tissue, as well as newer treatments such as combining allograft with stem cells." One day soon, as a result of Arinzeh's research, patients could be treated with off-...Antibodies from plants protect against anthrax
...y, inexpensive and, very stable system. If you're looking for a way to stockpile a large amount of antibodies for a long periods of time, plant-produced antibodies are the answer," says Baillie. Anthrax antibodies are just the first step for Baillie and his collaborators. Plantibodies against the plague...First real-time view of developing neurons reveals surprises, say Stanford researchers
...f branches stabilized into the mature form. "We're looking at a dynamic process that nobody has ever seen before," Smith said. Understanding how neurons mature into their adult role goes beyond zebra fish and their ability to see their eventual planktonic prey. "Probably these same processes are happening in...Researchers call for expanding the repertoire in studying birdsong
...d," said Beecher. "Researchers would benefit from looking at species that do things differently because there are very different learning patterns. There is no one typical way in which songbirds learn." "Some birds stick with what they learned the year before, others change," added Brenowitz. "There is a ...Protein protects kidneys from damage caused by chronic renal disease and injury
...involved in embryonic kidney development. "We were looking for DNA sequences with cysteine-rich domains, because we knew they were important in BMP signal suppression," Dressler says. "But as we worked with KCP, we realized it's not a suppressor at all." In initial studies, Dressler and his research team fou...BRCA1 causes ovarian cancer through indirect, biochemical route
...? Dubeau eventually got a handle on the problem by looking at ovarian cancer rates in genetically modified mice created in collaboration with Robert Maxson, Keck School professor of biochemistry and molecular biology and director of the mouse core facility at the USC/Norris Cancer Center. "The whole project ...The transparent organism: EMBLEM and Carl Zeiss give labs a unique look at life
...and unwanted light which prevented scientists from looking deep into tissues in the past. The entire procedure is very fast and in a computer supported post-processing step, one or more stacks of images are assembled into a high-resolution film. Another advantage of SPIM is that the specimen is kept alive in......tent of lilies can be predicted reasonably well by looking at a related plant with a small genome, like rice, he said. To breed better crops, it's important to be able to leverage the information from the tractable model systems that scientists already know so much about. "We will continue to add new feature...