Scientists identify molecule that regulates well-known tumor suppressor
... PTEN suppressor. In studies with mammalian cells, low levels of DJ-1 correlated with decreased PKB/Akt activity, while increased DJ-1 led to activation of PKB/Akt and enhanced cell survival. In cancer cells from breast cancer patients, elevated PKB/Akt activity and reduced PTEN expression were associate...Nature helps create religious adults
...came more dissimilar. "These correlations suggest low genetic and high environmental influences when the twins were young but a larger genetic influence as the twins age" the authors state. Participants for this study were 169 MZ and 104 DZ male twin pairs from Minnesota. Religiousness was tested usi...Liposome finding implies electrical effect on cell development
...d liposomes in a droplet of water and applied very low electric fields (5-10 volts per centimeter), much lower than the fields present in operating neurons (a fraction of a volt but operating over a very short distance--less than a micron--to produce a field up to one thousand times stronger). In images...Robot-based system developed at Carnegie Mellon detects life in Chile's Atacama desert
... of other remote methods capable both of detecting low levels of micro-organisms and visualizing high levels incorporated as biofilms or colonies," said Gregory Fisher, project imaging scientist. "Our fluorescent imager is the first such system to work in the daylight while in the shade of the rover. The...Antioxidant blood levels key to MnSOD gene
...nversely, if carriers of this genetic variant have low levels of these vitamins and minerals, their risk ...r blood. Compared to MnSOD VV or VA carriers with low selenium those men in the lowest quartile of the study group MnSOD AA males had an 89 percent grea...Studies expand understanding of X chromosome
...alyzed to date. Researchers say this may reflect a low density of genes on the ancestral chromosome that ...se of mammalian evolution. Despite its relatively low gene density, the X chromosome holds a prominent place in the study and understanding of human disea...JCI table of contents April 1, 2005
...cribe a new mouse model that mimics the effects of low dose aspirin to explore how such therapy would imp...ill have significant value in studying the role of low dose aspirin in several pathological conditions, such as preeclampsia, thrombosis and inflammation. ...Birthing a new model of aspirin therapy in preeclampsia
...cribe a new mouse model that mimics the effects of low dose aspirin to explore how such therapy would imp...ill have significant value in studying the role of low dose aspirin in several pathological conditions, such as preeclampsia, thrombosis and inflammation. ...Chemists identify key gene in development of type 1 diabetes
... experimental diabetes induced in mice by multiple low doses of streptozotocin. Attenuation of MIF activity with neutralizing antibodies against MIF, or the pharmacological MIF inhibitor (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester (ISO-1), markedly reduces histopathological...Tips from the Journals of the American Society for Microbiology
... for treatment. The have the advantages of safety, low cost of production, and ease of use in field conditions due to their minimal need for refrigeration. In the study the DNA of a simian/human immunodeficiency virus (SHIV) was made noninfectious by removing the gene that makes reverse transciptase (a ...Study supports use of aspirin in treating pregnancy disorder
... significant value in studying the implications of low dose aspirin in several pathological conditions, such as pre-eclampsia, thrombosis, and inflammatory disorders," says Dr. Funk. "We're hopeful that our model will lead the way to further treatment options for these debilitating conditions."...Breath may help diagnose infection
...rently healthy populations could be expected to be low or undetectable," says Boggs. Now that they have shown the concept of exhaled breath diagnostics to be viable, the next step is to move into human testing. Having determined in earlier studies that the early responses of cells to infection vary bas...Food preservative neutralizes anthrax spores
...ptide used as a preservative in heat-processed and low pH foods. It is derived from the controlled fermentation of the naturally occurring milk bacteria Lactococcus lactis. Nisin was awarded the Generally Regarded as Safe (GRAS) designation in the U.S. Federal Register of April, 1988 and is approved as ...Monsanto fund awards $3.7 million to Washington University for school science van program
...epresented public schools, and districts that have low average scores on the third grade science Missouri Achievement Program (MAP) test. Deborah Patterson, president of the Monsanto Fund, explained the idea behind the project. "We wanted to bring a new level of excitement to science education by creat...Fish oil holds promise in Alzheimer's fight
...vent or treat Alzheimer's disease after noting the low prevalence of dementia among the elderly in India, where curry is a staple....Researchers trace evolution to relatively simple genetic changes
...also shows that the same gene is used whenever the low armor trait evolves. "We used sequencing studies t...cean fish with complete armor, and we found a very low level of this genetic variant in the marine population." So, he said, "the marine fish actually car...Fewer fish discarded after individual transferable quotas offered
...ean U.S. fisheries may never have discard rates as low as those of British Columbia, the authors say. Such a change also would involve the cost of 100 percent observer coverage, although the authors write the costs may be outweighed by the benefits. "In many ITQ [individual transferable quotas] fisherie...Yeast finding links processes in heart disease and cancer
...red a number of years ago how human cells react to low oxygen levels, but that process has never been con...s not enough oxygen around to make it. And because low cholesterol levels automatically turn on the yeast's version of SREBP, it's an easy solution to have...Highly adaptable genome in gut bacterium key to intestinal health
... were fed a diet high in complex carbohydrates and low in simple sugars. Ten days later, the activity of all genes in the bacterial genome was surveyed in B. theta from the mice's guts. The research team found that 1,237 of the bacterium's 4,779 genes were highly active compared to B. theta grown in a s......maging agents can be toxic, and doses that are too low allow for DNA repair and further cell growth. Thus, says Dr. Thomas, there is need for drugs that can sensitize cells to lower doses of DNA-damaging agents to guarantee cell death, but without the toxic side effects. The researchers studied the resul...