JCI table of contents November 1, 2004
...rs found that approximately 10% of individual with low HDL levels in the general population have a mutati...rchers showed that the 4 out of 9 individuals with low HDL specifically carry 1 of the 2 mutations identified in families with Tangier disease. These data ...Mutations in transporter protein effect HDL levels in the general population
...rs found that approximately 10% of individual with low HDL levels in the general population have a mutati...rchers showed that the 4 out of 9 individuals with low HDL specifically carry 1 of the 2 mutations identified in families with Tangier disease. These data ...First human trial of bioartificial kidney shows promise for acute renal failure
...rlier because of reactions such as hypoglycemia or low platelet counts, or because of complications related to their other medical conditions. The bioartificial kidney includes a cartridge that filters the blood as in traditional kidney dialysis. That cartridge is connected to a renal tubule assist devic...Scientists raise concerns about second wave of 'mad cow' prion infection
..."This may not be a disease in decline, despite the low number of cases today," said Dr. Eglin. "There is much uncertainty over the number of cases predicted for the UK. Estimates of up to 25,000 total cases have been predicted with an incidence of one in 24,000 of the UK population." The second case of ...Researchers discover transport molecule that allows boron into cells
... function," said Dr. Muallem. For animals kept on low boron diets, the effect of boron deficiency is clear. Numerous birth defects occur, including impaired growth and missing or extra limbs. Many animals cannot survive in the complete absence of boron. On the other hand, like many vitamins and mineral...Scientists find acid rain an unlikely ally in the battle against a greenhouse gas
... Britain and Sweden they attempted to determine if low levels of sulfate, like those in acid rain, affect...ts, acquired over several years, showed that these low doses of sulfate suppressed methane emissions between 30-40 percent. Matthews and climate experts ...... connectivity. Corridors were more effective in a low resistance matrix (one that facilitates high rates...) than a high-resistance matrix (one that promotes low rates of dispersal among patches), while stepping stones only increased planthopper colonization whe...High-predator environment has unexpected impact on aging in fish
...out predators and hence experienced either high or low mortality rates. The researchers evaluated aging i...-predation environments are faster than those from low predation environments. All guppies slowed down with age, but the rate of decline for fish in high-p...Scientists uncover secret to sharp teeth
...esearchers found that follistatin was expressed at low levels in active ameloblasts and at much higher levels in the dental epithelial cells lining the enamel-free surface of the incisors. Mice engineered to lack follistatin had functional ameloblasts on the normally enamel-free surface adjacent to the ...International marine survey of coral death
...pillover of antibiotics from fish pens can lead to low doses of antibiotic being delivered to the wider marine ecosystem, with resulting selection for antibiotic resistance" among disease pathogens, the researchers wrote. Rather, the marine scientists suggest in the Frontiers article, prevention migh...Asymmetric organs and microRNA-directed DNA modification
...al, high levels of methylation are associated with low levels of transcription while low levels of methylation are associated with high transcription rates. "To test whether the microRNA co...Young adults who maintain their weight have lower risk factor levels for heart disease
...icate risk for diabetes, high triglyceride levels, low levels of good cholesterol, and a large waist. Metabolic syndrome is defined as having at least 3 of these risk factors. Investigators found that on average as body mass index, an indicator of obesity, increased, adverse changes in these cardiovascu...Sea change: Skeletons of ancient corals different from today's
...years ago? The possible answer: Ancient seawater's low magnesium-to-calcium ratio during this interval ma...ed making reefs during the Cretaceous: because the low magnesium/calcium ratios in the oceans at that time inhibited the growth of the aragonite mineral th...Grants target better predictors for type 1 diabetes
...going to be diabetic will be high for one protein, low for another and maybe moderate for the third. Maybe someone who is not going to develop diabetes will have a different combination. So if you were to plot that in three-dimensional space, you can look at different spheres, with diabetes in one spot a...New study links low fish supply to increased bushmeat hunting
...les and oil prices. They also found that low fish counts were linked to higher hunter counts by...t fish prices were high when fish availability was low indicates that the link with high bushmeat sales was driven by low fish supply," said Andrew Balmfor...New studies regarding the efficacy of antioxidants and their impact on standard cancer treatment
...nts taken during treatment and multi-vitamins with low dosages of antioxidants after the completion of therapy (Kedar N. Prasad). Investigation of a potential radioprotective agent with little or no toxicity that was developed from the fruit of Aegle marmelos (AME) (Ganesh Chandra Jagetia, Ponemone Ven...New findings may redirect strategies for treatment of prostate cancer
...les downstream of the AR are active even with very low levels of androgen. A considerable amount of effort has gone into dissecting the signaling pathways that regulate the AR to look for pharmacological tools that can attenuate abnormal AR function. Dr. Charles L. Sawyers and colleagues from the David ...UCSD discovery opens new avenues for design of anti-tumor medications
The response of blood vessels to low oxygen levels may be the Achilles' heel of a devel... first to examine how blood vessels respond to the low oxygen conditions that result from the presence of a growing tumor. Previous work by the UCSD group...Army-funded effort examines androgen's role in bone loss
...row surface inside the bone, reduced bone loss and low bone "turnover." Biomechanical analysis showed that the bones were not stronger, however, with reduced load capability and different material properties. The study also demonstrated that androgen receptors are important to the development...Study in Royal Society journal on evidence for impact of global warming on bird populations
...revious years. Productivity in 2003 was relatively low for already declining species while it was relatively good for increasing species. This adds evidences that climate warming plays a key role in the long term dynamics of even the commonest species. This further suggests that ability to reproduce in w...