After flu exposure, mild exercise protects mature mice from dying
...echanisms. Areas that they'll be studying include: lung histopathology, cytokine gene and protein expression in the lung, and possible development of flu-specific immune cells. At the moment, the laboratory also has a large NIH-funded human clinical trial underway examining whether or not moderate exercis...Cooperation to create a new tuberculosis vaccine
...hs. The objective is to prevent the disease in the lung (pulmonary TB). To prevent the outbreak of TB after an infection, a complex cellular immune response against the pathogen has to be stimulated. In other fields, MOLOGEN has already demonstrated that its DNA vaccines stimulate the cellular immune resp...New method identifies chromosome changes in malignant cells
...nvolved in a host of diseases, including lymphoma, lung cancer and gastric cancer." Troyanskaya and colleagues are continuing their work on chromosome additions and deletions by collaborating with cancer researchers to refine their search for alterations that are involved in tumor growth....Environmental exposures before and after birth can harm children's lungs
...ndings may suggest that the harmful effects on the lung develop after prolonged or later exposure to ETS. "At this point we can only speculate how PAH exposure, in conjunction with ETS, causes respiratory damage," said Dr. Miller. "One possibility is that PAHs, which easily reach the fetus and damag...S1P1 essential for tumor growth and is blocked by RNA interference
...s in tumors. The authors implanted mice with Lewis lung carcinoma cells and examined tissue sections for S1P1 expression. S1P1 expression was found in the blood vessels only in the areas around the implanted tumor. The researchers then developed an RNA interference technique, a method that specifically bl...Other highlights in the October 20 JNCI
...inding protein 3 (IGFBP-3)--a natural inhibitor of lung cancer cell survival and growth--is frequently decreased in lung cancers, a trait associated with poor prognosis and survival. A potential obstacle to treating lung ...Lag-3 gene dampens immune responses by controlling regulatory T-cell function
... T cells that ordinarily would have caused a fatal lung disease. Next, the team used a technique called DNA array analysis to identify which genes in the CD4+ T cells are activated in cells that develop into regulatory T cells. The investigators found that the Lag-3 gene was "expressed" (being us...Genetics play role in response to most common asthma drug
...more symptoms, lower FEV1 scores (a measurement of lung function) and more frequent use of quick-relief medication. Overall, participants with the arginine genotype had improved asthma control when not using albuterol. In contrast, participants with the glycine genotype had better asthma control with alb...A clear view of mycobacterial infection
...m and the host has been that it occurs deep in the lung of the infected animal. To overcome this limitation, Ramakrishnan and colleagues used zebrafish embryos, which are transparent and can be infected by a relative of the TB pathogen, M. marinum. This enables the researchers to watch cells as they are r...Red wine mist? Resveratrol shows potential effects against COPD, asthma, arthritis
...icle, "Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms," appears in the October issue of American Journal of Physiology-Lung Cellular and Molecular Physiology, published by the American Physiological Society. In addition to Donnelly, other members of the research t...Gene found to defend against environmental pollutants and pulmonary emphysema
... what factors make some people more susceptible to lung diseases. The article is published in the current ... important thing to remember is that the degree of lung damage depends on the ability to defend against environmental factors. We now know that Nrf2 is the ...Gene that blocks free radical damage protects against emphysema
...ma is a major manifestation of chronic obstructive lung disease, which affects more than 16 million Americ...recently been alleged to play an important role in lung susceptibility to cigarette smoke-induced damage. To investigate the impact of oxidative stress on e...JCI table of contents November 1, 2004
...ma is a major manifestation of chronic obstructive lung disease, which affects more than 16 million Americ...recently been alleged to play an important role in lung susceptibility to cigarette smoke-induced damage. To investigate the impact of oxidative stress on e...Other highlights in the November 3 JNCI
..., relapsed or refractory non-Hodgkin lymphoma, and lung cancer. Response to the drug varies in different people because of variations in the enzymes that metabolize the drug, including cytochrome P450 3A4 (CYP3A4) and uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1). Alex Sparreboom, Ph.D., of the...Cell enzyme may help suppress cancer development
... for producing PTPRO is silenced, as can happen in lung cancer, for example, the amount of the enzyme drop...the PTPRO gene for methylation in 43 primary human lung tumors and their matching normal adjacent tissue. Fifty-one percent of the tumor samples were heavil...Link between immune protein and longer survival in melanoma patients identified
...of Health Evaluation Sciences at U.Va. "With lung disease for example, where surgery may not be an option, vaccines offer a treatment alternative to prolong the lives of patients," David Mullins said. "Something as simple as the induction of a particular chemokine receptor on T cells can translate i...New tool highlights activity of key cellular signal
... conditions such as asthma, allergy, inflammation, lung disease and heart disease. The tool -- a special f...cation in inflammation, allergy, asthma or chronic lung disease, conditions that may be helped by increasing cyclic AMP. More recently, altered regulation o...Community living causes bacteria to diversify
...y chronic human infections such as cystic fibrosis lung infections, heart valve infections, and wound infections in people with diabetes. In biofilms, organisms live clustered together, encased in a self-produced slime. "Biofilm infections are a major medical problem, and one focus of our lab is to unders...New protein identified in development of lung cancer
...truction may be a key player in the development of lung cancer. Writing in the Nov. 17 issue of the Journ... by evaluating Pirh2 expression in human and mouse lung tumor samples and comparing it with Pirh2 expression in normal tissue from the same samples. They fo......for degradation. In a new study of human and mouse lung tumors, Miguel A. Villalona-Calero, M.D., of Ohio ...Pirh2 protein expression was higher in most of the lung tumors compared with normal lung tissue. In addition, in the mouse tumors, p53 was more ubiquinated-...